Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200012 |
Resumo: | In this work a multivariate spectroscopic methodology is proposed for quantitative determination of sulfamethoxazole and trimethoprim in pharmaceutical associations. The multivariate model was developed by partial least-squares regression, using twenty synthetic mixtures and the spectral region between 190 and 350 nm. In the validation stage, which involved the analysis of five synthetic mixtures, prediction errors lower that 3% were observed. The predictive capacity of the multivariate models is seriously affected by spectral changes induced by pH variations, a fact that acquires a great significance in the analysis of real samples (pharmaceuticals) that contain chemical additives. |
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Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariadasulfamethoxazole-trimethoprimmultivariate calibrationelectronic spectroscopyIn this work a multivariate spectroscopic methodology is proposed for quantitative determination of sulfamethoxazole and trimethoprim in pharmaceutical associations. The multivariate model was developed by partial least-squares regression, using twenty synthetic mixtures and the spectral region between 190 and 350 nm. In the validation stage, which involved the analysis of five synthetic mixtures, prediction errors lower that 3% were observed. The predictive capacity of the multivariate models is seriously affected by spectral changes induced by pH variations, a fact that acquires a great significance in the analysis of real samples (pharmaceuticals) that contain chemical additives.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200012Química Nova v.31 n.2 2008reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422008000200012info:eu-repo/semantics/openAccessCordeiro,Gilcélia A.Peralta-Zamora,PatricioNagata,NoemiPontarollo,Robertopor2009-09-25T00:00:00Zoai:scielo:S0100-40422008000200012Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2009-09-25T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada |
title |
Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada |
spellingShingle |
Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada Cordeiro,Gilcélia A. sulfamethoxazole-trimethoprim multivariate calibration electronic spectroscopy |
title_short |
Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada |
title_full |
Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada |
title_fullStr |
Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada |
title_full_unstemmed |
Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada |
title_sort |
Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada |
author |
Cordeiro,Gilcélia A. |
author_facet |
Cordeiro,Gilcélia A. Peralta-Zamora,Patricio Nagata,Noemi Pontarollo,Roberto |
author_role |
author |
author2 |
Peralta-Zamora,Patricio Nagata,Noemi Pontarollo,Roberto |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Cordeiro,Gilcélia A. Peralta-Zamora,Patricio Nagata,Noemi Pontarollo,Roberto |
dc.subject.por.fl_str_mv |
sulfamethoxazole-trimethoprim multivariate calibration electronic spectroscopy |
topic |
sulfamethoxazole-trimethoprim multivariate calibration electronic spectroscopy |
description |
In this work a multivariate spectroscopic methodology is proposed for quantitative determination of sulfamethoxazole and trimethoprim in pharmaceutical associations. The multivariate model was developed by partial least-squares regression, using twenty synthetic mixtures and the spectral region between 190 and 350 nm. In the validation stage, which involved the analysis of five synthetic mixtures, prediction errors lower that 3% were observed. The predictive capacity of the multivariate models is seriously affected by spectral changes induced by pH variations, a fact that acquires a great significance in the analysis of real samples (pharmaceuticals) that contain chemical additives. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200012 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200012 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
10.1590/S0100-40422008000200012 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.31 n.2 2008 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318107236237312 |