Natural product-like combinatorial libraries

Detalhes bibliográficos
Autor(a) principal: Abreu,Pedro M.
Data de Publicação: 2003
Outros Autores: Branco,Paula S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000500002
Resumo: Combinatorial chemistry has emerged over the last few years as an important tool for drug discovery and lead optimisation. In this approach, the molecular diversity and range of biological properties displayed by secondary metabolites constitutes a challenge to combinatorial strategies for natural products synthesis and derivatization. This article surveys the application of combinatorial techniques to the design of "natural product-looking" libraries covering a wide range of structural diversities.
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spelling Natural product-like combinatorial librariesnatural productscombinatorial chemistrydrug discoverylead compoundsCombinatorial chemistry has emerged over the last few years as an important tool for drug discovery and lead optimisation. In this approach, the molecular diversity and range of biological properties displayed by secondary metabolites constitutes a challenge to combinatorial strategies for natural products synthesis and derivatization. This article surveys the application of combinatorial techniques to the design of "natural product-looking" libraries covering a wide range of structural diversities.Sociedade Brasileira de Química2003-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000500002Journal of the Brazilian Chemical Society v.14 n.5 2003reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532003000500002info:eu-repo/semantics/openAccessAbreu,Pedro M.Branco,Paula S.eng2004-02-10T00:00:00Zoai:scielo:S0103-50532003000500002Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2004-02-10T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Natural product-like combinatorial libraries
title Natural product-like combinatorial libraries
spellingShingle Natural product-like combinatorial libraries
Abreu,Pedro M.
natural products
combinatorial chemistry
drug discovery
lead compounds
title_short Natural product-like combinatorial libraries
title_full Natural product-like combinatorial libraries
title_fullStr Natural product-like combinatorial libraries
title_full_unstemmed Natural product-like combinatorial libraries
title_sort Natural product-like combinatorial libraries
author Abreu,Pedro M.
author_facet Abreu,Pedro M.
Branco,Paula S.
author_role author
author2 Branco,Paula S.
author2_role author
dc.contributor.author.fl_str_mv Abreu,Pedro M.
Branco,Paula S.
dc.subject.por.fl_str_mv natural products
combinatorial chemistry
drug discovery
lead compounds
topic natural products
combinatorial chemistry
drug discovery
lead compounds
description Combinatorial chemistry has emerged over the last few years as an important tool for drug discovery and lead optimisation. In this approach, the molecular diversity and range of biological properties displayed by secondary metabolites constitutes a challenge to combinatorial strategies for natural products synthesis and derivatization. This article surveys the application of combinatorial techniques to the design of "natural product-looking" libraries covering a wide range of structural diversities.
publishDate 2003
dc.date.none.fl_str_mv 2003-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000500002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000500002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532003000500002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.14 n.5 2003
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
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reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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