Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studies

Detalhes bibliográficos
Autor(a) principal: Paroha,Shweta
Data de Publicação: 2014
Outros Autores: Dubey,Ravindra Dhar, Mallick,Subrata
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000100015
Resumo: Interaction and physicochemical characterization of dispersions of naproxen in calcium carbonate after freeze-drying the wet-state equilibrated mixture have been investigated by analytical methods. The FT-IR study revealed the acid-base reaction between naproxen and calcium carbonate. The DSC study indicated physical interaction and significantly diminished crystallinity of naproxen in the formulation containing higher quantities of calcium carbonate. Furthermore, the SEM study showed the reduced particle size and loss of crystalline morphology in the same sample. Drug release increased with the increase of calcium carbonate in the formulations. Formulation of naproxen with calcium carbonate in 1:2 ratio allowed its dissolution to the greatest extent (94.96%) while other compositions, 1:0.5 and 1:1, showed 80.86% and 78.30% release, respectively.
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spelling Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studiesnaproxencalcium carbonatein vitro dissolutionInteraction and physicochemical characterization of dispersions of naproxen in calcium carbonate after freeze-drying the wet-state equilibrated mixture have been investigated by analytical methods. The FT-IR study revealed the acid-base reaction between naproxen and calcium carbonate. The DSC study indicated physical interaction and significantly diminished crystallinity of naproxen in the formulation containing higher quantities of calcium carbonate. Furthermore, the SEM study showed the reduced particle size and loss of crystalline morphology in the same sample. Drug release increased with the increase of calcium carbonate in the formulations. Formulation of naproxen with calcium carbonate in 1:2 ratio allowed its dissolution to the greatest extent (94.96%) while other compositions, 1:0.5 and 1:1, showed 80.86% and 78.30% release, respectively.Sociedade Brasileira de Química2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000100015Química Nova v.37 n.1 2014reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422014000100015info:eu-repo/semantics/openAccessParoha,ShwetaDubey,Ravindra DharMallick,Subrataeng2014-02-18T00:00:00Zoai:scielo:S0100-40422014000100015Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2014-02-18T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studies
title Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studies
spellingShingle Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studies
Paroha,Shweta
naproxen
calcium carbonate
in vitro dissolution
title_short Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studies
title_full Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studies
title_fullStr Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studies
title_full_unstemmed Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studies
title_sort Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studies
author Paroha,Shweta
author_facet Paroha,Shweta
Dubey,Ravindra Dhar
Mallick,Subrata
author_role author
author2 Dubey,Ravindra Dhar
Mallick,Subrata
author2_role author
author
dc.contributor.author.fl_str_mv Paroha,Shweta
Dubey,Ravindra Dhar
Mallick,Subrata
dc.subject.por.fl_str_mv naproxen
calcium carbonate
in vitro dissolution
topic naproxen
calcium carbonate
in vitro dissolution
description Interaction and physicochemical characterization of dispersions of naproxen in calcium carbonate after freeze-drying the wet-state equilibrated mixture have been investigated by analytical methods. The FT-IR study revealed the acid-base reaction between naproxen and calcium carbonate. The DSC study indicated physical interaction and significantly diminished crystallinity of naproxen in the formulation containing higher quantities of calcium carbonate. Furthermore, the SEM study showed the reduced particle size and loss of crystalline morphology in the same sample. Drug release increased with the increase of calcium carbonate in the formulations. Formulation of naproxen with calcium carbonate in 1:2 ratio allowed its dissolution to the greatest extent (94.96%) while other compositions, 1:0.5 and 1:1, showed 80.86% and 78.30% release, respectively.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000100015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000100015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422014000100015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.37 n.1 2014
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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