Determinação de nimesulida por análise por injeção em fluxo com detecção amperométrica de múltiplos pulsos

• Autor(a) principal: Lima,Amanda Barbosa
• Data de Publicação: 2013
• Outros Autores: Chaves,Sandro Cruz, Silva,Leonardo Morais da, Pereira,Polyana Fernandes, Richter,Eduardo Mathias, Santos,Wallans Torres Pio dos
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Química Nova (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000900004
• topic: pulse amperometric detection; nimesulide; boron-doped diamond

A simple and fast method for the determination of nimesulide (NI) using flow injection analysis with multiple-pulse amperometric (FIA-MPA) detection at a boron-doped diamond (BDD) electrode was developed. The method was based mainly on the application of a four-potential waveform, E1(det) = -0.8 V / 30 ms, E2(det) = 0.6 V / 30 ms, E3(det) = -0.4 V / 30 ms and E4(cleaning) = -0.45 V / 300 ms versus Ag/AgCl (3.0 mol L-1 KCl). NI was detected at three different electrode potentials, at which the nitro group undergoes different redox reactions. The proposed method was selective and sensitive (detection limit of 81.0 nmol L-1), and successfully applied for the determination of NI in pharmaceutical formulations, yielding similar results to those obtained by the reference method.