Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies

Detalhes bibliográficos
Autor(a) principal: Mello,Vanessa Azevedo de
Data de Publicação: 2011
Outros Autores: Ricci-Júnior,Eduardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000600004
Resumo: Nanoparticles were produced by solvent emulsification evaporation method with the following characteristics: nanometric size (238 ± 3 nm), narrow polydispersity index (0.11), negative zeta potential (-15.1 mV), good yield of the process (73 ± 1.5%), excellent encapsulation efficiency (81.3 ± 4.2%) and spherical shape. X-rays diffraction demonstrated the loss of drug crystallinity after encapsulation; however, the profile of the diffractograms of the poly-ε-caprolactone (PCL) nanoparticles was kept. Differential scanning calorimetry thermograms, correspondingly, exhibited the loss of drug melting peak and the increasing of the melting point of the PCL nanoparticles, evidencing an interaction drug-polymer. Naproxen release was low and sustained obeying the Higuchi´s kinetic. The results show that nanoparticles are promising sustained release system to the naproxen.
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spelling Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studiesnaproxennanoparticlesstructure characterizationNanoparticles were produced by solvent emulsification evaporation method with the following characteristics: nanometric size (238 ± 3 nm), narrow polydispersity index (0.11), negative zeta potential (-15.1 mV), good yield of the process (73 ± 1.5%), excellent encapsulation efficiency (81.3 ± 4.2%) and spherical shape. X-rays diffraction demonstrated the loss of drug crystallinity after encapsulation; however, the profile of the diffractograms of the poly-ε-caprolactone (PCL) nanoparticles was kept. Differential scanning calorimetry thermograms, correspondingly, exhibited the loss of drug melting peak and the increasing of the melting point of the PCL nanoparticles, evidencing an interaction drug-polymer. Naproxen release was low and sustained obeying the Higuchi´s kinetic. The results show that nanoparticles are promising sustained release system to the naproxen.Sociedade Brasileira de Química2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000600004Química Nova v.34 n.6 2011reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422011000600004info:eu-repo/semantics/openAccessMello,Vanessa Azevedo deRicci-Júnior,Eduardoeng2011-08-01T00:00:00Zoai:scielo:S0100-40422011000600004Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-08-01T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies
title Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies
spellingShingle Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies
Mello,Vanessa Azevedo de
naproxen
nanoparticles
structure characterization
title_short Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies
title_full Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies
title_fullStr Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies
title_full_unstemmed Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies
title_sort Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies
author Mello,Vanessa Azevedo de
author_facet Mello,Vanessa Azevedo de
Ricci-Júnior,Eduardo
author_role author
author2 Ricci-Júnior,Eduardo
author2_role author
dc.contributor.author.fl_str_mv Mello,Vanessa Azevedo de
Ricci-Júnior,Eduardo
dc.subject.por.fl_str_mv naproxen
nanoparticles
structure characterization
topic naproxen
nanoparticles
structure characterization
description Nanoparticles were produced by solvent emulsification evaporation method with the following characteristics: nanometric size (238 ± 3 nm), narrow polydispersity index (0.11), negative zeta potential (-15.1 mV), good yield of the process (73 ± 1.5%), excellent encapsulation efficiency (81.3 ± 4.2%) and spherical shape. X-rays diffraction demonstrated the loss of drug crystallinity after encapsulation; however, the profile of the diffractograms of the poly-ε-caprolactone (PCL) nanoparticles was kept. Differential scanning calorimetry thermograms, correspondingly, exhibited the loss of drug melting peak and the increasing of the melting point of the PCL nanoparticles, evidencing an interaction drug-polymer. Naproxen release was low and sustained obeying the Higuchi´s kinetic. The results show that nanoparticles are promising sustained release system to the naproxen.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000600004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000600004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422011000600004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.34 n.6 2011
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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