Improvement of genistein content in solid genistein/-cyclodextrin complexes β

Detalhes bibliográficos
Autor(a) principal: Xavier,Clarissa R.
Data de Publicação: 2010
Outros Autores: Silva,Ana Paula C., Schwingel,Liege C., Borghetti,Greice S., Koester,Letícia S., Mayorga,Paulo, Teixeira,Helder F., Bassani,Valquiria L., Lula,Ivana S., Sinisterra,Rubén D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000300019
Resumo: Genistein:β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combined with molecular modeling. According to the results obtained, the interaction of genistein with β -cyclodextrin in a 1:1 complex is supposed to occur mainly through the insertion of the guest A-ring in cyclodextrin cavity, without rule out the possibility of inclusion through the B-ring, as previously reported in the literature.
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spelling Improvement of genistein content in solid genistein/-cyclodextrin complexes βgenisteincyclodextrincomputer molecular mechanicsGenistein:β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combined with molecular modeling. According to the results obtained, the interaction of genistein with β -cyclodextrin in a 1:1 complex is supposed to occur mainly through the insertion of the guest A-ring in cyclodextrin cavity, without rule out the possibility of inclusion through the B-ring, as previously reported in the literature.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000300019Química Nova v.33 n.3 2010reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422010000300019info:eu-repo/semantics/openAccessXavier,Clarissa R.Silva,Ana Paula C.Schwingel,Liege C.Borghetti,Greice S.Koester,Letícia S.Mayorga,PauloTeixeira,Helder F.Bassani,Valquiria L.Lula,Ivana S.Sinisterra,Rubén D.eng2010-04-19T00:00:00Zoai:scielo:S0100-40422010000300019Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2010-04-19T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Improvement of genistein content in solid genistein/-cyclodextrin complexes β
title Improvement of genistein content in solid genistein/-cyclodextrin complexes β
spellingShingle Improvement of genistein content in solid genistein/-cyclodextrin complexes β
Xavier,Clarissa R.
genistein
cyclodextrin
computer molecular mechanics
title_short Improvement of genistein content in solid genistein/-cyclodextrin complexes β
title_full Improvement of genistein content in solid genistein/-cyclodextrin complexes β
title_fullStr Improvement of genistein content in solid genistein/-cyclodextrin complexes β
title_full_unstemmed Improvement of genistein content in solid genistein/-cyclodextrin complexes β
title_sort Improvement of genistein content in solid genistein/-cyclodextrin complexes β
author Xavier,Clarissa R.
author_facet Xavier,Clarissa R.
Silva,Ana Paula C.
Schwingel,Liege C.
Borghetti,Greice S.
Koester,Letícia S.
Mayorga,Paulo
Teixeira,Helder F.
Bassani,Valquiria L.
Lula,Ivana S.
Sinisterra,Rubén D.
author_role author
author2 Silva,Ana Paula C.
Schwingel,Liege C.
Borghetti,Greice S.
Koester,Letícia S.
Mayorga,Paulo
Teixeira,Helder F.
Bassani,Valquiria L.
Lula,Ivana S.
Sinisterra,Rubén D.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Xavier,Clarissa R.
Silva,Ana Paula C.
Schwingel,Liege C.
Borghetti,Greice S.
Koester,Letícia S.
Mayorga,Paulo
Teixeira,Helder F.
Bassani,Valquiria L.
Lula,Ivana S.
Sinisterra,Rubén D.
dc.subject.por.fl_str_mv genistein
cyclodextrin
computer molecular mechanics
topic genistein
cyclodextrin
computer molecular mechanics
description Genistein:β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combined with molecular modeling. According to the results obtained, the interaction of genistein with β -cyclodextrin in a 1:1 complex is supposed to occur mainly through the insertion of the guest A-ring in cyclodextrin cavity, without rule out the possibility of inclusion through the B-ring, as previously reported in the literature.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000300019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000300019
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422010000300019
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.33 n.3 2010
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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