Ibuprofen, Carbamazepine and β-Estradiol Determination Using Thin-Film Microextraction and Gas Chromatography-Mass Spectrometry
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016001001744 |
Resumo: | The use of thin-film microextraction for the extraction of selected pharmaceutical compounds followed by gas chromatography-mass spectrometry detection was evaluated. A segment of polysiloxanes polymer sheet was used as low cost, single use, disposable extraction phase, while Milli-Q water spiked at 20 µg L−1 with the analytes was used for the optimization assays. The controlling parameters for the extraction were optimized via experimental design and it was found that an extraction time of 3 h using a sample volume of 1000 mL at pH 4 with the addition of 20% methanol and 20% sodium chloride provided the greatest extraction efficiency. Recoveries between 67.1 and 85.0% were achieved, with a repeteability lower than 20% (expressed as coefficient of variation) and limit of detection ranged from 0.41 and 0.92 µg L−1. The proposed method show similar analytical performance when compared to the determination of the analytes using stir bar sorptive extraction. |
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Journal of the Brazilian Chemical Society (Online) |
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Ibuprofen, Carbamazepine and β-Estradiol Determination Using Thin-Film Microextraction and Gas Chromatography-Mass Spectrometrythin-film extractionβ-estradiolcarbamazepineibuprofenThe use of thin-film microextraction for the extraction of selected pharmaceutical compounds followed by gas chromatography-mass spectrometry detection was evaluated. A segment of polysiloxanes polymer sheet was used as low cost, single use, disposable extraction phase, while Milli-Q water spiked at 20 µg L−1 with the analytes was used for the optimization assays. The controlling parameters for the extraction were optimized via experimental design and it was found that an extraction time of 3 h using a sample volume of 1000 mL at pH 4 with the addition of 20% methanol and 20% sodium chloride provided the greatest extraction efficiency. Recoveries between 67.1 and 85.0% were achieved, with a repeteability lower than 20% (expressed as coefficient of variation) and limit of detection ranged from 0.41 and 0.92 µg L−1. The proposed method show similar analytical performance when compared to the determination of the analytes using stir bar sorptive extraction.Sociedade Brasileira de Química2016-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016001001744Journal of the Brazilian Chemical Society v.27 n.10 2016reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20160055info:eu-repo/semantics/openAccessGiordano,AdyVásquez,JoséRetamal,MauricioAscar,Loretoeng2016-10-04T00:00:00Zoai:scielo:S0103-50532016001001744Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2016-10-04T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Ibuprofen, Carbamazepine and β-Estradiol Determination Using Thin-Film Microextraction and Gas Chromatography-Mass Spectrometry |
title |
Ibuprofen, Carbamazepine and β-Estradiol Determination Using Thin-Film Microextraction and Gas Chromatography-Mass Spectrometry |
spellingShingle |
Ibuprofen, Carbamazepine and β-Estradiol Determination Using Thin-Film Microextraction and Gas Chromatography-Mass Spectrometry Giordano,Ady thin-film extraction β-estradiol carbamazepine ibuprofen |
title_short |
Ibuprofen, Carbamazepine and β-Estradiol Determination Using Thin-Film Microextraction and Gas Chromatography-Mass Spectrometry |
title_full |
Ibuprofen, Carbamazepine and β-Estradiol Determination Using Thin-Film Microextraction and Gas Chromatography-Mass Spectrometry |
title_fullStr |
Ibuprofen, Carbamazepine and β-Estradiol Determination Using Thin-Film Microextraction and Gas Chromatography-Mass Spectrometry |
title_full_unstemmed |
Ibuprofen, Carbamazepine and β-Estradiol Determination Using Thin-Film Microextraction and Gas Chromatography-Mass Spectrometry |
title_sort |
Ibuprofen, Carbamazepine and β-Estradiol Determination Using Thin-Film Microextraction and Gas Chromatography-Mass Spectrometry |
author |
Giordano,Ady |
author_facet |
Giordano,Ady Vásquez,José Retamal,Mauricio Ascar,Loreto |
author_role |
author |
author2 |
Vásquez,José Retamal,Mauricio Ascar,Loreto |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Giordano,Ady Vásquez,José Retamal,Mauricio Ascar,Loreto |
dc.subject.por.fl_str_mv |
thin-film extraction β-estradiol carbamazepine ibuprofen |
topic |
thin-film extraction β-estradiol carbamazepine ibuprofen |
description |
The use of thin-film microextraction for the extraction of selected pharmaceutical compounds followed by gas chromatography-mass spectrometry detection was evaluated. A segment of polysiloxanes polymer sheet was used as low cost, single use, disposable extraction phase, while Milli-Q water spiked at 20 µg L−1 with the analytes was used for the optimization assays. The controlling parameters for the extraction were optimized via experimental design and it was found that an extraction time of 3 h using a sample volume of 1000 mL at pH 4 with the addition of 20% methanol and 20% sodium chloride provided the greatest extraction efficiency. Recoveries between 67.1 and 85.0% were achieved, with a repeteability lower than 20% (expressed as coefficient of variation) and limit of detection ranged from 0.41 and 0.92 µg L−1. The proposed method show similar analytical performance when compared to the determination of the analytes using stir bar sorptive extraction. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016001001744 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016001001744 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0103-5053.20160055 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.27 n.10 2016 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318178742829056 |