Nanotechnology, Light and Chemical Action: an Effective Combination to Kill Cancer Cells
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015001202448 |
Resumo: | Photodynamic therapy (PDT) is a minimally invasive and effective procedure for treatment of cancer, based on the combination of a drug (photosensitizer, PS), light (visible or near-infrared, NIR) and induced local formation of reactive oxygen species (ROS) and radicals. Despite its less significant side effects as compared with conventional therapies, many efforts still are been focused on enhancing the selectivity and efficiency of PSs and thus, of commercial drugs. Nanotechnology is providing many interesting possibilities and tools to develop drug delivery systems (DDS) and multifunctional platforms for therapy, diagnosis and theranostics. More recently, their effectiveness against tumor cells and tissues is being improved by combining the synergic effects of chemotherapeutic agents and other therapies, making them more interesting therapeutic alternatives. Accordingly, this review is focused on the recent contributions of nanotechnology on PDT, converging to the development of DDSs and multifunctional systems and their application for cancer therapy. |
id |
SBQ-2_f70f01d1514632aa6137973549cd15e2 |
---|---|
oai_identifier_str |
oai:scielo:S0103-50532015001202448 |
network_acronym_str |
SBQ-2 |
network_name_str |
Journal of the Brazilian Chemical Society (Online) |
repository_id_str |
|
spelling |
Nanotechnology, Light and Chemical Action: an Effective Combination to Kill Cancer Cellsphotodynamic therapyphotosensitizerdrug delivery systemsnanocarrierscancerPhotodynamic therapy (PDT) is a minimally invasive and effective procedure for treatment of cancer, based on the combination of a drug (photosensitizer, PS), light (visible or near-infrared, NIR) and induced local formation of reactive oxygen species (ROS) and radicals. Despite its less significant side effects as compared with conventional therapies, many efforts still are been focused on enhancing the selectivity and efficiency of PSs and thus, of commercial drugs. Nanotechnology is providing many interesting possibilities and tools to develop drug delivery systems (DDS) and multifunctional platforms for therapy, diagnosis and theranostics. More recently, their effectiveness against tumor cells and tissues is being improved by combining the synergic effects of chemotherapeutic agents and other therapies, making them more interesting therapeutic alternatives. Accordingly, this review is focused on the recent contributions of nanotechnology on PDT, converging to the development of DDSs and multifunctional systems and their application for cancer therapy.Sociedade Brasileira de Química2015-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015001202448Journal of the Brazilian Chemical Society v.26 n.12 2015reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20150316info:eu-repo/semantics/openAccessDeda,Daiana K.Araki,Koitieng2015-12-16T00:00:00Zoai:scielo:S0103-50532015001202448Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2015-12-16T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Nanotechnology, Light and Chemical Action: an Effective Combination to Kill Cancer Cells |
title |
Nanotechnology, Light and Chemical Action: an Effective Combination to Kill Cancer Cells |
spellingShingle |
Nanotechnology, Light and Chemical Action: an Effective Combination to Kill Cancer Cells Deda,Daiana K. photodynamic therapy photosensitizer drug delivery systems nanocarriers cancer |
title_short |
Nanotechnology, Light and Chemical Action: an Effective Combination to Kill Cancer Cells |
title_full |
Nanotechnology, Light and Chemical Action: an Effective Combination to Kill Cancer Cells |
title_fullStr |
Nanotechnology, Light and Chemical Action: an Effective Combination to Kill Cancer Cells |
title_full_unstemmed |
Nanotechnology, Light and Chemical Action: an Effective Combination to Kill Cancer Cells |
title_sort |
Nanotechnology, Light and Chemical Action: an Effective Combination to Kill Cancer Cells |
author |
Deda,Daiana K. |
author_facet |
Deda,Daiana K. Araki,Koiti |
author_role |
author |
author2 |
Araki,Koiti |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Deda,Daiana K. Araki,Koiti |
dc.subject.por.fl_str_mv |
photodynamic therapy photosensitizer drug delivery systems nanocarriers cancer |
topic |
photodynamic therapy photosensitizer drug delivery systems nanocarriers cancer |
description |
Photodynamic therapy (PDT) is a minimally invasive and effective procedure for treatment of cancer, based on the combination of a drug (photosensitizer, PS), light (visible or near-infrared, NIR) and induced local formation of reactive oxygen species (ROS) and radicals. Despite its less significant side effects as compared with conventional therapies, many efforts still are been focused on enhancing the selectivity and efficiency of PSs and thus, of commercial drugs. Nanotechnology is providing many interesting possibilities and tools to develop drug delivery systems (DDS) and multifunctional platforms for therapy, diagnosis and theranostics. More recently, their effectiveness against tumor cells and tissues is being improved by combining the synergic effects of chemotherapeutic agents and other therapies, making them more interesting therapeutic alternatives. Accordingly, this review is focused on the recent contributions of nanotechnology on PDT, converging to the development of DDSs and multifunctional systems and their application for cancer therapy. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015001202448 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015001202448 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0103-5053.20150316 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.26 n.12 2015 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318177858879488 |