Semicarbazonas e tiossemicarbazonas: o amplo perfil farmacológico e usos clínicos

Detalhes bibliográficos
Autor(a) principal: Beraldo,Heloisa
Data de Publicação: 2004
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000300017
Resumo: This article shows that thiosemicarbazones, semicarbazones and their metal complexes can exhibit target selectivity along with a wide pharmacological profile. Complexes of thiosemicarbazones with cytotoxic or antitumoral activity are presented, some of which show activity against cisplatinum-resistant cells. The inhibition mechanism of the enzyme ribonucleoside diphosphate reductase (RDR), involved in DNA syntheses, by alpha(N)-heterocyclic thiosemicarbazones is discussed. The encouraging results of clinical trials with the RDR inhibitor 3-aminopyridine-2-carboxaldehyde thiosemicarbazone ("Triapine") against rapidly growing tumors are outlined. Examples are also given of thiosemicarbazones with antiviral and antimicrobial activity. The possible applications of semicarbazones as anticonvulsants with low toxicity and good therapeutic index are presented.
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spelling Semicarbazonas e tiossemicarbazonas: o amplo perfil farmacológico e usos clínicosthiosemicarbazonessemicarbazonespharmacological activityThis article shows that thiosemicarbazones, semicarbazones and their metal complexes can exhibit target selectivity along with a wide pharmacological profile. Complexes of thiosemicarbazones with cytotoxic or antitumoral activity are presented, some of which show activity against cisplatinum-resistant cells. The inhibition mechanism of the enzyme ribonucleoside diphosphate reductase (RDR), involved in DNA syntheses, by alpha(N)-heterocyclic thiosemicarbazones is discussed. The encouraging results of clinical trials with the RDR inhibitor 3-aminopyridine-2-carboxaldehyde thiosemicarbazone ("Triapine") against rapidly growing tumors are outlined. Examples are also given of thiosemicarbazones with antiviral and antimicrobial activity. The possible applications of semicarbazones as anticonvulsants with low toxicity and good therapeutic index are presented.Sociedade Brasileira de Química2004-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000300017Química Nova v.27 n.3 2004reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422004000300017info:eu-repo/semantics/openAccessBeraldo,Heloisapor2004-07-13T00:00:00Zoai:scielo:S0100-40422004000300017Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2004-07-13T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Semicarbazonas e tiossemicarbazonas: o amplo perfil farmacológico e usos clínicos
title Semicarbazonas e tiossemicarbazonas: o amplo perfil farmacológico e usos clínicos
spellingShingle Semicarbazonas e tiossemicarbazonas: o amplo perfil farmacológico e usos clínicos
Beraldo,Heloisa
thiosemicarbazones
semicarbazones
pharmacological activity
title_short Semicarbazonas e tiossemicarbazonas: o amplo perfil farmacológico e usos clínicos
title_full Semicarbazonas e tiossemicarbazonas: o amplo perfil farmacológico e usos clínicos
title_fullStr Semicarbazonas e tiossemicarbazonas: o amplo perfil farmacológico e usos clínicos
title_full_unstemmed Semicarbazonas e tiossemicarbazonas: o amplo perfil farmacológico e usos clínicos
title_sort Semicarbazonas e tiossemicarbazonas: o amplo perfil farmacológico e usos clínicos
author Beraldo,Heloisa
author_facet Beraldo,Heloisa
author_role author
dc.contributor.author.fl_str_mv Beraldo,Heloisa
dc.subject.por.fl_str_mv thiosemicarbazones
semicarbazones
pharmacological activity
topic thiosemicarbazones
semicarbazones
pharmacological activity
description This article shows that thiosemicarbazones, semicarbazones and their metal complexes can exhibit target selectivity along with a wide pharmacological profile. Complexes of thiosemicarbazones with cytotoxic or antitumoral activity are presented, some of which show activity against cisplatinum-resistant cells. The inhibition mechanism of the enzyme ribonucleoside diphosphate reductase (RDR), involved in DNA syntheses, by alpha(N)-heterocyclic thiosemicarbazones is discussed. The encouraging results of clinical trials with the RDR inhibitor 3-aminopyridine-2-carboxaldehyde thiosemicarbazone ("Triapine") against rapidly growing tumors are outlined. Examples are also given of thiosemicarbazones with antiviral and antimicrobial activity. The possible applications of semicarbazones as anticonvulsants with low toxicity and good therapeutic index are presented.
publishDate 2004
dc.date.none.fl_str_mv 2004-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000300017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000300017
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422004000300017
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.27 n.3 2004
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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