Degradação e estabilização do diclofenaco em nanocápsulas poliméricas

Detalhes bibliográficos
Autor(a) principal: Müller,Claudia Regina
Data de Publicação: 2004
Outros Autores: Haas,Sandra Elisa, Bassani,Valquíria Linck, Guterres,Sílvia Stanisçuaski, Fessi,Hatem, Peralba,Maria do Carmo R., Pohlmann,Adriana Raffin
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000400008
Resumo: The parameters which affect the degradation and stabilization of diclofenac in suspensions of nanocapsules and of the corresponding spray-dried powders were investigated. Formulations were subjected to 14 months of storage at room temperature. In addition, a study of the degradation of diclofenac was carried out by exposing the formulations or mixtures (drug and adjuvants) to UVC wavelengths. The presence of Epikuron 170® in a concentration higher than 3.06 mg/mL stabilizes the drug, avoiding its reduction or degradation. The degradation products were isolated, analyzed by gas chromatography-mass spectrometry, and identified as 2-(2',6'-dichlorophenyl)aminobenzyl alcohol and N-(2',6'-dichlorophenyl)anthranilylaldehyde.
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spelling Degradação e estabilização do diclofenaco em nanocápsulas poliméricasnanoparticlesdiclofenacdegradationThe parameters which affect the degradation and stabilization of diclofenac in suspensions of nanocapsules and of the corresponding spray-dried powders were investigated. Formulations were subjected to 14 months of storage at room temperature. In addition, a study of the degradation of diclofenac was carried out by exposing the formulations or mixtures (drug and adjuvants) to UVC wavelengths. The presence of Epikuron 170® in a concentration higher than 3.06 mg/mL stabilizes the drug, avoiding its reduction or degradation. The degradation products were isolated, analyzed by gas chromatography-mass spectrometry, and identified as 2-(2',6'-dichlorophenyl)aminobenzyl alcohol and N-(2',6'-dichlorophenyl)anthranilylaldehyde.Sociedade Brasileira de Química2004-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000400008Química Nova v.27 n.4 2004reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422004000400008info:eu-repo/semantics/openAccessMüller,Claudia ReginaHaas,Sandra ElisaBassani,Valquíria LinckGuterres,Sílvia StanisçuaskiFessi,HatemPeralba,Maria do Carmo R.Pohlmann,Adriana Raffinpor2004-07-31T00:00:00Zoai:scielo:S0100-40422004000400008Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2004-07-31T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
title Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
spellingShingle Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
Müller,Claudia Regina
nanoparticles
diclofenac
degradation
title_short Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
title_full Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
title_fullStr Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
title_full_unstemmed Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
title_sort Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
author Müller,Claudia Regina
author_facet Müller,Claudia Regina
Haas,Sandra Elisa
Bassani,Valquíria Linck
Guterres,Sílvia Stanisçuaski
Fessi,Hatem
Peralba,Maria do Carmo R.
Pohlmann,Adriana Raffin
author_role author
author2 Haas,Sandra Elisa
Bassani,Valquíria Linck
Guterres,Sílvia Stanisçuaski
Fessi,Hatem
Peralba,Maria do Carmo R.
Pohlmann,Adriana Raffin
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Müller,Claudia Regina
Haas,Sandra Elisa
Bassani,Valquíria Linck
Guterres,Sílvia Stanisçuaski
Fessi,Hatem
Peralba,Maria do Carmo R.
Pohlmann,Adriana Raffin
dc.subject.por.fl_str_mv nanoparticles
diclofenac
degradation
topic nanoparticles
diclofenac
degradation
description The parameters which affect the degradation and stabilization of diclofenac in suspensions of nanocapsules and of the corresponding spray-dried powders were investigated. Formulations were subjected to 14 months of storage at room temperature. In addition, a study of the degradation of diclofenac was carried out by exposing the formulations or mixtures (drug and adjuvants) to UVC wavelengths. The presence of Epikuron 170® in a concentration higher than 3.06 mg/mL stabilizes the drug, avoiding its reduction or degradation. The degradation products were isolated, analyzed by gas chromatography-mass spectrometry, and identified as 2-(2',6'-dichlorophenyl)aminobenzyl alcohol and N-(2',6'-dichlorophenyl)anthranilylaldehyde.
publishDate 2004
dc.date.none.fl_str_mv 2004-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000400008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000400008
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422004000400008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.27 n.4 2004
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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