Dissolution test for glibenclamide tablets

Detalhes bibliográficos
Autor(a) principal: Gianotto,Elisabeth Aparecida dos Santos
Data de Publicação: 2007
Outros Autores: Arantes,Renata Pires, Lara-Filho,Maurilio José, Casimiro Filho,Alexandre Cezar Saraiva, Fregonezi-Nery,Marlene Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000500031
Resumo: The aim of this work is to develop and validate a dissolution test for glibenclamide tablets. Optimal conditions to carry out the dissolution test are 500 mL of phosphate buffer at pH 8.0, paddles at 75 rpm stirring speed, time test set to 60 min and using equipment with six vessels. The derivative UV spectrophotometric method for determination of glibenclamide released was developed, validated and compared with the HPLC method. The UVDS method presents linearity (r² = 0.9999) in the concentration range of 5-14 µg/mL. Precision and recoveries were 0.42% and 100.25%, respectively. The method was applied to three products commercially available on the Brazilian market.
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spelling Dissolution test for glibenclamide tabletsglibenclamidedissolution testultraviolet derivative spectrophotometryThe aim of this work is to develop and validate a dissolution test for glibenclamide tablets. Optimal conditions to carry out the dissolution test are 500 mL of phosphate buffer at pH 8.0, paddles at 75 rpm stirring speed, time test set to 60 min and using equipment with six vessels. The derivative UV spectrophotometric method for determination of glibenclamide released was developed, validated and compared with the HPLC method. The UVDS method presents linearity (r² = 0.9999) in the concentration range of 5-14 µg/mL. Precision and recoveries were 0.42% and 100.25%, respectively. The method was applied to three products commercially available on the Brazilian market.Sociedade Brasileira de Química2007-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000500031Química Nova v.30 n.5 2007reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422007000500031info:eu-repo/semantics/openAccessGianotto,Elisabeth Aparecida dos SantosArantes,Renata PiresLara-Filho,Maurilio JoséCasimiro Filho,Alexandre Cezar SaraivaFregonezi-Nery,Marlene Mariaeng2007-09-28T00:00:00Zoai:scielo:S0100-40422007000500031Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2007-09-28T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Dissolution test for glibenclamide tablets
title Dissolution test for glibenclamide tablets
spellingShingle Dissolution test for glibenclamide tablets
Gianotto,Elisabeth Aparecida dos Santos
glibenclamide
dissolution test
ultraviolet derivative spectrophotometry
title_short Dissolution test for glibenclamide tablets
title_full Dissolution test for glibenclamide tablets
title_fullStr Dissolution test for glibenclamide tablets
title_full_unstemmed Dissolution test for glibenclamide tablets
title_sort Dissolution test for glibenclamide tablets
author Gianotto,Elisabeth Aparecida dos Santos
author_facet Gianotto,Elisabeth Aparecida dos Santos
Arantes,Renata Pires
Lara-Filho,Maurilio José
Casimiro Filho,Alexandre Cezar Saraiva
Fregonezi-Nery,Marlene Maria
author_role author
author2 Arantes,Renata Pires
Lara-Filho,Maurilio José
Casimiro Filho,Alexandre Cezar Saraiva
Fregonezi-Nery,Marlene Maria
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gianotto,Elisabeth Aparecida dos Santos
Arantes,Renata Pires
Lara-Filho,Maurilio José
Casimiro Filho,Alexandre Cezar Saraiva
Fregonezi-Nery,Marlene Maria
dc.subject.por.fl_str_mv glibenclamide
dissolution test
ultraviolet derivative spectrophotometry
topic glibenclamide
dissolution test
ultraviolet derivative spectrophotometry
description The aim of this work is to develop and validate a dissolution test for glibenclamide tablets. Optimal conditions to carry out the dissolution test are 500 mL of phosphate buffer at pH 8.0, paddles at 75 rpm stirring speed, time test set to 60 min and using equipment with six vessels. The derivative UV spectrophotometric method for determination of glibenclamide released was developed, validated and compared with the HPLC method. The UVDS method presents linearity (r² = 0.9999) in the concentration range of 5-14 µg/mL. Precision and recoveries were 0.42% and 100.25%, respectively. The method was applied to three products commercially available on the Brazilian market.
publishDate 2007
dc.date.none.fl_str_mv 2007-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000500031
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000500031
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422007000500031
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.30 n.5 2007
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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