A Sensitive Voltammetric Determination of Anti-Parkinson Drug Pramipexole Using Titanium Dioxide Nanoparticles Modified Carbon Paste Electrode

Detalhes bibliográficos
Autor(a) principal: Hassaninejad-Darzi,Seyed Karim
Data de Publicação: 2017
Outros Autores: Shajie,Farshad
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000400529
Resumo: In this study, a facile sensor based on TiO2 nanoparticles modified carbon paste electrode was developed for voltammetric determination of pramipexole in pharmaceutical formulations and biological samples. Surface of the fabricated electrode have been characterized using field emission scanning electron microscopy. Under the optimized experimental conditions, the modified electrode was exhibited excellent electrocatalytic activities and a sensitive oxidation peak at 0.9 V in the phosphate solution of pH 5.0 for electrooxidation of pramipexole. The plot of pH vs. Ep generated a slope of 62.5 mV per pH in the pH range of 3.0-13.0 indicating the contribution of an equal number of electrons and protons in the electrode process. A differential pulse voltammetry method was developed in the concentration range of 0.46-100 μmol L-1 with a limit of detection of 0.14 μmol L-1. The proposed method is simple, rapid, and inexpensive and also showed good selectivity and sensitivity toward pramipexole.
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spelling A Sensitive Voltammetric Determination of Anti-Parkinson Drug Pramipexole Using Titanium Dioxide Nanoparticles Modified Carbon Paste ElectrodepramipexoleTiO2 nanoparticlesmodified CPEdifferential pulse voltammetryelectroanalysisIn this study, a facile sensor based on TiO2 nanoparticles modified carbon paste electrode was developed for voltammetric determination of pramipexole in pharmaceutical formulations and biological samples. Surface of the fabricated electrode have been characterized using field emission scanning electron microscopy. Under the optimized experimental conditions, the modified electrode was exhibited excellent electrocatalytic activities and a sensitive oxidation peak at 0.9 V in the phosphate solution of pH 5.0 for electrooxidation of pramipexole. The plot of pH vs. Ep generated a slope of 62.5 mV per pH in the pH range of 3.0-13.0 indicating the contribution of an equal number of electrons and protons in the electrode process. A differential pulse voltammetry method was developed in the concentration range of 0.46-100 μmol L-1 with a limit of detection of 0.14 μmol L-1. The proposed method is simple, rapid, and inexpensive and also showed good selectivity and sensitivity toward pramipexole.Sociedade Brasileira de Química2017-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000400529Journal of the Brazilian Chemical Society v.28 n.4 2017reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20160192info:eu-repo/semantics/openAccessHassaninejad-Darzi,Seyed KarimShajie,Farshadeng2017-03-06T00:00:00Zoai:scielo:S0103-50532017000400529Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2017-03-06T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv A Sensitive Voltammetric Determination of Anti-Parkinson Drug Pramipexole Using Titanium Dioxide Nanoparticles Modified Carbon Paste Electrode
title A Sensitive Voltammetric Determination of Anti-Parkinson Drug Pramipexole Using Titanium Dioxide Nanoparticles Modified Carbon Paste Electrode
spellingShingle A Sensitive Voltammetric Determination of Anti-Parkinson Drug Pramipexole Using Titanium Dioxide Nanoparticles Modified Carbon Paste Electrode
Hassaninejad-Darzi,Seyed Karim
pramipexole
TiO2 nanoparticles
modified CPE
differential pulse voltammetry
electroanalysis
title_short A Sensitive Voltammetric Determination of Anti-Parkinson Drug Pramipexole Using Titanium Dioxide Nanoparticles Modified Carbon Paste Electrode
title_full A Sensitive Voltammetric Determination of Anti-Parkinson Drug Pramipexole Using Titanium Dioxide Nanoparticles Modified Carbon Paste Electrode
title_fullStr A Sensitive Voltammetric Determination of Anti-Parkinson Drug Pramipexole Using Titanium Dioxide Nanoparticles Modified Carbon Paste Electrode
title_full_unstemmed A Sensitive Voltammetric Determination of Anti-Parkinson Drug Pramipexole Using Titanium Dioxide Nanoparticles Modified Carbon Paste Electrode
title_sort A Sensitive Voltammetric Determination of Anti-Parkinson Drug Pramipexole Using Titanium Dioxide Nanoparticles Modified Carbon Paste Electrode
author Hassaninejad-Darzi,Seyed Karim
author_facet Hassaninejad-Darzi,Seyed Karim
Shajie,Farshad
author_role author
author2 Shajie,Farshad
author2_role author
dc.contributor.author.fl_str_mv Hassaninejad-Darzi,Seyed Karim
Shajie,Farshad
dc.subject.por.fl_str_mv pramipexole
TiO2 nanoparticles
modified CPE
differential pulse voltammetry
electroanalysis
topic pramipexole
TiO2 nanoparticles
modified CPE
differential pulse voltammetry
electroanalysis
description In this study, a facile sensor based on TiO2 nanoparticles modified carbon paste electrode was developed for voltammetric determination of pramipexole in pharmaceutical formulations and biological samples. Surface of the fabricated electrode have been characterized using field emission scanning electron microscopy. Under the optimized experimental conditions, the modified electrode was exhibited excellent electrocatalytic activities and a sensitive oxidation peak at 0.9 V in the phosphate solution of pH 5.0 for electrooxidation of pramipexole. The plot of pH vs. Ep generated a slope of 62.5 mV per pH in the pH range of 3.0-13.0 indicating the contribution of an equal number of electrons and protons in the electrode process. A differential pulse voltammetry method was developed in the concentration range of 0.46-100 μmol L-1 with a limit of detection of 0.14 μmol L-1. The proposed method is simple, rapid, and inexpensive and also showed good selectivity and sensitivity toward pramipexole.
publishDate 2017
dc.date.none.fl_str_mv 2017-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000400529
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000400529
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20160192
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.28 n.4 2017
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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