Heavy atom enhanced room-temperature phosphorimetry for ultratrace determination of harmane

Detalhes bibliográficos
Autor(a) principal: Marques,Flávia F. de Carvalho
Data de Publicação: 2008
Outros Autores: Figueiredo,Flávia da Silva, Aucelio,Ricardo Queiroz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200003
Resumo: Harmane has been proposed for the treatment of epilepsy, AIDS and leshmaniosis. Its room-temperature phosphorescence was induced using either AgNO3 or TlNO3, enabling absolute limits of detection of 0.12 and 2.4 ng respectively, with linear dynamic ranges extending up to 456 ng (AgNO3) and 911 ng (TlNO3). Relative standard deviations around 3% were observed for substrates containing 46 ng of harmane. Such sensitivity and precision are needed because harmane intake must be strictly controlled to achieve proper therapeutic response. Interference studies were performed using thalidomide, reserpine and yohimbine. Recovery of 104±6% was achieved using solid surface room-temperature phosphorimetry. The result was comparable to the one obtained by micellar electrokinetic chromatography.
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spelling Heavy atom enhanced room-temperature phosphorimetry for ultratrace determination of harmaneroom-temperature phosphorescenceharmaneselective heavy atom effectHarmane has been proposed for the treatment of epilepsy, AIDS and leshmaniosis. Its room-temperature phosphorescence was induced using either AgNO3 or TlNO3, enabling absolute limits of detection of 0.12 and 2.4 ng respectively, with linear dynamic ranges extending up to 456 ng (AgNO3) and 911 ng (TlNO3). Relative standard deviations around 3% were observed for substrates containing 46 ng of harmane. Such sensitivity and precision are needed because harmane intake must be strictly controlled to achieve proper therapeutic response. Interference studies were performed using thalidomide, reserpine and yohimbine. Recovery of 104±6% was achieved using solid surface room-temperature phosphorimetry. The result was comparable to the one obtained by micellar electrokinetic chromatography.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200003Química Nova v.31 n.2 2008reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422008000200003info:eu-repo/semantics/openAccessMarques,Flávia F. de CarvalhoFigueiredo,Flávia da SilvaAucelio,Ricardo Queirozeng2009-09-25T00:00:00Zoai:scielo:S0100-40422008000200003Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2009-09-25T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Heavy atom enhanced room-temperature phosphorimetry for ultratrace determination of harmane
title Heavy atom enhanced room-temperature phosphorimetry for ultratrace determination of harmane
spellingShingle Heavy atom enhanced room-temperature phosphorimetry for ultratrace determination of harmane
Marques,Flávia F. de Carvalho
room-temperature phosphorescence
harmane
selective heavy atom effect
title_short Heavy atom enhanced room-temperature phosphorimetry for ultratrace determination of harmane
title_full Heavy atom enhanced room-temperature phosphorimetry for ultratrace determination of harmane
title_fullStr Heavy atom enhanced room-temperature phosphorimetry for ultratrace determination of harmane
title_full_unstemmed Heavy atom enhanced room-temperature phosphorimetry for ultratrace determination of harmane
title_sort Heavy atom enhanced room-temperature phosphorimetry for ultratrace determination of harmane
author Marques,Flávia F. de Carvalho
author_facet Marques,Flávia F. de Carvalho
Figueiredo,Flávia da Silva
Aucelio,Ricardo Queiroz
author_role author
author2 Figueiredo,Flávia da Silva
Aucelio,Ricardo Queiroz
author2_role author
author
dc.contributor.author.fl_str_mv Marques,Flávia F. de Carvalho
Figueiredo,Flávia da Silva
Aucelio,Ricardo Queiroz
dc.subject.por.fl_str_mv room-temperature phosphorescence
harmane
selective heavy atom effect
topic room-temperature phosphorescence
harmane
selective heavy atom effect
description Harmane has been proposed for the treatment of epilepsy, AIDS and leshmaniosis. Its room-temperature phosphorescence was induced using either AgNO3 or TlNO3, enabling absolute limits of detection of 0.12 and 2.4 ng respectively, with linear dynamic ranges extending up to 456 ng (AgNO3) and 911 ng (TlNO3). Relative standard deviations around 3% were observed for substrates containing 46 ng of harmane. Such sensitivity and precision are needed because harmane intake must be strictly controlled to achieve proper therapeutic response. Interference studies were performed using thalidomide, reserpine and yohimbine. Recovery of 104±6% was achieved using solid surface room-temperature phosphorimetry. The result was comparable to the one obtained by micellar electrokinetic chromatography.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422008000200003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.31 n.2 2008
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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