The synthesis of a water-soluble derivative of rutin as an antiradical agent
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000800039 |
Resumo: | The purpose of this study was to synthesize a water-soluble derivative of rutin (compound 2) by introducing carboxylate groups on rutin's sugar moiety. The rutin derivative showed an almost 100-fold solubility increase in water. The antiradical capacity of compound 2 was evaluated using the luminol/AAPH system, and the derivative's activity was 1.5 times greater than that of Trolox®. Despite the derivative's high solubility in water (log P = -1.13), lipid peroxidation of brain homogenate membranes was very efficiently inhibited (inhibition values were only 19% lower than the inhibition values of rutin). |
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Química Nova (Online) |
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The synthesis of a water-soluble derivative of rutin as an antiradical agentwater-soluble derivative of rutinantiradical capacityantioxidant activityThe purpose of this study was to synthesize a water-soluble derivative of rutin (compound 2) by introducing carboxylate groups on rutin's sugar moiety. The rutin derivative showed an almost 100-fold solubility increase in water. The antiradical capacity of compound 2 was evaluated using the luminol/AAPH system, and the derivative's activity was 1.5 times greater than that of Trolox®. Despite the derivative's high solubility in water (log P = -1.13), lipid peroxidation of brain homogenate membranes was very efficiently inhibited (inhibition values were only 19% lower than the inhibition values of rutin).Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000800039Química Nova v.31 n.8 2008reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422008000800039info:eu-repo/semantics/openAccessPedriali,Carla AparecidaFernandes,Adjaci UchoaBernusso,Leandra de CássiaPolakiewicz,Bronislawpor2009-01-16T00:00:00Zoai:scielo:S0100-40422008000800039Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2009-01-16T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
The synthesis of a water-soluble derivative of rutin as an antiradical agent |
title |
The synthesis of a water-soluble derivative of rutin as an antiradical agent |
spellingShingle |
The synthesis of a water-soluble derivative of rutin as an antiradical agent Pedriali,Carla Aparecida water-soluble derivative of rutin antiradical capacity antioxidant activity |
title_short |
The synthesis of a water-soluble derivative of rutin as an antiradical agent |
title_full |
The synthesis of a water-soluble derivative of rutin as an antiradical agent |
title_fullStr |
The synthesis of a water-soluble derivative of rutin as an antiradical agent |
title_full_unstemmed |
The synthesis of a water-soluble derivative of rutin as an antiradical agent |
title_sort |
The synthesis of a water-soluble derivative of rutin as an antiradical agent |
author |
Pedriali,Carla Aparecida |
author_facet |
Pedriali,Carla Aparecida Fernandes,Adjaci Uchoa Bernusso,Leandra de Cássia Polakiewicz,Bronislaw |
author_role |
author |
author2 |
Fernandes,Adjaci Uchoa Bernusso,Leandra de Cássia Polakiewicz,Bronislaw |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Pedriali,Carla Aparecida Fernandes,Adjaci Uchoa Bernusso,Leandra de Cássia Polakiewicz,Bronislaw |
dc.subject.por.fl_str_mv |
water-soluble derivative of rutin antiradical capacity antioxidant activity |
topic |
water-soluble derivative of rutin antiradical capacity antioxidant activity |
description |
The purpose of this study was to synthesize a water-soluble derivative of rutin (compound 2) by introducing carboxylate groups on rutin's sugar moiety. The rutin derivative showed an almost 100-fold solubility increase in water. The antiradical capacity of compound 2 was evaluated using the luminol/AAPH system, and the derivative's activity was 1.5 times greater than that of Trolox®. Despite the derivative's high solubility in water (log P = -1.13), lipid peroxidation of brain homogenate membranes was very efficiently inhibited (inhibition values were only 19% lower than the inhibition values of rutin). |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000800039 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000800039 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
10.1590/S0100-40422008000800039 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.31 n.8 2008 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318108380233728 |