Chemical stability of enalapril maleate drug substance and tablets by a stability-indicating liquid chromatographic method
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000300016 |
Resumo: | The chemical stability of enalapril drug substance and tablets was studied by a stability-indicating liquid chromatographic method. Stress testing was performed on drug substance under various conditions. Accelerated stability testing was carried out for different formulations of enalapril tablets. Chromatographic separation was achieved on a RP-18 column, using a mobile phase of methanol phosphate buffer at 1.0 mL min"1 and UV detection. Degradation of the drug substance was greater under hydrolytic conditions. After 180 days of accelerated stability testing most enalapril tablets showed more than 10% of degradation. Enalapril drug substance and tablets showed instability under stress and accelerated testing respectively, with possible implications on the therapeutic activity. |
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Chemical stability of enalapril maleate drug substance and tablets by a stability-indicating liquid chromatographic methodenalaprilstabilityliquid chromatographyThe chemical stability of enalapril drug substance and tablets was studied by a stability-indicating liquid chromatographic method. Stress testing was performed on drug substance under various conditions. Accelerated stability testing was carried out for different formulations of enalapril tablets. Chromatographic separation was achieved on a RP-18 column, using a mobile phase of methanol phosphate buffer at 1.0 mL min"1 and UV detection. Degradation of the drug substance was greater under hydrolytic conditions. After 180 days of accelerated stability testing most enalapril tablets showed more than 10% of degradation. Enalapril drug substance and tablets showed instability under stress and accelerated testing respectively, with possible implications on the therapeutic activity.Sociedade Brasileira de Química2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000300016Química Nova v.34 n.3 2011reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422011000300016info:eu-repo/semantics/openAccessDiego,Marta deGodoy,GloriaMennickent,SigridGodoy,Ricardoeng2011-04-12T00:00:00Zoai:scielo:S0100-40422011000300016Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-04-12T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Chemical stability of enalapril maleate drug substance and tablets by a stability-indicating liquid chromatographic method |
title |
Chemical stability of enalapril maleate drug substance and tablets by a stability-indicating liquid chromatographic method |
spellingShingle |
Chemical stability of enalapril maleate drug substance and tablets by a stability-indicating liquid chromatographic method Diego,Marta de enalapril stability liquid chromatography |
title_short |
Chemical stability of enalapril maleate drug substance and tablets by a stability-indicating liquid chromatographic method |
title_full |
Chemical stability of enalapril maleate drug substance and tablets by a stability-indicating liquid chromatographic method |
title_fullStr |
Chemical stability of enalapril maleate drug substance and tablets by a stability-indicating liquid chromatographic method |
title_full_unstemmed |
Chemical stability of enalapril maleate drug substance and tablets by a stability-indicating liquid chromatographic method |
title_sort |
Chemical stability of enalapril maleate drug substance and tablets by a stability-indicating liquid chromatographic method |
author |
Diego,Marta de |
author_facet |
Diego,Marta de Godoy,Gloria Mennickent,Sigrid Godoy,Ricardo |
author_role |
author |
author2 |
Godoy,Gloria Mennickent,Sigrid Godoy,Ricardo |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Diego,Marta de Godoy,Gloria Mennickent,Sigrid Godoy,Ricardo |
dc.subject.por.fl_str_mv |
enalapril stability liquid chromatography |
topic |
enalapril stability liquid chromatography |
description |
The chemical stability of enalapril drug substance and tablets was studied by a stability-indicating liquid chromatographic method. Stress testing was performed on drug substance under various conditions. Accelerated stability testing was carried out for different formulations of enalapril tablets. Chromatographic separation was achieved on a RP-18 column, using a mobile phase of methanol phosphate buffer at 1.0 mL min"1 and UV detection. Degradation of the drug substance was greater under hydrolytic conditions. After 180 days of accelerated stability testing most enalapril tablets showed more than 10% of degradation. Enalapril drug substance and tablets showed instability under stress and accelerated testing respectively, with possible implications on the therapeutic activity. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000300016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000300016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-40422011000300016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.34 n.3 2011 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318111880380416 |