Candida tropicalis CE017: a new Brazilian enzymatic source for the bioreduction of aromatic prochiral ketones

Detalhes bibliográficos
Autor(a) principal: Vieira,Gizelle A. B.
Data de Publicação: 2010
Outros Autores: Araujo,Daniel M. de Freitas, Lemos,Telma L. G., Mattos,Marcos Carlos de, Oliveira,Maria da Conceição F. de, Melo,Vânia M. M., Gonzalo,Gonzalo de, Gotor-Fernández,Vicente, Gotor,Vicente
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000800015
Resumo: The reactivity and stereoselectivity showed by a new strain of Candida tropicalis in the reduction of prochiral ketones have been compared with the ones previously attained in our laboratory using microorganisms from the Brazilian biodiversity. In this manner, Candida tropicalis has demonstrated its versatility as stereoselective agent in the bioreduction of a series of aromatic ketones. These prochiral compounds were converted into their corresponding optically alcohols with moderate to excellent stereopreference depending on the substrate structure. Among ketones tested, nitroacetophenones were enzymatically reduced to enantiopure (S)-alcohol with complete conversion.
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spelling Candida tropicalis CE017: a new Brazilian enzymatic source for the bioreduction of aromatic prochiral ketonesalcohol dehydrogenasesbiocatalysisCandida tropicalisketonesyeastThe reactivity and stereoselectivity showed by a new strain of Candida tropicalis in the reduction of prochiral ketones have been compared with the ones previously attained in our laboratory using microorganisms from the Brazilian biodiversity. In this manner, Candida tropicalis has demonstrated its versatility as stereoselective agent in the bioreduction of a series of aromatic ketones. These prochiral compounds were converted into their corresponding optically alcohols with moderate to excellent stereopreference depending on the substrate structure. Among ketones tested, nitroacetophenones were enzymatically reduced to enantiopure (S)-alcohol with complete conversion.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000800015Journal of the Brazilian Chemical Society v.21 n.8 2010reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532010000800015info:eu-repo/semantics/openAccessVieira,Gizelle A. B.Araujo,Daniel M. de FreitasLemos,Telma L. G.Mattos,Marcos Carlos deOliveira,Maria da Conceição F. deMelo,Vânia M. M.Gonzalo,Gonzalo deGotor-Fernández,VicenteGotor,Vicenteeng2011-10-14T00:00:00Zoai:scielo:S0103-50532010000800015Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2011-10-14T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Candida tropicalis CE017: a new Brazilian enzymatic source for the bioreduction of aromatic prochiral ketones
title Candida tropicalis CE017: a new Brazilian enzymatic source for the bioreduction of aromatic prochiral ketones
spellingShingle Candida tropicalis CE017: a new Brazilian enzymatic source for the bioreduction of aromatic prochiral ketones
Vieira,Gizelle A. B.
alcohol dehydrogenases
biocatalysis
Candida tropicalis
ketones
yeast
title_short Candida tropicalis CE017: a new Brazilian enzymatic source for the bioreduction of aromatic prochiral ketones
title_full Candida tropicalis CE017: a new Brazilian enzymatic source for the bioreduction of aromatic prochiral ketones
title_fullStr Candida tropicalis CE017: a new Brazilian enzymatic source for the bioreduction of aromatic prochiral ketones
title_full_unstemmed Candida tropicalis CE017: a new Brazilian enzymatic source for the bioreduction of aromatic prochiral ketones
title_sort Candida tropicalis CE017: a new Brazilian enzymatic source for the bioreduction of aromatic prochiral ketones
author Vieira,Gizelle A. B.
author_facet Vieira,Gizelle A. B.
Araujo,Daniel M. de Freitas
Lemos,Telma L. G.
Mattos,Marcos Carlos de
Oliveira,Maria da Conceição F. de
Melo,Vânia M. M.
Gonzalo,Gonzalo de
Gotor-Fernández,Vicente
Gotor,Vicente
author_role author
author2 Araujo,Daniel M. de Freitas
Lemos,Telma L. G.
Mattos,Marcos Carlos de
Oliveira,Maria da Conceição F. de
Melo,Vânia M. M.
Gonzalo,Gonzalo de
Gotor-Fernández,Vicente
Gotor,Vicente
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vieira,Gizelle A. B.
Araujo,Daniel M. de Freitas
Lemos,Telma L. G.
Mattos,Marcos Carlos de
Oliveira,Maria da Conceição F. de
Melo,Vânia M. M.
Gonzalo,Gonzalo de
Gotor-Fernández,Vicente
Gotor,Vicente
dc.subject.por.fl_str_mv alcohol dehydrogenases
biocatalysis
Candida tropicalis
ketones
yeast
topic alcohol dehydrogenases
biocatalysis
Candida tropicalis
ketones
yeast
description The reactivity and stereoselectivity showed by a new strain of Candida tropicalis in the reduction of prochiral ketones have been compared with the ones previously attained in our laboratory using microorganisms from the Brazilian biodiversity. In this manner, Candida tropicalis has demonstrated its versatility as stereoselective agent in the bioreduction of a series of aromatic ketones. These prochiral compounds were converted into their corresponding optically alcohols with moderate to excellent stereopreference depending on the substrate structure. Among ketones tested, nitroacetophenones were enzymatically reduced to enantiopure (S)-alcohol with complete conversion.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000800015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000800015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532010000800015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.21 n.8 2010
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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