DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith

Detalhes bibliográficos
Autor(a) principal: Sales,Kaio A.
Data de Publicação: 2020
Outros Autores: Pinheiro,Anderson A. V., Araújo,Diego I. A. F., Andrade,Rodrigo S. de, Agra,Maria de Fátima, Sobral,Marianna V., Magalhães,Hemerson I. F., Sousa,Valgrícia M. de, Braz-Filho,Raimundo, Silva,Marcelo S. da, Tavares,Josean F.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000600692
Resumo: A chemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith, a member of Annonaceae family, was carried out. The ethanolic extract from the roots of this plant led, by chromatography tecniches, to isolation of the new azaphenanthrene alkaloids dolichocarpine (1) and 9-methoxyeupolauramine (2), besides the known alkaloids eupolauramine (3), 3-methoxyeupolauridine (4), eupolauramine (5) and 4-methylsampangine (6). The structures of isolated compounds were established by 1D and 2D NMR, HRESIMS, tandem MSn and IR data. The cytotoxicity of compounds 1 - 5 was evaluated against HCT-116 (human colorectal carcinoma) and L929 (murine fibroblast) cell lines.
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spelling DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & SandwithAnnonaceaeAnaxagoreaalkaloidcytotoxicityA chemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith, a member of Annonaceae family, was carried out. The ethanolic extract from the roots of this plant led, by chromatography tecniches, to isolation of the new azaphenanthrene alkaloids dolichocarpine (1) and 9-methoxyeupolauramine (2), besides the known alkaloids eupolauramine (3), 3-methoxyeupolauridine (4), eupolauramine (5) and 4-methylsampangine (6). The structures of isolated compounds were established by 1D and 2D NMR, HRESIMS, tandem MSn and IR data. The cytotoxicity of compounds 1 - 5 was evaluated against HCT-116 (human colorectal carcinoma) and L929 (murine fibroblast) cell lines.Sociedade Brasileira de Química2020-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000600692Química Nova v.43 n.6 2020reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20170529info:eu-repo/semantics/openAccessSales,Kaio A.Pinheiro,Anderson A. V.Araújo,Diego I. A. F.Andrade,Rodrigo S. deAgra,Maria de FátimaSobral,Marianna V.Magalhães,Hemerson I. F.Sousa,Valgrícia M. deBraz-Filho,RaimundoSilva,Marcelo S. daTavares,Josean F.por2020-07-20T00:00:00Zoai:scielo:S0100-40422020000600692Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2020-07-20T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith
title DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith
spellingShingle DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith
Sales,Kaio A.
Annonaceae
Anaxagorea
alkaloid
cytotoxicity
title_short DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith
title_full DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith
title_fullStr DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith
title_full_unstemmed DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith
title_sort DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith
author Sales,Kaio A.
author_facet Sales,Kaio A.
Pinheiro,Anderson A. V.
Araújo,Diego I. A. F.
Andrade,Rodrigo S. de
Agra,Maria de Fátima
Sobral,Marianna V.
Magalhães,Hemerson I. F.
Sousa,Valgrícia M. de
Braz-Filho,Raimundo
Silva,Marcelo S. da
Tavares,Josean F.
author_role author
author2 Pinheiro,Anderson A. V.
Araújo,Diego I. A. F.
Andrade,Rodrigo S. de
Agra,Maria de Fátima
Sobral,Marianna V.
Magalhães,Hemerson I. F.
Sousa,Valgrícia M. de
Braz-Filho,Raimundo
Silva,Marcelo S. da
Tavares,Josean F.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sales,Kaio A.
Pinheiro,Anderson A. V.
Araújo,Diego I. A. F.
Andrade,Rodrigo S. de
Agra,Maria de Fátima
Sobral,Marianna V.
Magalhães,Hemerson I. F.
Sousa,Valgrícia M. de
Braz-Filho,Raimundo
Silva,Marcelo S. da
Tavares,Josean F.
dc.subject.por.fl_str_mv Annonaceae
Anaxagorea
alkaloid
cytotoxicity
topic Annonaceae
Anaxagorea
alkaloid
cytotoxicity
description A chemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith, a member of Annonaceae family, was carried out. The ethanolic extract from the roots of this plant led, by chromatography tecniches, to isolation of the new azaphenanthrene alkaloids dolichocarpine (1) and 9-methoxyeupolauramine (2), besides the known alkaloids eupolauramine (3), 3-methoxyeupolauridine (4), eupolauramine (5) and 4-methylsampangine (6). The structures of isolated compounds were established by 1D and 2D NMR, HRESIMS, tandem MSn and IR data. The cytotoxicity of compounds 1 - 5 was evaluated against HCT-116 (human colorectal carcinoma) and L929 (murine fibroblast) cell lines.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000600692
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000600692
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.21577/0100-4042.20170529
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.43 n.6 2020
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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