Degradação e estabilização do diclofenaco em nanocápsulas poliméricas

Detalhes bibliográficos
Autor(a) principal: Muller, Claudia Regina
Data de Publicação: 2004
Outros Autores: Haas, Sandra Elisa, Bassani, Valquiria Linck, Guterres, Silvia Stanisçuaski, Fessi, H., Peralba, Maria do Carmo Ruaro, Pohlmann, Adriana Raffin
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/72987
Resumo: The parameters which affect the degradation and stabilization of diclofenac in suspensions of nanocapsules and of the corresponding spray-dried powders were investigated. Formulations were subjected to 14 months of storage at room temperature. In addition, a study of the degradation of diclofenac was carried out by exposing the formulations or mixtures (drug and adjuvants) to UVC wavelengths. The presence of Epikuron 170® in a concentration higher than 3.06 mg/mL stabilizes the drug, avoiding its reduction or degradation. The degradation products were isolated, analyzed by gas chromatography-mass spectrometry, and identified as 2-(2’,6’- dichlorophenyl)aminobenzyl alcohol and N-(2’,6’-dichlorophenyl)anthranilylaldehyde.
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spelling Muller, Claudia ReginaHaas, Sandra ElisaBassani, Valquiria LinckGuterres, Silvia StanisçuaskiFessi, H.Peralba, Maria do Carmo RuaroPohlmann, Adriana Raffin2013-07-03T01:42:48Z20040100-4042http://hdl.handle.net/10183/72987000424352The parameters which affect the degradation and stabilization of diclofenac in suspensions of nanocapsules and of the corresponding spray-dried powders were investigated. Formulations were subjected to 14 months of storage at room temperature. In addition, a study of the degradation of diclofenac was carried out by exposing the formulations or mixtures (drug and adjuvants) to UVC wavelengths. The presence of Epikuron 170® in a concentration higher than 3.06 mg/mL stabilizes the drug, avoiding its reduction or degradation. The degradation products were isolated, analyzed by gas chromatography-mass spectrometry, and identified as 2-(2’,6’- dichlorophenyl)aminobenzyl alcohol and N-(2’,6’-dichlorophenyl)anthranilylaldehyde.application/pdfporQuímica nova. São Paulo. Vol. 27, n. 4 (2004), p. 555-560DiclofenacoNanocápsulasDegradaçãoFarmacologiaNanoparticlesDiclofenacDegradationDegradação e estabilização do diclofenaco em nanocápsulas poliméricasDegradation and stabilization of diclofenac in polymeric nanocapsules info:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000424352.pdf000424352.pdfTexto completoapplication/pdf200561http://www.lume.ufrgs.br/bitstream/10183/72987/1/000424352.pdfb994600282a18a73a1b6cd22437fe0eaMD51TEXT000424352.pdf.txt000424352.pdf.txtExtracted Texttext/plain38279http://www.lume.ufrgs.br/bitstream/10183/72987/2/000424352.pdf.txt9b3dc350cf9fd382584c8deb2a5f0029MD52THUMBNAIL000424352.pdf.jpg000424352.pdf.jpgGenerated Thumbnailimage/jpeg1939http://www.lume.ufrgs.br/bitstream/10183/72987/3/000424352.pdf.jpgfa4d4e33ed53b241e025e633ce3333efMD5310183/729872019-12-28 05:04:22.290726oai:www.lume.ufrgs.br:10183/72987Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-12-28T07:04:22Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
dc.title.alternative.en.fl_str_mv Degradation and stabilization of diclofenac in polymeric nanocapsules
title Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
spellingShingle Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
Muller, Claudia Regina
Diclofenaco
Nanocápsulas
Degradação
Farmacologia
Nanoparticles
Diclofenac
Degradation
title_short Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
title_full Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
title_fullStr Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
title_full_unstemmed Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
title_sort Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
author Muller, Claudia Regina
author_facet Muller, Claudia Regina
Haas, Sandra Elisa
Bassani, Valquiria Linck
Guterres, Silvia Stanisçuaski
Fessi, H.
Peralba, Maria do Carmo Ruaro
Pohlmann, Adriana Raffin
author_role author
author2 Haas, Sandra Elisa
Bassani, Valquiria Linck
Guterres, Silvia Stanisçuaski
Fessi, H.
Peralba, Maria do Carmo Ruaro
Pohlmann, Adriana Raffin
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Muller, Claudia Regina
Haas, Sandra Elisa
Bassani, Valquiria Linck
Guterres, Silvia Stanisçuaski
Fessi, H.
Peralba, Maria do Carmo Ruaro
Pohlmann, Adriana Raffin
dc.subject.por.fl_str_mv Diclofenaco
Nanocápsulas
Degradação
Farmacologia
topic Diclofenaco
Nanocápsulas
Degradação
Farmacologia
Nanoparticles
Diclofenac
Degradation
dc.subject.eng.fl_str_mv Nanoparticles
Diclofenac
Degradation
description The parameters which affect the degradation and stabilization of diclofenac in suspensions of nanocapsules and of the corresponding spray-dried powders were investigated. Formulations were subjected to 14 months of storage at room temperature. In addition, a study of the degradation of diclofenac was carried out by exposing the formulations or mixtures (drug and adjuvants) to UVC wavelengths. The presence of Epikuron 170® in a concentration higher than 3.06 mg/mL stabilizes the drug, avoiding its reduction or degradation. The degradation products were isolated, analyzed by gas chromatography-mass spectrometry, and identified as 2-(2’,6’- dichlorophenyl)aminobenzyl alcohol and N-(2’,6’-dichlorophenyl)anthranilylaldehyde.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2013-07-03T01:42:48Z
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dc.relation.ispartof.pt_BR.fl_str_mv Química nova. São Paulo. Vol. 27, n. 4 (2004), p. 555-560
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