NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES

Detalhes bibliográficos
Autor(a) principal: Qarah,Nagib A. S.
Data de Publicação: 2020
Outros Autores: Abdulrahman,Sameer A. M., Algethami,Faisal K., Basavaiah,Kanakapura, El-Maaiden,Ezzouhra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000100044
Resumo: Three simple methods are described for the determination of amoxicillin (AMX) in bulk drug and dosage forms using iodate-iodide mixture reagent. These methods employed the well-known analytical reaction between iodate-iodide mixture in the presence of acid solution. The iodide oxidized by iodate to iodine in an amount equivalent to the -COOH group present in amoxicillin (AMX) and the liberated iodine determined by titrimetry and spectrophotometry. In the titrimetric method (method A), the liberated iodine was reacted with a measured excess of thiosulphate and the residual thiosulphate was determined by titration with a standard iodine solution using starch indicator, the method was applicable over 2 - 16 mg of AMX. In the second and third methods, the absorbance of the liberated iodine was measured at 370 nm (method B) and also iodine was reacted with starch and starch-iodine complex was measured at 570 nm (method C). In spectrophotometric methods (B and C), Beer’s law was obeyed over the concentration range of 5 - 50 and 5 - 60 µg mL-1 AMX with a molar absorptivity values of 5.55×103 L mol-1 cm-1 and 4.76×103 L mol-1 cm-1 for the method A and method B, respectively. The limits of detection (LOD) and quantification (LOQ) were calculated for method B and method C. The proposed methods were found to yield reliable results when applied to bulk drug and dosage forms analysis, and hence they can be applied in quality control laboratories.
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spelling NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIESamoxicillinassaytitrimetryspectrophotometryiodateThree simple methods are described for the determination of amoxicillin (AMX) in bulk drug and dosage forms using iodate-iodide mixture reagent. These methods employed the well-known analytical reaction between iodate-iodide mixture in the presence of acid solution. The iodide oxidized by iodate to iodine in an amount equivalent to the -COOH group present in amoxicillin (AMX) and the liberated iodine determined by titrimetry and spectrophotometry. In the titrimetric method (method A), the liberated iodine was reacted with a measured excess of thiosulphate and the residual thiosulphate was determined by titration with a standard iodine solution using starch indicator, the method was applicable over 2 - 16 mg of AMX. In the second and third methods, the absorbance of the liberated iodine was measured at 370 nm (method B) and also iodine was reacted with starch and starch-iodine complex was measured at 570 nm (method C). In spectrophotometric methods (B and C), Beer’s law was obeyed over the concentration range of 5 - 50 and 5 - 60 µg mL-1 AMX with a molar absorptivity values of 5.55×103 L mol-1 cm-1 and 4.76×103 L mol-1 cm-1 for the method A and method B, respectively. The limits of detection (LOD) and quantification (LOQ) were calculated for method B and method C. The proposed methods were found to yield reliable results when applied to bulk drug and dosage forms analysis, and hence they can be applied in quality control laboratories.Sociedade Brasileira de Química2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000100044Química Nova v.43 n.1 2020reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20170455info:eu-repo/semantics/openAccessQarah,Nagib A. S.Abdulrahman,Sameer A. M.Algethami,Faisal K.Basavaiah,KanakapuraEl-Maaiden,Ezzouhraeng2020-06-05T00:00:00Zoai:scielo:S0100-40422020000100044Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2020-06-05T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES
title NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES
spellingShingle NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES
Qarah,Nagib A. S.
amoxicillin
assay
titrimetry
spectrophotometry
iodate
title_short NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES
title_full NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES
title_fullStr NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES
title_full_unstemmed NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES
title_sort NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES
author Qarah,Nagib A. S.
author_facet Qarah,Nagib A. S.
Abdulrahman,Sameer A. M.
Algethami,Faisal K.
Basavaiah,Kanakapura
El-Maaiden,Ezzouhra
author_role author
author2 Abdulrahman,Sameer A. M.
Algethami,Faisal K.
Basavaiah,Kanakapura
El-Maaiden,Ezzouhra
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Qarah,Nagib A. S.
Abdulrahman,Sameer A. M.
Algethami,Faisal K.
Basavaiah,Kanakapura
El-Maaiden,Ezzouhra
dc.subject.por.fl_str_mv amoxicillin
assay
titrimetry
spectrophotometry
iodate
topic amoxicillin
assay
titrimetry
spectrophotometry
iodate
description Three simple methods are described for the determination of amoxicillin (AMX) in bulk drug and dosage forms using iodate-iodide mixture reagent. These methods employed the well-known analytical reaction between iodate-iodide mixture in the presence of acid solution. The iodide oxidized by iodate to iodine in an amount equivalent to the -COOH group present in amoxicillin (AMX) and the liberated iodine determined by titrimetry and spectrophotometry. In the titrimetric method (method A), the liberated iodine was reacted with a measured excess of thiosulphate and the residual thiosulphate was determined by titration with a standard iodine solution using starch indicator, the method was applicable over 2 - 16 mg of AMX. In the second and third methods, the absorbance of the liberated iodine was measured at 370 nm (method B) and also iodine was reacted with starch and starch-iodine complex was measured at 570 nm (method C). In spectrophotometric methods (B and C), Beer’s law was obeyed over the concentration range of 5 - 50 and 5 - 60 µg mL-1 AMX with a molar absorptivity values of 5.55×103 L mol-1 cm-1 and 4.76×103 L mol-1 cm-1 for the method A and method B, respectively. The limits of detection (LOD) and quantification (LOQ) were calculated for method B and method C. The proposed methods were found to yield reliable results when applied to bulk drug and dosage forms analysis, and hence they can be applied in quality control laboratories.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000100044
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000100044
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.21577/0100-4042.20170455
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.43 n.1 2020
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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