Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada

Detalhes bibliográficos
Autor(a) principal: Cordeiro,Gilcélia A.
Data de Publicação: 2008
Outros Autores: Peralta-Zamora,Patricio, Nagata,Noemi, Pontarollo,Roberto
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200012
Resumo: In this work a multivariate spectroscopic methodology is proposed for quantitative determination of sulfamethoxazole and trimethoprim in pharmaceutical associations. The multivariate model was developed by partial least-squares regression, using twenty synthetic mixtures and the spectral region between 190 and 350 nm. In the validation stage, which involved the analysis of five synthetic mixtures, prediction errors lower that 3% were observed. The predictive capacity of the multivariate models is seriously affected by spectral changes induced by pH variations, a fact that acquires a great significance in the analysis of real samples (pharmaceuticals) that contain chemical additives.
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spelling Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariadasulfamethoxazole-trimethoprimmultivariate calibrationelectronic spectroscopyIn this work a multivariate spectroscopic methodology is proposed for quantitative determination of sulfamethoxazole and trimethoprim in pharmaceutical associations. The multivariate model was developed by partial least-squares regression, using twenty synthetic mixtures and the spectral region between 190 and 350 nm. In the validation stage, which involved the analysis of five synthetic mixtures, prediction errors lower that 3% were observed. The predictive capacity of the multivariate models is seriously affected by spectral changes induced by pH variations, a fact that acquires a great significance in the analysis of real samples (pharmaceuticals) that contain chemical additives.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200012Química Nova v.31 n.2 2008reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422008000200012info:eu-repo/semantics/openAccessCordeiro,Gilcélia A.Peralta-Zamora,PatricioNagata,NoemiPontarollo,Robertopor2009-09-25T00:00:00Zoai:scielo:S0100-40422008000200012Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2009-09-25T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada
title Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada
spellingShingle Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada
Cordeiro,Gilcélia A.
sulfamethoxazole-trimethoprim
multivariate calibration
electronic spectroscopy
title_short Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada
title_full Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada
title_fullStr Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada
title_full_unstemmed Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada
title_sort Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada
author Cordeiro,Gilcélia A.
author_facet Cordeiro,Gilcélia A.
Peralta-Zamora,Patricio
Nagata,Noemi
Pontarollo,Roberto
author_role author
author2 Peralta-Zamora,Patricio
Nagata,Noemi
Pontarollo,Roberto
author2_role author
author
author
dc.contributor.author.fl_str_mv Cordeiro,Gilcélia A.
Peralta-Zamora,Patricio
Nagata,Noemi
Pontarollo,Roberto
dc.subject.por.fl_str_mv sulfamethoxazole-trimethoprim
multivariate calibration
electronic spectroscopy
topic sulfamethoxazole-trimethoprim
multivariate calibration
electronic spectroscopy
description In this work a multivariate spectroscopic methodology is proposed for quantitative determination of sulfamethoxazole and trimethoprim in pharmaceutical associations. The multivariate model was developed by partial least-squares regression, using twenty synthetic mixtures and the spectral region between 190 and 350 nm. In the validation stage, which involved the analysis of five synthetic mixtures, prediction errors lower that 3% were observed. The predictive capacity of the multivariate models is seriously affected by spectral changes induced by pH variations, a fact that acquires a great significance in the analysis of real samples (pharmaceuticals) that contain chemical additives.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200012
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422008000200012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.31 n.2 2008
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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