NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000100044 |
Resumo: | Three simple methods are described for the determination of amoxicillin (AMX) in bulk drug and dosage forms using iodate-iodide mixture reagent. These methods employed the well-known analytical reaction between iodate-iodide mixture in the presence of acid solution. The iodide oxidized by iodate to iodine in an amount equivalent to the -COOH group present in amoxicillin (AMX) and the liberated iodine determined by titrimetry and spectrophotometry. In the titrimetric method (method A), the liberated iodine was reacted with a measured excess of thiosulphate and the residual thiosulphate was determined by titration with a standard iodine solution using starch indicator, the method was applicable over 2 - 16 mg of AMX. In the second and third methods, the absorbance of the liberated iodine was measured at 370 nm (method B) and also iodine was reacted with starch and starch-iodine complex was measured at 570 nm (method C). In spectrophotometric methods (B and C), Beer’s law was obeyed over the concentration range of 5 - 50 and 5 - 60 µg mL-1 AMX with a molar absorptivity values of 5.55×103 L mol-1 cm-1 and 4.76×103 L mol-1 cm-1 for the method A and method B, respectively. The limits of detection (LOD) and quantification (LOQ) were calculated for method B and method C. The proposed methods were found to yield reliable results when applied to bulk drug and dosage forms analysis, and hence they can be applied in quality control laboratories. |
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NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIESamoxicillinassaytitrimetryspectrophotometryiodateThree simple methods are described for the determination of amoxicillin (AMX) in bulk drug and dosage forms using iodate-iodide mixture reagent. These methods employed the well-known analytical reaction between iodate-iodide mixture in the presence of acid solution. The iodide oxidized by iodate to iodine in an amount equivalent to the -COOH group present in amoxicillin (AMX) and the liberated iodine determined by titrimetry and spectrophotometry. In the titrimetric method (method A), the liberated iodine was reacted with a measured excess of thiosulphate and the residual thiosulphate was determined by titration with a standard iodine solution using starch indicator, the method was applicable over 2 - 16 mg of AMX. In the second and third methods, the absorbance of the liberated iodine was measured at 370 nm (method B) and also iodine was reacted with starch and starch-iodine complex was measured at 570 nm (method C). In spectrophotometric methods (B and C), Beer’s law was obeyed over the concentration range of 5 - 50 and 5 - 60 µg mL-1 AMX with a molar absorptivity values of 5.55×103 L mol-1 cm-1 and 4.76×103 L mol-1 cm-1 for the method A and method B, respectively. The limits of detection (LOD) and quantification (LOQ) were calculated for method B and method C. The proposed methods were found to yield reliable results when applied to bulk drug and dosage forms analysis, and hence they can be applied in quality control laboratories.Sociedade Brasileira de Química2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000100044Química Nova v.43 n.1 2020reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20170455info:eu-repo/semantics/openAccessQarah,Nagib A. S.Abdulrahman,Sameer A. M.Algethami,Faisal K.Basavaiah,KanakapuraEl-Maaiden,Ezzouhraeng2020-06-05T00:00:00Zoai:scielo:S0100-40422020000100044Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2020-06-05T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES |
title |
NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES |
spellingShingle |
NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES Qarah,Nagib A. S. amoxicillin assay titrimetry spectrophotometry iodate |
title_short |
NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES |
title_full |
NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES |
title_fullStr |
NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES |
title_full_unstemmed |
NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES |
title_sort |
NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES |
author |
Qarah,Nagib A. S. |
author_facet |
Qarah,Nagib A. S. Abdulrahman,Sameer A. M. Algethami,Faisal K. Basavaiah,Kanakapura El-Maaiden,Ezzouhra |
author_role |
author |
author2 |
Abdulrahman,Sameer A. M. Algethami,Faisal K. Basavaiah,Kanakapura El-Maaiden,Ezzouhra |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Qarah,Nagib A. S. Abdulrahman,Sameer A. M. Algethami,Faisal K. Basavaiah,Kanakapura El-Maaiden,Ezzouhra |
dc.subject.por.fl_str_mv |
amoxicillin assay titrimetry spectrophotometry iodate |
topic |
amoxicillin assay titrimetry spectrophotometry iodate |
description |
Three simple methods are described for the determination of amoxicillin (AMX) in bulk drug and dosage forms using iodate-iodide mixture reagent. These methods employed the well-known analytical reaction between iodate-iodide mixture in the presence of acid solution. The iodide oxidized by iodate to iodine in an amount equivalent to the -COOH group present in amoxicillin (AMX) and the liberated iodine determined by titrimetry and spectrophotometry. In the titrimetric method (method A), the liberated iodine was reacted with a measured excess of thiosulphate and the residual thiosulphate was determined by titration with a standard iodine solution using starch indicator, the method was applicable over 2 - 16 mg of AMX. In the second and third methods, the absorbance of the liberated iodine was measured at 370 nm (method B) and also iodine was reacted with starch and starch-iodine complex was measured at 570 nm (method C). In spectrophotometric methods (B and C), Beer’s law was obeyed over the concentration range of 5 - 50 and 5 - 60 µg mL-1 AMX with a molar absorptivity values of 5.55×103 L mol-1 cm-1 and 4.76×103 L mol-1 cm-1 for the method A and method B, respectively. The limits of detection (LOD) and quantification (LOQ) were calculated for method B and method C. The proposed methods were found to yield reliable results when applied to bulk drug and dosage forms analysis, and hence they can be applied in quality control laboratories. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000100044 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000100044 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0100-4042.20170455 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.43 n.1 2020 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318120089681920 |