Improvement of genistein content in solid genistein/β-cyclodextrin complexes
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFRGS |
| Texto Completo: | http://hdl.handle.net/10183/72883 |
Resumo: | Genistein: β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combined with molecular modeling. According to the results obtained, the interaction of genistein with β-cyclodextrin in a 1:1 complex is supposed to occur mainly through the insertion of the guest A-ring in cyclodextrin cavity, without rule out the possibility of inclusion through the B-ring, as previously reported in the literature. |
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Xavier, Clarissa RuaroSilva, Ana Paula CappraSchwingel, Liege CassiaBorghetti, Greice StefaniKoester, Leticia SchererMayorga Borges, Paulo EduardoTeixeira, Helder FerreiraBassani, Valquiria LinckLula, IvanaSinisterra, Ruben Dario2013-07-02T01:43:21Z20100100-4042http://hdl.handle.net/10183/72883000752046Genistein: β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combined with molecular modeling. According to the results obtained, the interaction of genistein with β-cyclodextrin in a 1:1 complex is supposed to occur mainly through the insertion of the guest A-ring in cyclodextrin cavity, without rule out the possibility of inclusion through the B-ring, as previously reported in the literature.application/pdfengQuímica nova. São Paulo. Vol. 33, n. 3 (2010), p. 587-590GenisteínaCiclodextrinaIsoflavonas : Grao de sojaComplexaçãoGenisteinβ-cyclodextrinComputer molecular mechanicsImprovement of genistein content in solid genistein/β-cyclodextrin complexesinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000752046.pdf000752046.pdfTexto completo (inglês)application/pdf704826http://www.lume.ufrgs.br/bitstream/10183/72883/1/000752046.pdf08b24981c61e1be065f4fe82aa9da954MD51TEXT000752046.pdf.txt000752046.pdf.txtExtracted Texttext/plain17303http://www.lume.ufrgs.br/bitstream/10183/72883/2/000752046.pdf.txtaaab604215c31f82078969144ed08072MD52THUMBNAIL000752046.pdf.jpg000752046.pdf.jpgGenerated Thumbnailimage/jpeg1924http://www.lume.ufrgs.br/bitstream/10183/72883/3/000752046.pdf.jpg06a582075ed8f557500609bf0496e505MD5310183/728832019-06-19 02:34:13.612207oai:www.lume.ufrgs.br:10183/72883Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-06-19T05:34:13Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
| dc.title.pt_BR.fl_str_mv |
Improvement of genistein content in solid genistein/β-cyclodextrin complexes |
| title |
Improvement of genistein content in solid genistein/β-cyclodextrin complexes |
| spellingShingle |
Improvement of genistein content in solid genistein/β-cyclodextrin complexes Xavier, Clarissa Ruaro Genisteína Ciclodextrina Isoflavonas : Grao de soja Complexação Genistein β-cyclodextrin Computer molecular mechanics |
| title_short |
Improvement of genistein content in solid genistein/β-cyclodextrin complexes |
| title_full |
Improvement of genistein content in solid genistein/β-cyclodextrin complexes |
| title_fullStr |
Improvement of genistein content in solid genistein/β-cyclodextrin complexes |
| title_full_unstemmed |
Improvement of genistein content in solid genistein/β-cyclodextrin complexes |
| title_sort |
Improvement of genistein content in solid genistein/β-cyclodextrin complexes |
| author |
Xavier, Clarissa Ruaro |
| author_facet |
Xavier, Clarissa Ruaro Silva, Ana Paula Cappra Schwingel, Liege Cassia Borghetti, Greice Stefani Koester, Leticia Scherer Mayorga Borges, Paulo Eduardo Teixeira, Helder Ferreira Bassani, Valquiria Linck Lula, Ivana Sinisterra, Ruben Dario |
| author_role |
author |
| author2 |
Silva, Ana Paula Cappra Schwingel, Liege Cassia Borghetti, Greice Stefani Koester, Leticia Scherer Mayorga Borges, Paulo Eduardo Teixeira, Helder Ferreira Bassani, Valquiria Linck Lula, Ivana Sinisterra, Ruben Dario |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Xavier, Clarissa Ruaro Silva, Ana Paula Cappra Schwingel, Liege Cassia Borghetti, Greice Stefani Koester, Leticia Scherer Mayorga Borges, Paulo Eduardo Teixeira, Helder Ferreira Bassani, Valquiria Linck Lula, Ivana Sinisterra, Ruben Dario |
| dc.subject.por.fl_str_mv |
Genisteína Ciclodextrina Isoflavonas : Grao de soja Complexação |
| topic |
Genisteína Ciclodextrina Isoflavonas : Grao de soja Complexação Genistein β-cyclodextrin Computer molecular mechanics |
| dc.subject.eng.fl_str_mv |
Genistein β-cyclodextrin Computer molecular mechanics |
| description |
Genistein: β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combined with molecular modeling. According to the results obtained, the interaction of genistein with β-cyclodextrin in a 1:1 complex is supposed to occur mainly through the insertion of the guest A-ring in cyclodextrin cavity, without rule out the possibility of inclusion through the B-ring, as previously reported in the literature. |
| publishDate |
2010 |
| dc.date.issued.fl_str_mv |
2010 |
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2013-07-02T01:43:21Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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article |
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publishedVersion |
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http://hdl.handle.net/10183/72883 |
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0100-4042 |
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000752046 |
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http://hdl.handle.net/10183/72883 |
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eng |
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eng |
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Química nova. São Paulo. Vol. 33, n. 3 (2010), p. 587-590 |
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