Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000700002 |
Resumo: | The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil® and Glibetab®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 µm. For the in vitro dissolution test Daonil® at 45 min showed a Q > 70%, whereas Glibetab® and glibenclamide calcium-alginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties. |
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Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beadsglibenclamidecalcium-alginate beadsdissolutionThe aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil® and Glibetab®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 µm. For the in vitro dissolution test Daonil® at 45 min showed a Q > 70%, whereas Glibetab® and glibenclamide calcium-alginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000700002Química Nova v.33 n.7 2010reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422010000700002info:eu-repo/semantics/openAccessCharles-Navarro,DaliaBocanegra-García,VirgilioPalos,IsidroRivera,GildardoEsquivel-Ferriño,PatriciaGracia-Vásquez,SandraOrtiz-Andrade,RolffyQuiroz-Velásquez,JesúsHernández-Mendoza,José Luiseng2010-09-27T00:00:00Zoai:scielo:S0100-40422010000700002Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2010-09-27T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads |
title |
Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads |
spellingShingle |
Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads Charles-Navarro,Dalia glibenclamide calcium-alginate beads dissolution |
title_short |
Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads |
title_full |
Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads |
title_fullStr |
Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads |
title_full_unstemmed |
Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads |
title_sort |
Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads |
author |
Charles-Navarro,Dalia |
author_facet |
Charles-Navarro,Dalia Bocanegra-García,Virgilio Palos,Isidro Rivera,Gildardo Esquivel-Ferriño,Patricia Gracia-Vásquez,Sandra Ortiz-Andrade,Rolffy Quiroz-Velásquez,Jesús Hernández-Mendoza,José Luis |
author_role |
author |
author2 |
Bocanegra-García,Virgilio Palos,Isidro Rivera,Gildardo Esquivel-Ferriño,Patricia Gracia-Vásquez,Sandra Ortiz-Andrade,Rolffy Quiroz-Velásquez,Jesús Hernández-Mendoza,José Luis |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Charles-Navarro,Dalia Bocanegra-García,Virgilio Palos,Isidro Rivera,Gildardo Esquivel-Ferriño,Patricia Gracia-Vásquez,Sandra Ortiz-Andrade,Rolffy Quiroz-Velásquez,Jesús Hernández-Mendoza,José Luis |
dc.subject.por.fl_str_mv |
glibenclamide calcium-alginate beads dissolution |
topic |
glibenclamide calcium-alginate beads dissolution |
description |
The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil® and Glibetab®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 µm. For the in vitro dissolution test Daonil® at 45 min showed a Q > 70%, whereas Glibetab® and glibenclamide calcium-alginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000700002 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000700002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-40422010000700002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.33 n.7 2010 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318111076122624 |