Development and validation of a dissolution test for diltiazem hydrochloride in immediate release capsules

Detalhes bibliográficos
Autor(a) principal: Mendonça,Taciane Ferreira
Data de Publicação: 2011
Outros Autores: Barros,Eliézer Giannini de, Pereira,Gislaine Ribeiro, Araújo,Magali Benjamim de, Bonfilio,Rudy
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000300027
Resumo: This work describes the development and validation of a dissolution test for 60 mg of diltiazem hydrochloride in immediate release capsules. The best dissolution in vitro profile was achieved using potassium phosphate buffer at pH 6.8 as the dissolution medium and paddle as the apparatus at 50 rpm. The drug concentrations in the dissolution media were determined by UV spectrophotometry and HPLC and a statistical analysis revealed that there were significant differences between HPLC and spectrophotometry. This study illustrates the importance of an official method for the dissolution test, since there is no official monograph for diltiazem hydrochloride in capsules.
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spelling Development and validation of a dissolution test for diltiazem hydrochloride in immediate release capsulesdissolutionhigh performance liquid chromatographyspectrophotometryThis work describes the development and validation of a dissolution test for 60 mg of diltiazem hydrochloride in immediate release capsules. The best dissolution in vitro profile was achieved using potassium phosphate buffer at pH 6.8 as the dissolution medium and paddle as the apparatus at 50 rpm. The drug concentrations in the dissolution media were determined by UV spectrophotometry and HPLC and a statistical analysis revealed that there were significant differences between HPLC and spectrophotometry. This study illustrates the importance of an official method for the dissolution test, since there is no official monograph for diltiazem hydrochloride in capsules.Sociedade Brasileira de Química2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000300027Química Nova v.34 n.3 2011reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422011000300027info:eu-repo/semantics/openAccessMendonça,Taciane FerreiraBarros,Eliézer Giannini dePereira,Gislaine RibeiroAraújo,Magali Benjamim deBonfilio,Rudyeng2011-04-12T00:00:00Zoai:scielo:S0100-40422011000300027Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-04-12T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Development and validation of a dissolution test for diltiazem hydrochloride in immediate release capsules
title Development and validation of a dissolution test for diltiazem hydrochloride in immediate release capsules
spellingShingle Development and validation of a dissolution test for diltiazem hydrochloride in immediate release capsules
Mendonça,Taciane Ferreira
dissolution
high performance liquid chromatography
spectrophotometry
title_short Development and validation of a dissolution test for diltiazem hydrochloride in immediate release capsules
title_full Development and validation of a dissolution test for diltiazem hydrochloride in immediate release capsules
title_fullStr Development and validation of a dissolution test for diltiazem hydrochloride in immediate release capsules
title_full_unstemmed Development and validation of a dissolution test for diltiazem hydrochloride in immediate release capsules
title_sort Development and validation of a dissolution test for diltiazem hydrochloride in immediate release capsules
author Mendonça,Taciane Ferreira
author_facet Mendonça,Taciane Ferreira
Barros,Eliézer Giannini de
Pereira,Gislaine Ribeiro
Araújo,Magali Benjamim de
Bonfilio,Rudy
author_role author
author2 Barros,Eliézer Giannini de
Pereira,Gislaine Ribeiro
Araújo,Magali Benjamim de
Bonfilio,Rudy
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Mendonça,Taciane Ferreira
Barros,Eliézer Giannini de
Pereira,Gislaine Ribeiro
Araújo,Magali Benjamim de
Bonfilio,Rudy
dc.subject.por.fl_str_mv dissolution
high performance liquid chromatography
spectrophotometry
topic dissolution
high performance liquid chromatography
spectrophotometry
description This work describes the development and validation of a dissolution test for 60 mg of diltiazem hydrochloride in immediate release capsules. The best dissolution in vitro profile was achieved using potassium phosphate buffer at pH 6.8 as the dissolution medium and paddle as the apparatus at 50 rpm. The drug concentrations in the dissolution media were determined by UV spectrophotometry and HPLC and a statistical analysis revealed that there were significant differences between HPLC and spectrophotometry. This study illustrates the importance of an official method for the dissolution test, since there is no official monograph for diltiazem hydrochloride in capsules.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000300027
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000300027
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422011000300027
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.34 n.3 2011
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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