Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system

Detalhes bibliográficos
Autor(a) principal: Passos, Marieta L. C.
Data de Publicação: 2008
Outros Autores: Saraiva, Maria Lúcia M. F. S., Lima, José Luis Fontes da Costa, Korn, Maria das Graças Andrade
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/4970
Resumo: p. 563-568.
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spelling Passos, Marieta L. C.Saraiva, Maria Lúcia M. F. S.Lima, José Luis Fontes da CostaKorn, Maria das Graças AndradePassos, Marieta L. C.Saraiva, Maria Lúcia M. F. S.Lima, José Luis Fontes da CostaKorn, Maria das Graças Andrade2011-12-21T17:38:58Z2011-12-21T17:38:58Z20080103-5053http://www.repositorio.ufba.br/ri/handle/ri/4970v. 19, n. 3.p. 563-568.Apresenta-se um sistema mecanizado para a determinação de b–bloqueadores em preparações farmacêuticas. Através da utilização da técnica de Análise de Injeção Sequencial (SIA) foi obtida uma metodologia simples, econômica e versátil, adaptável a todo o tipo de controlo farmacêutico envolvendo estas substâncias. As amostras não necessitam de pré-tratamento devendo apenas ser dissolvidas em ácido antes de serem analisadas. Foram obtidas faixas lineares de trabalho para o metoprolol (40,52 - 250 mg L-1), acebutolol (32,85 - 140 mg L-1) e propranolol (16,58 - 120 mg L-1). O desvio padrão relativo foi inferior a 5 % em todas as determinações. A metodologia foi aplicada em comprimidos, injectáveis e cápsulas de libertação prolongada. Os excipientes que, usualmente, são empregues nas preparações farmacêuticas, não interferem. Os resultados obtidos usando a metodologia proposta foram estatisticamente comparáveis com os obtidos pelos métodos de referência (nível de confiança de 95%). O sistema SIA produz apenas 2,5 mL de efluentes por determinação enquanto que os métodos de referência originam 140 mL.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2011-12-21T17:38:58Z No. of bitstreams: 1 a27v19n3.pdf: 143734 bytes, checksum: bc1a54290a605f0849dd7bec6f758c28 (MD5)Made available in DSpace on 2011-12-21T17:38:58Z (GMT). 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dc.title.pt_BR.fl_str_mv Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
dc.title.alternative.pt_BR.fl_str_mv Journal of the Brazilian Chemical Society
title Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
spellingShingle Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
Passos, Marieta L. C.
Beta-blockers
Sequential injection analysis
SIA
Spectrophotometry
Pharmaceutical formulations
title_short Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
title_full Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
title_fullStr Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
title_full_unstemmed Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
title_sort Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system
author Passos, Marieta L. C.
author_facet Passos, Marieta L. C.
Saraiva, Maria Lúcia M. F. S.
Lima, José Luis Fontes da Costa
Korn, Maria das Graças Andrade
author_role author
author2 Saraiva, Maria Lúcia M. F. S.
Lima, José Luis Fontes da Costa
Korn, Maria das Graças Andrade
author2_role author
author
author
dc.contributor.author.fl_str_mv Passos, Marieta L. C.
Saraiva, Maria Lúcia M. F. S.
Lima, José Luis Fontes da Costa
Korn, Maria das Graças Andrade
Passos, Marieta L. C.
Saraiva, Maria Lúcia M. F. S.
Lima, José Luis Fontes da Costa
Korn, Maria das Graças Andrade
dc.subject.por.fl_str_mv Beta-blockers
Sequential injection analysis
SIA
Spectrophotometry
Pharmaceutical formulations
topic Beta-blockers
Sequential injection analysis
SIA
Spectrophotometry
Pharmaceutical formulations
description p. 563-568.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2011-12-21T17:38:58Z
dc.date.available.fl_str_mv 2011-12-21T17:38:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/4970
dc.identifier.issn.none.fl_str_mv 0103-5053
dc.identifier.number.pt_BR.fl_str_mv v. 19, n. 3.
identifier_str_mv 0103-5053
v. 19, n. 3.
url http://www.repositorio.ufba.br/ri/handle/ri/4970
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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