Alcalóides azafenantrenos isolados de Anaxagorea dolichocarpa Sprague & Sandwith (ANNONACEAE)

• Autor(a) principal: Lúcio, Ana Silvia Suassuna Carneiro
• Data de Publicação: 2011
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UFPB
• Texto Completo: https://repositorio.ufpb.br/jspui/handle/tede/6704
• topic: Annonaceae; Anaxagorea dolichocarpa; Alcalóides; Annonaceae; Anaxagorea dolichocarpa; Alkaloids; CIENCIAS BIOLOGICAS::FARMACOLOGIA

The Annonaceae family consists of approximately 135 genus and 2500 species distributed by tropical and subtropical regions of the world. In Brazil, the Annonaceae family comprises 26 genus, among these we find the genus Anaxagorea, with about 26 species distributed in Central America and South America. Among this species, Anaxagorea dolichocarpa Sprague & Sandwith is the Neotropical Annonaceae most common and well distributed. This work describes the results of phytochemical study of Anaxagorea dolichocarpa Sprague & Sandwith. The plant material was subjected to extraction processes, and partition chromatography for isolation of chemical constituents. The chemical structures was determined by spectroscopic methods, such as: Infrared, 1H and 13C Nuclear Magnetic Resonance, mass spectrometry and comparisons with literature. Of the hexane extract were isolated two alkaloids azaphenanthrenes: eupolauramine, described for the first time in the Annonaceae family and imbiline 1, described for the first time in the genus Anaxagorea. From the chloroform extract was isolated the alkaloid azaphenanthrene sampangine, described for the first time in the genus Anaxagorea. The results of this work contributed to the phytochemical study of Anaxagorea dolichocarpa Sprague & Sandwith to known chemotaxonomy of the genus Anaxagorea and the Annonaceae family.