The synthesis of a water-soluble derivative of rutin as an antiradical agent

Detalhes bibliográficos
Autor(a) principal: Pedriali,Carla Aparecida
Data de Publicação: 2008
Outros Autores: Fernandes,Adjaci Uchoa, Bernusso,Leandra de Cássia, Polakiewicz,Bronislaw
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000800039
Resumo: The purpose of this study was to synthesize a water-soluble derivative of rutin (compound 2) by introducing carboxylate groups on rutin's sugar moiety. The rutin derivative showed an almost 100-fold solubility increase in water. The antiradical capacity of compound 2 was evaluated using the luminol/AAPH system, and the derivative's activity was 1.5 times greater than that of Trolox®. Despite the derivative's high solubility in water (log P = -1.13), lipid peroxidation of brain homogenate membranes was very efficiently inhibited (inhibition values were only 19% lower than the inhibition values of rutin).
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spelling The synthesis of a water-soluble derivative of rutin as an antiradical agentwater-soluble derivative of rutinantiradical capacityantioxidant activityThe purpose of this study was to synthesize a water-soluble derivative of rutin (compound 2) by introducing carboxylate groups on rutin's sugar moiety. The rutin derivative showed an almost 100-fold solubility increase in water. The antiradical capacity of compound 2 was evaluated using the luminol/AAPH system, and the derivative's activity was 1.5 times greater than that of Trolox®. Despite the derivative's high solubility in water (log P = -1.13), lipid peroxidation of brain homogenate membranes was very efficiently inhibited (inhibition values were only 19% lower than the inhibition values of rutin).Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000800039Química Nova v.31 n.8 2008reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422008000800039info:eu-repo/semantics/openAccessPedriali,Carla AparecidaFernandes,Adjaci UchoaBernusso,Leandra de CássiaPolakiewicz,Bronislawpor2009-01-16T00:00:00Zoai:scielo:S0100-40422008000800039Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2009-01-16T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv The synthesis of a water-soluble derivative of rutin as an antiradical agent
title The synthesis of a water-soluble derivative of rutin as an antiradical agent
spellingShingle The synthesis of a water-soluble derivative of rutin as an antiradical agent
Pedriali,Carla Aparecida
water-soluble derivative of rutin
antiradical capacity
antioxidant activity
title_short The synthesis of a water-soluble derivative of rutin as an antiradical agent
title_full The synthesis of a water-soluble derivative of rutin as an antiradical agent
title_fullStr The synthesis of a water-soluble derivative of rutin as an antiradical agent
title_full_unstemmed The synthesis of a water-soluble derivative of rutin as an antiradical agent
title_sort The synthesis of a water-soluble derivative of rutin as an antiradical agent
author Pedriali,Carla Aparecida
author_facet Pedriali,Carla Aparecida
Fernandes,Adjaci Uchoa
Bernusso,Leandra de Cássia
Polakiewicz,Bronislaw
author_role author
author2 Fernandes,Adjaci Uchoa
Bernusso,Leandra de Cássia
Polakiewicz,Bronislaw
author2_role author
author
author
dc.contributor.author.fl_str_mv Pedriali,Carla Aparecida
Fernandes,Adjaci Uchoa
Bernusso,Leandra de Cássia
Polakiewicz,Bronislaw
dc.subject.por.fl_str_mv water-soluble derivative of rutin
antiradical capacity
antioxidant activity
topic water-soluble derivative of rutin
antiradical capacity
antioxidant activity
description The purpose of this study was to synthesize a water-soluble derivative of rutin (compound 2) by introducing carboxylate groups on rutin's sugar moiety. The rutin derivative showed an almost 100-fold solubility increase in water. The antiradical capacity of compound 2 was evaluated using the luminol/AAPH system, and the derivative's activity was 1.5 times greater than that of Trolox®. Despite the derivative's high solubility in water (log P = -1.13), lipid peroxidation of brain homogenate membranes was very efficiently inhibited (inhibition values were only 19% lower than the inhibition values of rutin).
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000800039
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000800039
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422008000800039
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.31 n.8 2008
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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