Catalyzed and non-catalyzed synthesis of bioactive monastrol
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014001000022 |
Resumo: | The bioactive 3,4-dihydropyrimidin-2(1H)-thione derivative known as Monastrol was synthesized under catalyzed and non-catalyzed conditions through the Biginelli multicomponent reaction under solvent-free conditions. The use of two Lewis acids (FeCl3 and CuCl2) and two Brønsted acids (HCl and CF3COOH) as catalysts improved the reaction yields of the transformation compared with the non-catalyzed reaction. The experiments investigated catalysis and its role, the importance of multicomponent reactions and their green features, and the application of these concepts to the synthesis of a biologically important structure. |
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Catalyzed and non-catalyzed synthesis of bioactive monastrolMonastrolBiginellimulticomponent reactioncatalysisThe bioactive 3,4-dihydropyrimidin-2(1H)-thione derivative known as Monastrol was synthesized under catalyzed and non-catalyzed conditions through the Biginelli multicomponent reaction under solvent-free conditions. The use of two Lewis acids (FeCl3 and CuCl2) and two Brønsted acids (HCl and CF3COOH) as catalysts improved the reaction yields of the transformation compared with the non-catalyzed reaction. The experiments investigated catalysis and its role, the importance of multicomponent reactions and their green features, and the application of these concepts to the synthesis of a biologically important structure.Sociedade Brasileira de Química2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014001000022Química Nova v.37 n.10 2014reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0100-4042.20140266info:eu-repo/semantics/openAccessAlvim,Haline G. O.Correa,Jose R.Machado,Taynara R.Silva,Wender A.D. Neto,Brenno A.eng2014-11-28T00:00:00Zoai:scielo:S0100-40422014001000022Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2014-11-28T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Catalyzed and non-catalyzed synthesis of bioactive monastrol |
title |
Catalyzed and non-catalyzed synthesis of bioactive monastrol |
spellingShingle |
Catalyzed and non-catalyzed synthesis of bioactive monastrol Alvim,Haline G. O. Monastrol Biginelli multicomponent reaction catalysis |
title_short |
Catalyzed and non-catalyzed synthesis of bioactive monastrol |
title_full |
Catalyzed and non-catalyzed synthesis of bioactive monastrol |
title_fullStr |
Catalyzed and non-catalyzed synthesis of bioactive monastrol |
title_full_unstemmed |
Catalyzed and non-catalyzed synthesis of bioactive monastrol |
title_sort |
Catalyzed and non-catalyzed synthesis of bioactive monastrol |
author |
Alvim,Haline G. O. |
author_facet |
Alvim,Haline G. O. Correa,Jose R. Machado,Taynara R. Silva,Wender A. D. Neto,Brenno A. |
author_role |
author |
author2 |
Correa,Jose R. Machado,Taynara R. Silva,Wender A. D. Neto,Brenno A. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Alvim,Haline G. O. Correa,Jose R. Machado,Taynara R. Silva,Wender A. D. Neto,Brenno A. |
dc.subject.por.fl_str_mv |
Monastrol Biginelli multicomponent reaction catalysis |
topic |
Monastrol Biginelli multicomponent reaction catalysis |
description |
The bioactive 3,4-dihydropyrimidin-2(1H)-thione derivative known as Monastrol was synthesized under catalyzed and non-catalyzed conditions through the Biginelli multicomponent reaction under solvent-free conditions. The use of two Lewis acids (FeCl3 and CuCl2) and two Brønsted acids (HCl and CF3COOH) as catalysts improved the reaction yields of the transformation compared with the non-catalyzed reaction. The experiments investigated catalysis and its role, the importance of multicomponent reactions and their green features, and the application of these concepts to the synthesis of a biologically important structure. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014001000022 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014001000022 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0100-4042.20140266 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.37 n.10 2014 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318116326342656 |