Cocristais: uma estratégia promissora na área farmacêutica
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.21577/0100-4042.20160139 https://repositorio.unifesp.br/handle/11600/56777 |
Resumo: | Pharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability. Aqueous cocrystal solubility can be orders of magnitude higher than that of the constituent drug and this solubility advantage can be fine-tuned based on environmental conditions such as pH and the presence of drug solubilizing agents. This review presents a brief overview of pharmaceutical cocrystals regarding cocrystal design, obtainment methods, with particular focus on cocrystal solubility, and the solubility modulation by solution phase chemistry. |
id |
UFSP_43274fe936d1a6b3fefd45cd02c938d7 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br/:11600/56777 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Cocristais: uma estratégia promissora na área farmacêuticaCocrystals: a promising strategy in pharmaceutical sciencescocrystalsdrugsolubilitytransition pointthermodynamic stabilityPharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability. Aqueous cocrystal solubility can be orders of magnitude higher than that of the constituent drug and this solubility advantage can be fine-tuned based on environmental conditions such as pH and the presence of drug solubilizing agents. This review presents a brief overview of pharmaceutical cocrystals regarding cocrystal design, obtainment methods, with particular focus on cocrystal solubility, and the solubility modulation by solution phase chemistry.Univ Fed Santa Catarina, Dept Ciencias Farmaceut, BR-88040970 Florianopolis, SC, BrazilUniv Fed Sao Paulo, Inst Ciencias & Tecnol, BR-12231280 Sao Jose Dos Campos, SP, BrazilUniv Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USAUniv Cambridge, Dept Chem, Cambridge CB2 1EW, Cambs, EnglandMinist Educ, CAPES, BR-70040020 Brasilia, DF, BrazilInstituto de Ciências e Tecnologia, Universidade Federal de São Paulo, 12231-280 São José dos Campos – SP, BrasilWeb of ScienceSoc Brasileira Quimica2020-07-31T12:47:22Z2020-07-31T12:47:22Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1112-1125application/pdfhttp://dx.doi.org/10.21577/0100-4042.20160139Quimica Nova. Sao Paulo, v. 39, n. 9, p. 1112-1125, 2016.10.21577/0100-4042.20160139S0100-40422016000901112.pdf0100-4042S0100-40422016000901112https://repositorio.unifesp.br/handle/11600/56777WOS:000390207600012porQuimica NovaSao Pauloinfo:eu-repo/semantics/openAccessRocha, Alanny B. O.Kuminek, GislaineMachado, Tatiane C.Rosa, JulianaRauber, Gabriela S.Borba, Paola A. A.Siedler, SanaStulzer, Hellen K.Cuffini, Silvia Lucia [UNIFESP]Rodriguez-Hornedo, NairCardoso, Simone G.reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-11T14:44:04Zoai:repositorio.unifesp.br/:11600/56777Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-11T14:44:04Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Cocristais: uma estratégia promissora na área farmacêutica Cocrystals: a promising strategy in pharmaceutical sciences |
title |
Cocristais: uma estratégia promissora na área farmacêutica |
spellingShingle |
Cocristais: uma estratégia promissora na área farmacêutica Rocha, Alanny B. O. cocrystals drug solubility transition point thermodynamic stability |
title_short |
Cocristais: uma estratégia promissora na área farmacêutica |
title_full |
Cocristais: uma estratégia promissora na área farmacêutica |
title_fullStr |
Cocristais: uma estratégia promissora na área farmacêutica |
title_full_unstemmed |
Cocristais: uma estratégia promissora na área farmacêutica |
title_sort |
Cocristais: uma estratégia promissora na área farmacêutica |
author |
Rocha, Alanny B. O. |
author_facet |
Rocha, Alanny B. O. Kuminek, Gislaine Machado, Tatiane C. Rosa, Juliana Rauber, Gabriela S. Borba, Paola A. A. Siedler, Sana Stulzer, Hellen K. Cuffini, Silvia Lucia [UNIFESP] Rodriguez-Hornedo, Nair Cardoso, Simone G. |
author_role |
author |
author2 |
Kuminek, Gislaine Machado, Tatiane C. Rosa, Juliana Rauber, Gabriela S. Borba, Paola A. A. Siedler, Sana Stulzer, Hellen K. Cuffini, Silvia Lucia [UNIFESP] Rodriguez-Hornedo, Nair Cardoso, Simone G. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rocha, Alanny B. O. Kuminek, Gislaine Machado, Tatiane C. Rosa, Juliana Rauber, Gabriela S. Borba, Paola A. A. Siedler, Sana Stulzer, Hellen K. Cuffini, Silvia Lucia [UNIFESP] Rodriguez-Hornedo, Nair Cardoso, Simone G. |
dc.subject.por.fl_str_mv |
cocrystals drug solubility transition point thermodynamic stability |
topic |
cocrystals drug solubility transition point thermodynamic stability |
description |
Pharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability. Aqueous cocrystal solubility can be orders of magnitude higher than that of the constituent drug and this solubility advantage can be fine-tuned based on environmental conditions such as pH and the presence of drug solubilizing agents. This review presents a brief overview of pharmaceutical cocrystals regarding cocrystal design, obtainment methods, with particular focus on cocrystal solubility, and the solubility modulation by solution phase chemistry. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 2020-07-31T12:47:22Z 2020-07-31T12:47:22Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.21577/0100-4042.20160139 Quimica Nova. Sao Paulo, v. 39, n. 9, p. 1112-1125, 2016. 10.21577/0100-4042.20160139 S0100-40422016000901112.pdf 0100-4042 S0100-40422016000901112 https://repositorio.unifesp.br/handle/11600/56777 WOS:000390207600012 |
url |
http://dx.doi.org/10.21577/0100-4042.20160139 https://repositorio.unifesp.br/handle/11600/56777 |
identifier_str_mv |
Quimica Nova. Sao Paulo, v. 39, n. 9, p. 1112-1125, 2016. 10.21577/0100-4042.20160139 S0100-40422016000901112.pdf 0100-4042 S0100-40422016000901112 WOS:000390207600012 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Quimica Nova |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1112-1125 application/pdf |
dc.coverage.none.fl_str_mv |
Sao Paulo |
dc.publisher.none.fl_str_mv |
Soc Brasileira Quimica |
publisher.none.fl_str_mv |
Soc Brasileira Quimica |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268455296172032 |