Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC

Detalhes bibliográficos
Autor(a) principal: Bajerski,Lisiane
Data de Publicação: 2010
Outros Autores: Sangoi,Maximiliano da Silva, Barth,Thiago, Diefenbach,Isabel Fração, Dalmora,Sérgio Luís, Cardoso,Simone Gonçalves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000100021
Resumo: A capillary electrophoresis (CE) method was developed and validated for determination of cetirizine dihydrochloride in tablets and compounded capsules. The electrophoretic separation was performed in an uncoated fused-silica capillary (40 cm x 50 μm i.d.) using 20 mmol L-1 sodium tetraborate buffer (pH 9.3) as background electrolyte, a hydrodinamic sample injection at 50 mBar for 5 s, 20 KV applied voltage at 25 °C, and detection at 232 nm. The proposed method was compared with the high performance liquid chromatographic (HPLC) method previously validated for this drug, and statistical analysis showed no significant difference between the techniques.
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spelling Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLCcetirizinecapillary eletrophoresishigh performance liquid chromatographyA capillary electrophoresis (CE) method was developed and validated for determination of cetirizine dihydrochloride in tablets and compounded capsules. The electrophoretic separation was performed in an uncoated fused-silica capillary (40 cm x 50 μm i.d.) using 20 mmol L-1 sodium tetraborate buffer (pH 9.3) as background electrolyte, a hydrodinamic sample injection at 50 mBar for 5 s, 20 KV applied voltage at 25 °C, and detection at 232 nm. The proposed method was compared with the high performance liquid chromatographic (HPLC) method previously validated for this drug, and statistical analysis showed no significant difference between the techniques.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000100021Química Nova v.33 n.1 2010reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422010000100021info:eu-repo/semantics/openAccessBajerski,LisianeSangoi,Maximiliano da SilvaBarth,ThiagoDiefenbach,Isabel FraçãoDalmora,Sérgio LuísCardoso,Simone Gonçalveseng2010-02-05T00:00:00Zoai:scielo:S0100-40422010000100021Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2010-02-05T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC
title Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC
spellingShingle Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC
Bajerski,Lisiane
cetirizine
capillary eletrophoresis
high performance liquid chromatography
title_short Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC
title_full Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC
title_fullStr Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC
title_full_unstemmed Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC
title_sort Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC
author Bajerski,Lisiane
author_facet Bajerski,Lisiane
Sangoi,Maximiliano da Silva
Barth,Thiago
Diefenbach,Isabel Fração
Dalmora,Sérgio Luís
Cardoso,Simone Gonçalves
author_role author
author2 Sangoi,Maximiliano da Silva
Barth,Thiago
Diefenbach,Isabel Fração
Dalmora,Sérgio Luís
Cardoso,Simone Gonçalves
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bajerski,Lisiane
Sangoi,Maximiliano da Silva
Barth,Thiago
Diefenbach,Isabel Fração
Dalmora,Sérgio Luís
Cardoso,Simone Gonçalves
dc.subject.por.fl_str_mv cetirizine
capillary eletrophoresis
high performance liquid chromatography
topic cetirizine
capillary eletrophoresis
high performance liquid chromatography
description A capillary electrophoresis (CE) method was developed and validated for determination of cetirizine dihydrochloride in tablets and compounded capsules. The electrophoretic separation was performed in an uncoated fused-silica capillary (40 cm x 50 μm i.d.) using 20 mmol L-1 sodium tetraborate buffer (pH 9.3) as background electrolyte, a hydrodinamic sample injection at 50 mBar for 5 s, 20 KV applied voltage at 25 °C, and detection at 232 nm. The proposed method was compared with the high performance liquid chromatographic (HPLC) method previously validated for this drug, and statistical analysis showed no significant difference between the techniques.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000100021
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000100021
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422010000100021
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.33 n.1 2010
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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