Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tablets

Detalhes bibliográficos
Autor(a) principal: Salgado, Hérida Regina Nunes [UNESP]
Data de Publicação: 2005
Outros Autores: Oliveira, C. L. C. G. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.ingentaconnect.com/content/govi/pharmaz/2005/00000060/00000004/art00005
http://hdl.handle.net/11449/68192
Resumo: A simple, sensitive and accurate spectrophotometric method was developed for the assay of gatifloxacin in raw material and tablets. Validation of the method yielded good results concerning range, linearity, precision and accuracy. The absorbance was measured at 287 nm for gatifloxacin tablet solutions. The linearity range was found to be 4.0-14.0 μg/mL for gatifloxacin. It was also found that the excipients in the commercial tablets did not interfere with the method.
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spelling Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tabletsexcipientgatifloxacinquinoline derived antiinfective agentaccuracyanalytic methodaqueous solutioncalibrationcorrelation coefficientdrug determinationlinear regression analysisreproducibilitystatistical analysistablet formulationultraviolet spectrophotometryvalidation processAnti-Infective AgentsCalibrationFluoroquinolonesReference StandardsReproducibility of ResultsSpectrophotometry, UltravioletTabletsA simple, sensitive and accurate spectrophotometric method was developed for the assay of gatifloxacin in raw material and tablets. Validation of the method yielded good results concerning range, linearity, precision and accuracy. The absorbance was measured at 287 nm for gatifloxacin tablet solutions. The linearity range was found to be 4.0-14.0 μg/mL for gatifloxacin. It was also found that the excipients in the commercial tablets did not interfere with the method.Prog. Pos-Graduacao/Cie. Farmaceut. Faculdade de Ciencias Farmaceuticas Universidade Estadual Paulista, Araraquara SPDepto. Farmacos e Medicamentos Faculdade de Ciencias Farmaceuticas Universidade Estadual Paulista, Rodovia Araraquara-Jau,́ km1, CEP 14801-902, Araraquara-Sao PauloProg. Pos-Graduacao/Cie. Farmaceut. Faculdade de Ciencias Farmaceuticas Universidade Estadual Paulista, Araraquara SPDepto. Farmacos e Medicamentos Faculdade de Ciencias Farmaceuticas Universidade Estadual Paulista, Rodovia Araraquara-Jau,́ km1, CEP 14801-902, Araraquara-Sao PauloUniversidade Estadual Paulista (Unesp)Salgado, Hérida Regina Nunes [UNESP]Oliveira, C. L. C. G. [UNESP]2014-05-27T11:21:18Z2014-05-27T11:21:18Z2005-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article263-264http://www.ingentaconnect.com/content/govi/pharmaz/2005/00000060/00000004/art00005Pharmazie, v. 60, n. 4, p. 263-264, 2005.0031-7144http://hdl.handle.net/11449/68192WOS:0002285326000052-s2.0-17644362688Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmazie1.0160,375info:eu-repo/semantics/openAccess2024-06-24T13:46:44Zoai:repositorio.unesp.br:11449/68192Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-06T00:04:51.875820Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tablets
title Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tablets
spellingShingle Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tablets
Salgado, Hérida Regina Nunes [UNESP]
excipient
gatifloxacin
quinoline derived antiinfective agent
accuracy
analytic method
aqueous solution
calibration
correlation coefficient
drug determination
linear regression analysis
reproducibility
statistical analysis
tablet formulation
ultraviolet spectrophotometry
validation process
Anti-Infective Agents
Calibration
Fluoroquinolones
Reference Standards
Reproducibility of Results
Spectrophotometry, Ultraviolet
Tablets
title_short Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tablets
title_full Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tablets
title_fullStr Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tablets
title_full_unstemmed Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tablets
title_sort Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tablets
author Salgado, Hérida Regina Nunes [UNESP]
author_facet Salgado, Hérida Regina Nunes [UNESP]
Oliveira, C. L. C. G. [UNESP]
author_role author
author2 Oliveira, C. L. C. G. [UNESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Salgado, Hérida Regina Nunes [UNESP]
Oliveira, C. L. C. G. [UNESP]
dc.subject.por.fl_str_mv excipient
gatifloxacin
quinoline derived antiinfective agent
accuracy
analytic method
aqueous solution
calibration
correlation coefficient
drug determination
linear regression analysis
reproducibility
statistical analysis
tablet formulation
ultraviolet spectrophotometry
validation process
Anti-Infective Agents
Calibration
Fluoroquinolones
Reference Standards
Reproducibility of Results
Spectrophotometry, Ultraviolet
Tablets
topic excipient
gatifloxacin
quinoline derived antiinfective agent
accuracy
analytic method
aqueous solution
calibration
correlation coefficient
drug determination
linear regression analysis
reproducibility
statistical analysis
tablet formulation
ultraviolet spectrophotometry
validation process
Anti-Infective Agents
Calibration
Fluoroquinolones
Reference Standards
Reproducibility of Results
Spectrophotometry, Ultraviolet
Tablets
description A simple, sensitive and accurate spectrophotometric method was developed for the assay of gatifloxacin in raw material and tablets. Validation of the method yielded good results concerning range, linearity, precision and accuracy. The absorbance was measured at 287 nm for gatifloxacin tablet solutions. The linearity range was found to be 4.0-14.0 μg/mL for gatifloxacin. It was also found that the excipients in the commercial tablets did not interfere with the method.
publishDate 2005
dc.date.none.fl_str_mv 2005-04-01
2014-05-27T11:21:18Z
2014-05-27T11:21:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.ingentaconnect.com/content/govi/pharmaz/2005/00000060/00000004/art00005
Pharmazie, v. 60, n. 4, p. 263-264, 2005.
0031-7144
http://hdl.handle.net/11449/68192
WOS:000228532600005
2-s2.0-17644362688
url http://www.ingentaconnect.com/content/govi/pharmaz/2005/00000060/00000004/art00005
http://hdl.handle.net/11449/68192
identifier_str_mv Pharmazie, v. 60, n. 4, p. 263-264, 2005.
0031-7144
WOS:000228532600005
2-s2.0-17644362688
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pharmazie
1.016
0,375
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 263-264
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129580651773952

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