Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations

Detalhes bibliográficos
Autor(a) principal: Rahman,Nafisur
Data de Publicação: 2012
Outros Autores: Khatoon,Asma, Rahman,Habibur
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000200028
Resumo: A spectrophotometric method based on the formation of ion-pair complex between haloperidol and eriochrome black T (EBT) at pH 1.85 has been described. The formed complex was extracted quantitatively into chloroform and measured at 510 nm. Infra red (IR) studies were performed to confirm the formation of ion-pair complex. Beer's law was obeyed in the concentration range of 2.0-9.0 µg mL-1 with molar absorptivity of 2.67 × 10(4) L mol-1 cm-1. The detection limit was found to be 0.18 µg mL-1. Statistical comparison of the results of the proposed method with those of the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.
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spelling Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparationshaloperidolion-pair complexspectrophotometryA spectrophotometric method based on the formation of ion-pair complex between haloperidol and eriochrome black T (EBT) at pH 1.85 has been described. The formed complex was extracted quantitatively into chloroform and measured at 510 nm. Infra red (IR) studies were performed to confirm the formation of ion-pair complex. Beer's law was obeyed in the concentration range of 2.0-9.0 µg mL-1 with molar absorptivity of 2.67 × 10(4) L mol-1 cm-1. The detection limit was found to be 0.18 µg mL-1. Statistical comparison of the results of the proposed method with those of the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000200028Química Nova v.35 n.2 2012reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422012000200028info:eu-repo/semantics/openAccessRahman,NafisurKhatoon,AsmaRahman,Habibureng2012-04-03T00:00:00Zoai:scielo:S0100-40422012000200028Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2012-04-03T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations
title Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations
spellingShingle Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations
Rahman,Nafisur
haloperidol
ion-pair complex
spectrophotometry
title_short Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations
title_full Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations
title_fullStr Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations
title_full_unstemmed Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations
title_sort Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations
author Rahman,Nafisur
author_facet Rahman,Nafisur
Khatoon,Asma
Rahman,Habibur
author_role author
author2 Khatoon,Asma
Rahman,Habibur
author2_role author
author
dc.contributor.author.fl_str_mv Rahman,Nafisur
Khatoon,Asma
Rahman,Habibur
dc.subject.por.fl_str_mv haloperidol
ion-pair complex
spectrophotometry
topic haloperidol
ion-pair complex
spectrophotometry
description A spectrophotometric method based on the formation of ion-pair complex between haloperidol and eriochrome black T (EBT) at pH 1.85 has been described. The formed complex was extracted quantitatively into chloroform and measured at 510 nm. Infra red (IR) studies were performed to confirm the formation of ion-pair complex. Beer's law was obeyed in the concentration range of 2.0-9.0 µg mL-1 with molar absorptivity of 2.67 × 10(4) L mol-1 cm-1. The detection limit was found to be 0.18 µg mL-1. Statistical comparison of the results of the proposed method with those of the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000200028
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000200028
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422012000200028
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.35 n.2 2012
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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