COCRISTAIS: UMA ESTRATÉGIA PROMISSORA NA ÁREA FARMACÊUTICA

Detalhes bibliográficos
Autor(a) principal: Rocha,Alanny B. O.
Data de Publicação: 2016
Outros Autores: Kuminek,Gislaine, Machado,Tatiane C., Rosa,Juliana, Rauber,Gabriela S., Borba,Paola A. A., Siedler,Sana, Stulzer,Hellen K., Cuffini,Silvia Lucia, Rodríguez-Hornedo,Naír, Cardoso,Simone G.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422016000901112
Resumo: Pharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability. Aqueous cocrystal solubility can be orders of magnitude higher than that of the constituent drug and this solubility advantage can be fine-tuned based on environmental conditions such as pH and the presence of drug solubilizing agents. This review presents a brief overview of pharmaceutical cocrystals regarding cocrystal design, obtainment methods, with particular focus on cocrystal solubility, and the solubility modulation by solution phase chemistry.
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spelling COCRISTAIS: UMA ESTRATÉGIA PROMISSORA NA ÁREA FARMACÊUTICAcocrystalsdrugsolubilitytransition pointthermodynamic stabilityPharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability. Aqueous cocrystal solubility can be orders of magnitude higher than that of the constituent drug and this solubility advantage can be fine-tuned based on environmental conditions such as pH and the presence of drug solubilizing agents. This review presents a brief overview of pharmaceutical cocrystals regarding cocrystal design, obtainment methods, with particular focus on cocrystal solubility, and the solubility modulation by solution phase chemistry.Sociedade Brasileira de Química2016-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422016000901112Química Nova v.39 n.9 2016reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20160139info:eu-repo/semantics/openAccessRocha,Alanny B. O.Kuminek,GislaineMachado,Tatiane C.Rosa,JulianaRauber,Gabriela S.Borba,Paola A. A.Siedler,SanaStulzer,Hellen K.Cuffini,Silvia LuciaRodríguez-Hornedo,NaírCardoso,Simone G.por2016-11-23T00:00:00Zoai:scielo:S0100-40422016000901112Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2016-11-23T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv COCRISTAIS: UMA ESTRATÉGIA PROMISSORA NA ÁREA FARMACÊUTICA
title COCRISTAIS: UMA ESTRATÉGIA PROMISSORA NA ÁREA FARMACÊUTICA
spellingShingle COCRISTAIS: UMA ESTRATÉGIA PROMISSORA NA ÁREA FARMACÊUTICA
Rocha,Alanny B. O.
cocrystals
drug
solubility
transition point
thermodynamic stability
title_short COCRISTAIS: UMA ESTRATÉGIA PROMISSORA NA ÁREA FARMACÊUTICA
title_full COCRISTAIS: UMA ESTRATÉGIA PROMISSORA NA ÁREA FARMACÊUTICA
title_fullStr COCRISTAIS: UMA ESTRATÉGIA PROMISSORA NA ÁREA FARMACÊUTICA
title_full_unstemmed COCRISTAIS: UMA ESTRATÉGIA PROMISSORA NA ÁREA FARMACÊUTICA
title_sort COCRISTAIS: UMA ESTRATÉGIA PROMISSORA NA ÁREA FARMACÊUTICA
author Rocha,Alanny B. O.
author_facet Rocha,Alanny B. O.
Kuminek,Gislaine
Machado,Tatiane C.
Rosa,Juliana
Rauber,Gabriela S.
Borba,Paola A. A.
Siedler,Sana
Stulzer,Hellen K.
Cuffini,Silvia Lucia
Rodríguez-Hornedo,Naír
Cardoso,Simone G.
author_role author
author2 Kuminek,Gislaine
Machado,Tatiane C.
Rosa,Juliana
Rauber,Gabriela S.
Borba,Paola A. A.
Siedler,Sana
Stulzer,Hellen K.
Cuffini,Silvia Lucia
Rodríguez-Hornedo,Naír
Cardoso,Simone G.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rocha,Alanny B. O.
Kuminek,Gislaine
Machado,Tatiane C.
Rosa,Juliana
Rauber,Gabriela S.
Borba,Paola A. A.
Siedler,Sana
Stulzer,Hellen K.
Cuffini,Silvia Lucia
Rodríguez-Hornedo,Naír
Cardoso,Simone G.
dc.subject.por.fl_str_mv cocrystals
drug
solubility
transition point
thermodynamic stability
topic cocrystals
drug
solubility
transition point
thermodynamic stability
description Pharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability. Aqueous cocrystal solubility can be orders of magnitude higher than that of the constituent drug and this solubility advantage can be fine-tuned based on environmental conditions such as pH and the presence of drug solubilizing agents. This review presents a brief overview of pharmaceutical cocrystals regarding cocrystal design, obtainment methods, with particular focus on cocrystal solubility, and the solubility modulation by solution phase chemistry.
publishDate 2016
dc.date.none.fl_str_mv 2016-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422016000901112
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422016000901112
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.21577/0100-4042.20160139
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.39 n.9 2016
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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