Modelos estereoquímicos de adição à carbonila
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422017000300342 |
Resumo: | The stereochemical control in the generation of new stereogenic centers is of paramount importance in organic chemistry. In this context, diastereoselective additions to carbonyl compounds bearing a stereogenic center at the α-position are of particular importance, since an increase in molecular complexity can be achieved by constructing a new bond, together with the introduction of a new stereocenter. Despite the relevance of the topic, it is discussed only briefly in several of the most popular organic chemistry textbooks, or not discussed at all. The present article intends to discuss the evolution of stereochemical models for 1,2-induction and present to students a tool to understand and predict the stereochemical outcome of addition of nucleophiles to aldehydes and ketones bearing a stereogenic center at the α-position. |
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Modelos estereoquímicos de adição à carbonilastereochemistrydiastereoselectivitycarbonyl compoundsFelkin-AnhCram-chelateThe stereochemical control in the generation of new stereogenic centers is of paramount importance in organic chemistry. In this context, diastereoselective additions to carbonyl compounds bearing a stereogenic center at the α-position are of particular importance, since an increase in molecular complexity can be achieved by constructing a new bond, together with the introduction of a new stereocenter. Despite the relevance of the topic, it is discussed only briefly in several of the most popular organic chemistry textbooks, or not discussed at all. The present article intends to discuss the evolution of stereochemical models for 1,2-induction and present to students a tool to understand and predict the stereochemical outcome of addition of nucleophiles to aldehydes and ketones bearing a stereogenic center at the α-position.Sociedade Brasileira de Química2017-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422017000300342Química Nova v.40 n.3 2017reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20160186info:eu-repo/semantics/openAccessMartins,Bruna S.Lüdtke,Diogo S.Moro,Angélica Venturinipor2017-05-05T00:00:00Zoai:scielo:S0100-40422017000300342Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2017-05-05T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Modelos estereoquímicos de adição à carbonila |
title |
Modelos estereoquímicos de adição à carbonila |
spellingShingle |
Modelos estereoquímicos de adição à carbonila Martins,Bruna S. stereochemistry diastereoselectivity carbonyl compounds Felkin-Anh Cram-chelate |
title_short |
Modelos estereoquímicos de adição à carbonila |
title_full |
Modelos estereoquímicos de adição à carbonila |
title_fullStr |
Modelos estereoquímicos de adição à carbonila |
title_full_unstemmed |
Modelos estereoquímicos de adição à carbonila |
title_sort |
Modelos estereoquímicos de adição à carbonila |
author |
Martins,Bruna S. |
author_facet |
Martins,Bruna S. Lüdtke,Diogo S. Moro,Angélica Venturini |
author_role |
author |
author2 |
Lüdtke,Diogo S. Moro,Angélica Venturini |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Martins,Bruna S. Lüdtke,Diogo S. Moro,Angélica Venturini |
dc.subject.por.fl_str_mv |
stereochemistry diastereoselectivity carbonyl compounds Felkin-Anh Cram-chelate |
topic |
stereochemistry diastereoselectivity carbonyl compounds Felkin-Anh Cram-chelate |
description |
The stereochemical control in the generation of new stereogenic centers is of paramount importance in organic chemistry. In this context, diastereoselective additions to carbonyl compounds bearing a stereogenic center at the α-position are of particular importance, since an increase in molecular complexity can be achieved by constructing a new bond, together with the introduction of a new stereocenter. Despite the relevance of the topic, it is discussed only briefly in several of the most popular organic chemistry textbooks, or not discussed at all. The present article intends to discuss the evolution of stereochemical models for 1,2-induction and present to students a tool to understand and predict the stereochemical outcome of addition of nucleophiles to aldehydes and ketones bearing a stereogenic center at the α-position. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422017000300342 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422017000300342 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
10.21577/0100-4042.20160186 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.40 n.3 2017 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318118018744320 |