Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000300027 |
Resumo: | A mechanized system for the determination of beta-blockers in pharmaceutical formulations is presented. Using the Sequential Injection Analysis (SIA) technique it was achieved a simple, economical and versatile methodology adaptable to any pharmaceutical control involving these substances. It does not require any pre-treatment for the samples, as they must only be dissolved in acid before analysis. Linear calibration plots were obtained for metoprolol (40.52 - 250 mg L-1), acebutolol (32.85 - 140 mg L-1) and propranolol (16.58 - 120 mg L-1). A R.S.D. lower than 5% was attained. The methodology was used in tablets, injections and prolonged-release capsules. Common excipients used in pharmaceuticals do not interfere. Statistical comparison of the results obtained with the proposed methodology and with the official methods showed good agreement (95% confidence level). SIA system produces only 2.50 mL of effluents per determination whereas the reference methodologies consume around 140 mL. |
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Journal of the Brazilian Chemical Society (Online) |
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Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA systembeta-blockerssequential injection analysisSIAspectrophotometrypharmaceutical formulationsA mechanized system for the determination of beta-blockers in pharmaceutical formulations is presented. Using the Sequential Injection Analysis (SIA) technique it was achieved a simple, economical and versatile methodology adaptable to any pharmaceutical control involving these substances. It does not require any pre-treatment for the samples, as they must only be dissolved in acid before analysis. Linear calibration plots were obtained for metoprolol (40.52 - 250 mg L-1), acebutolol (32.85 - 140 mg L-1) and propranolol (16.58 - 120 mg L-1). A R.S.D. lower than 5% was attained. The methodology was used in tablets, injections and prolonged-release capsules. Common excipients used in pharmaceuticals do not interfere. Statistical comparison of the results obtained with the proposed methodology and with the official methods showed good agreement (95% confidence level). SIA system produces only 2.50 mL of effluents per determination whereas the reference methodologies consume around 140 mL.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000300027Journal of the Brazilian Chemical Society v.19 n.3 2008reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532008000300027info:eu-repo/semantics/openAccessPassos,Marieta L. C.Saraiva,M. Lúcia M. F. S.Lima,José L. F. C.Korn,M. Graças A.eng2008-05-27T00:00:00Zoai:scielo:S0103-50532008000300027Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2008-05-27T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system |
title |
Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system |
spellingShingle |
Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system Passos,Marieta L. C. beta-blockers sequential injection analysis SIA spectrophotometry pharmaceutical formulations |
title_short |
Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system |
title_full |
Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system |
title_fullStr |
Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system |
title_full_unstemmed |
Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system |
title_sort |
Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system |
author |
Passos,Marieta L. C. |
author_facet |
Passos,Marieta L. C. Saraiva,M. Lúcia M. F. S. Lima,José L. F. C. Korn,M. Graças A. |
author_role |
author |
author2 |
Saraiva,M. Lúcia M. F. S. Lima,José L. F. C. Korn,M. Graças A. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Passos,Marieta L. C. Saraiva,M. Lúcia M. F. S. Lima,José L. F. C. Korn,M. Graças A. |
dc.subject.por.fl_str_mv |
beta-blockers sequential injection analysis SIA spectrophotometry pharmaceutical formulations |
topic |
beta-blockers sequential injection analysis SIA spectrophotometry pharmaceutical formulations |
description |
A mechanized system for the determination of beta-blockers in pharmaceutical formulations is presented. Using the Sequential Injection Analysis (SIA) technique it was achieved a simple, economical and versatile methodology adaptable to any pharmaceutical control involving these substances. It does not require any pre-treatment for the samples, as they must only be dissolved in acid before analysis. Linear calibration plots were obtained for metoprolol (40.52 - 250 mg L-1), acebutolol (32.85 - 140 mg L-1) and propranolol (16.58 - 120 mg L-1). A R.S.D. lower than 5% was attained. The methodology was used in tablets, injections and prolonged-release capsules. Common excipients used in pharmaceuticals do not interfere. Statistical comparison of the results obtained with the proposed methodology and with the official methods showed good agreement (95% confidence level). SIA system produces only 2.50 mL of effluents per determination whereas the reference methodologies consume around 140 mL. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000300027 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000300027 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532008000300027 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.19 n.3 2008 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318168933400576 |