Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system

Detalhes bibliográficos
Autor(a) principal: Passos,Marieta L. C.
Data de Publicação: 2008
Outros Autores: Saraiva,M. Lúcia M. F. S., Lima,José L. F. C., Korn,M. Graças A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000300027
Resumo: A mechanized system for the determination of beta-blockers in pharmaceutical formulations is presented. Using the Sequential Injection Analysis (SIA) technique it was achieved a simple, economical and versatile methodology adaptable to any pharmaceutical control involving these substances. It does not require any pre-treatment for the samples, as they must only be dissolved in acid before analysis. Linear calibration plots were obtained for metoprolol (40.52 - 250 mg L-1), acebutolol (32.85 - 140 mg L-1) and propranolol (16.58 - 120 mg L-1). A R.S.D. lower than 5% was attained. The methodology was used in tablets, injections and prolonged-release capsules. Common excipients used in pharmaceuticals do not interfere. Statistical comparison of the results obtained with the proposed methodology and with the official methods showed good agreement (95% confidence level). SIA system produces only 2.50 mL of effluents per determination whereas the reference methodologies consume around 140 mL.
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spelling Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA systembeta-blockerssequential injection analysisSIAspectrophotometrypharmaceutical formulationsA mechanized system for the determination of beta-blockers in pharmaceutical formulations is presented. Using the Sequential Injection Analysis (SIA) technique it was achieved a simple, economical and versatile methodology adaptable to any pharmaceutical control involving these substances. It does not require any pre-treatment for the samples, as they must only be dissolved in acid before analysis. Linear calibration plots were obtained for metoprolol (40.52 - 250 mg L-1), acebutolol (32.85 - 140 mg L-1) and propranolol (16.58 - 120 mg L-1). A R.S.D. lower than 5% was attained. The methodology was used in tablets, injections and prolonged-release capsules. Common excipients used in pharmaceuticals do not interfere. Statistical comparison of the results obtained with the proposed methodology and with the official methods showed good agreement (95% confidence level). SIA system produces only 2.50 mL of effluents per determination whereas the reference methodologies consume around 140 mL.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000300027Journal of the Brazilian Chemical Society v.19 n.3 2008reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532008000300027info:eu-repo/semantics/openAccessPassos,Marieta L. C.Saraiva,M. Lúcia M. F. S.Lima,José L. F. C.Korn,M. Graças A.eng2008-05-27T00:00:00Zoai:scielo:S0103-50532008000300027Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2008-05-27T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
title Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
spellingShingle Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
Passos,Marieta L. C.
beta-blockers
sequential injection analysis
SIA
spectrophotometry
pharmaceutical formulations
title_short Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
title_full Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
title_fullStr Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
title_full_unstemmed Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
title_sort Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
author Passos,Marieta L. C.
author_facet Passos,Marieta L. C.
Saraiva,M. Lúcia M. F. S.
Lima,José L. F. C.
Korn,M. Graças A.
author_role author
author2 Saraiva,M. Lúcia M. F. S.
Lima,José L. F. C.
Korn,M. Graças A.
author2_role author
author
author
dc.contributor.author.fl_str_mv Passos,Marieta L. C.
Saraiva,M. Lúcia M. F. S.
Lima,José L. F. C.
Korn,M. Graças A.
dc.subject.por.fl_str_mv beta-blockers
sequential injection analysis
SIA
spectrophotometry
pharmaceutical formulations
topic beta-blockers
sequential injection analysis
SIA
spectrophotometry
pharmaceutical formulations
description A mechanized system for the determination of beta-blockers in pharmaceutical formulations is presented. Using the Sequential Injection Analysis (SIA) technique it was achieved a simple, economical and versatile methodology adaptable to any pharmaceutical control involving these substances. It does not require any pre-treatment for the samples, as they must only be dissolved in acid before analysis. Linear calibration plots were obtained for metoprolol (40.52 - 250 mg L-1), acebutolol (32.85 - 140 mg L-1) and propranolol (16.58 - 120 mg L-1). A R.S.D. lower than 5% was attained. The methodology was used in tablets, injections and prolonged-release capsules. Common excipients used in pharmaceuticals do not interfere. Statistical comparison of the results obtained with the proposed methodology and with the official methods showed good agreement (95% confidence level). SIA system produces only 2.50 mL of effluents per determination whereas the reference methodologies consume around 140 mL.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000300027
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000300027
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532008000300027
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.19 n.3 2008
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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