Heterociclos 1,2,3-triazólicos: histórico, métodos de preparação, aplicações e atividades farmacológicas

Detalhes bibliográficos
Autor(a) principal: Melo,Júlio O. F.
Data de Publicação: 2006
Outros Autores: Donnici,Claudio Luis, Augusti,Rodinei, Ferreira,Vitor F., Souza,Maria Cecília B. V. de, Ferreira,Maria Lourdes G., Cunha,Anna C.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000300028
Resumo: The 1,2,3-triazole, known since the end of 19th century, is a very widely used heterocyclic system present in many synthetic substances and commercial pharmaceutical compounds. In fact, 1,2,3-triazoles show several applications in many areas especially as medicines against many diseases like cancer, AIDS, Parkinson and Alzheimer. Nowadays there is a large variety of known methods to obtain these heterocyclic compounds comprising mainly three synthetic routes. Nevertheless, there is no article that gives an objective overview of the synthetic methods for obtaining these kinds of azoheterocycles. This paper presents a brief history of this class of compounds, and a synthetic discussion concerning the main synthetic methods for its preparation, such as cyclization through hydrazones, concerted cycloadditon [2+3] and pseudopericyclic cyclization - and some others of restricted application, but also important. Finally, this paper also provides a brief overview on pharmacological applications of some 1,2,3-triazoles.
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spelling Heterociclos 1,2,3-triazólicos: histórico, métodos de preparação, aplicações e atividades farmacológicas1,2,3-triazolessynthesisapplicationsThe 1,2,3-triazole, known since the end of 19th century, is a very widely used heterocyclic system present in many synthetic substances and commercial pharmaceutical compounds. In fact, 1,2,3-triazoles show several applications in many areas especially as medicines against many diseases like cancer, AIDS, Parkinson and Alzheimer. Nowadays there is a large variety of known methods to obtain these heterocyclic compounds comprising mainly three synthetic routes. Nevertheless, there is no article that gives an objective overview of the synthetic methods for obtaining these kinds of azoheterocycles. This paper presents a brief history of this class of compounds, and a synthetic discussion concerning the main synthetic methods for its preparation, such as cyclization through hydrazones, concerted cycloadditon [2+3] and pseudopericyclic cyclization - and some others of restricted application, but also important. Finally, this paper also provides a brief overview on pharmacological applications of some 1,2,3-triazoles.Sociedade Brasileira de Química2006-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000300028Química Nova v.29 n.3 2006reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422006000300028info:eu-repo/semantics/openAccessMelo,Júlio O. F.Donnici,Claudio LuisAugusti,RodineiFerreira,Vitor F.Souza,Maria Cecília B. V. deFerreira,Maria Lourdes G.Cunha,Anna C.por2006-05-25T00:00:00Zoai:scielo:S0100-40422006000300028Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2006-05-25T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Heterociclos 1,2,3-triazólicos: histórico, métodos de preparação, aplicações e atividades farmacológicas
title Heterociclos 1,2,3-triazólicos: histórico, métodos de preparação, aplicações e atividades farmacológicas
spellingShingle Heterociclos 1,2,3-triazólicos: histórico, métodos de preparação, aplicações e atividades farmacológicas
Melo,Júlio O. F.
1,2,3-triazoles
synthesis
applications
title_short Heterociclos 1,2,3-triazólicos: histórico, métodos de preparação, aplicações e atividades farmacológicas
title_full Heterociclos 1,2,3-triazólicos: histórico, métodos de preparação, aplicações e atividades farmacológicas
title_fullStr Heterociclos 1,2,3-triazólicos: histórico, métodos de preparação, aplicações e atividades farmacológicas
title_full_unstemmed Heterociclos 1,2,3-triazólicos: histórico, métodos de preparação, aplicações e atividades farmacológicas
title_sort Heterociclos 1,2,3-triazólicos: histórico, métodos de preparação, aplicações e atividades farmacológicas
author Melo,Júlio O. F.
author_facet Melo,Júlio O. F.
Donnici,Claudio Luis
Augusti,Rodinei
Ferreira,Vitor F.
Souza,Maria Cecília B. V. de
Ferreira,Maria Lourdes G.
Cunha,Anna C.
author_role author
author2 Donnici,Claudio Luis
Augusti,Rodinei
Ferreira,Vitor F.
Souza,Maria Cecília B. V. de
Ferreira,Maria Lourdes G.
Cunha,Anna C.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Melo,Júlio O. F.
Donnici,Claudio Luis
Augusti,Rodinei
Ferreira,Vitor F.
Souza,Maria Cecília B. V. de
Ferreira,Maria Lourdes G.
Cunha,Anna C.
dc.subject.por.fl_str_mv 1,2,3-triazoles
synthesis
applications
topic 1,2,3-triazoles
synthesis
applications
description The 1,2,3-triazole, known since the end of 19th century, is a very widely used heterocyclic system present in many synthetic substances and commercial pharmaceutical compounds. In fact, 1,2,3-triazoles show several applications in many areas especially as medicines against many diseases like cancer, AIDS, Parkinson and Alzheimer. Nowadays there is a large variety of known methods to obtain these heterocyclic compounds comprising mainly three synthetic routes. Nevertheless, there is no article that gives an objective overview of the synthetic methods for obtaining these kinds of azoheterocycles. This paper presents a brief history of this class of compounds, and a synthetic discussion concerning the main synthetic methods for its preparation, such as cyclization through hydrazones, concerted cycloadditon [2+3] and pseudopericyclic cyclization - and some others of restricted application, but also important. Finally, this paper also provides a brief overview on pharmacological applications of some 1,2,3-triazoles.
publishDate 2006
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dc.language.iso.fl_str_mv por
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dc.relation.none.fl_str_mv 10.1590/S0100-40422006000300028
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.29 n.3 2006
reponame:Química Nova (Online)
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reponame_str Química Nova (Online)
collection Química Nova (Online)
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