Glicoalcaloides antifúngicos, flavonoides e outros constituintes químicos de Solanum asperum

• Autor(a) principal: Pinto,Francisco das Chagas L.
• Data de Publicação: 2011
• Outros Autores: Uchoa,Daniel Esdras de A., Silveira,Edilberto R., Pessoa,Otília Deusdênia L., Braz-Filho,Raimundo, Silva,Fernanda M. e, Theodoro,Phellipe N. E. T., Espíndola,Laila S.
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Química Nova (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000200021
• topic: Solanum asperum; antifungal glycoalkaloids; flavonoids

Two glycoalkaloids: solamargine and solasonine; three flavonoids: tiliroside, 7-O-α-L-ramnopyranosyl-kaempferol and 3-O-[ß-D-glucopyranosyl-(1→6)-α-L-ramnopyranosyl]-7- O-α-L-ramnopyranosyl-kaempferol, in addition to the tripeptide Leu-Ile-Val, the aminoacid proline and the eicosanoic acid were isolated from Solanum asperum (Solanaceae). The structures of all compounds were determined by interpretation of their spectra (IR, MS, ¹H and 13C NMR) and comparison with the literature data. All compounds, except the glycoalkaloids, are being reported for the first time for S. asperum. Solasonine showed strong activity (MIC < 0.24 μg/mL) against four filamentous fungi species of the genera Microsporum and Trichophyton.