Aplysfistularine: a novel dibromotyrosine derivative isolated from Aplysina fistularis

• Autor(a) principal: Lira,Narlize Silva
• Data de Publicação: 2012
• Outros Autores: Monte-Neto,Rubens L., Marchi,João Guilherme B., Lins,Antônio Cláudio da Silva, Tavares,Josean Fechine, Silva,Marcelo Sobral da, Dias,Celidarque da Silva, Barbosa-Filho,José Maria, Santos,Creusioni Figueredo dos, Cunha,Emídio Vasconcelos Leitão da, Pinheiro,Ulisses dos Santos, Braz-Filho,Raimundo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Química Nova (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100017
• topic: Aplysina fistularis; aplysfistularine; topoisomerase activity

The new dibromotyrosine derivative 3,5-dibromo-4-[3'dimethylamonium]propoxyphenyl]-N,N,N-trimethylethanamonium, here referred to as aplysfistularine (1), was isolated from the marine sponge Aplysina fistularis along with 2-(3,5-dibromo-4methoxyphenyl)-N,N,N-trimethylethanamonium (2), aplysterol (3) and 24,28-didehydroaplysterol (4). Their identification was performed by mass spectrometry, infrared, ¹H and 13C NMR, and by comparison with literature data. Compound 2 and the mixture of 3 and 4 were tested in vitro (inhibitory activity) with supercoiled DNA relaxation techniques, and showed inhibitory activity on human DNA topoisomerase II-α. Compound 1 was not tested due to paucity of the material.