Estratégias farmacológicas para a terapia anti-AIDS

Detalhes bibliográficos
Autor(a) principal: Peçanha,Emerson Poley
Data de Publicação: 2002
Outros Autores: Antunes,Octavio A. C., Tanuri,Amilcar
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000700012
Resumo: The replicative cycle of HIV presents several events. The proteins involved in these events can be anticipated as pharmacological targets, aiming to the development of anti viral agents. Presently, there are fifteen commercially available anti-HIV drugs, which act at substrate binding site of reverse transcriptase (zidovudine, didanosine, zalcitabine, stavudine, lamivudine and abacavir), at a non-substrate binding site of reverse transcriptase (nevirapine, delavirdine and efavirenz), or by inhibiting HIV protease activity (saquinavir, ritonavir, indinavir, nelfinavir, amprenavir and lopinavir). The present review focus both on these established classes of drugs and on new classes of compounds acting on other virus specific steps.
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spelling Estratégias farmacológicas para a terapia anti-AIDSHIV life cycleAIDS therapyperspectives in AIDS therapyThe replicative cycle of HIV presents several events. The proteins involved in these events can be anticipated as pharmacological targets, aiming to the development of anti viral agents. Presently, there are fifteen commercially available anti-HIV drugs, which act at substrate binding site of reverse transcriptase (zidovudine, didanosine, zalcitabine, stavudine, lamivudine and abacavir), at a non-substrate binding site of reverse transcriptase (nevirapine, delavirdine and efavirenz), or by inhibiting HIV protease activity (saquinavir, ritonavir, indinavir, nelfinavir, amprenavir and lopinavir). The present review focus both on these established classes of drugs and on new classes of compounds acting on other virus specific steps.Sociedade Brasileira de Química2002-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000700012Química Nova v.25 n.6b 2002reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422002000700012info:eu-repo/semantics/openAccessPeçanha,Emerson PoleyAntunes,Octavio A. C.Tanuri,Amilcarpor2002-12-12T00:00:00Zoai:scielo:S0100-40422002000700012Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2002-12-12T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Estratégias farmacológicas para a terapia anti-AIDS
title Estratégias farmacológicas para a terapia anti-AIDS
spellingShingle Estratégias farmacológicas para a terapia anti-AIDS
Peçanha,Emerson Poley
HIV life cycle
AIDS therapy
perspectives in AIDS therapy
title_short Estratégias farmacológicas para a terapia anti-AIDS
title_full Estratégias farmacológicas para a terapia anti-AIDS
title_fullStr Estratégias farmacológicas para a terapia anti-AIDS
title_full_unstemmed Estratégias farmacológicas para a terapia anti-AIDS
title_sort Estratégias farmacológicas para a terapia anti-AIDS
author Peçanha,Emerson Poley
author_facet Peçanha,Emerson Poley
Antunes,Octavio A. C.
Tanuri,Amilcar
author_role author
author2 Antunes,Octavio A. C.
Tanuri,Amilcar
author2_role author
author
dc.contributor.author.fl_str_mv Peçanha,Emerson Poley
Antunes,Octavio A. C.
Tanuri,Amilcar
dc.subject.por.fl_str_mv HIV life cycle
AIDS therapy
perspectives in AIDS therapy
topic HIV life cycle
AIDS therapy
perspectives in AIDS therapy
description The replicative cycle of HIV presents several events. The proteins involved in these events can be anticipated as pharmacological targets, aiming to the development of anti viral agents. Presently, there are fifteen commercially available anti-HIV drugs, which act at substrate binding site of reverse transcriptase (zidovudine, didanosine, zalcitabine, stavudine, lamivudine and abacavir), at a non-substrate binding site of reverse transcriptase (nevirapine, delavirdine and efavirenz), or by inhibiting HIV protease activity (saquinavir, ritonavir, indinavir, nelfinavir, amprenavir and lopinavir). The present review focus both on these established classes of drugs and on new classes of compounds acting on other virus specific steps.
publishDate 2002
dc.date.none.fl_str_mv 2002-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000700012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000700012
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422002000700012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.25 n.6b 2002
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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