Reaction mixtures formed by nitrite and selected sulfa-drugs showed mutagenicity in acidic medium

Detalhes bibliográficos
Autor(a) principal: Trossero,Claudia
Data de Publicação: 2009
Outros Autores: Pontoriero,Ana, Hure,Estela, Monti,Laura, Gorr,Carolina, Mosconi,Natalia, Rizzotto,Marcela, Caffarena,Graciela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500013
Resumo: Nitrite, which is present in preserved meat and can be produced in the oral cavity by reduction of nitrate taken from vegetables, could react in stomach with nitrosatable drugs, giving genotoxic-carcinogenic N-nitroso compounds (NOC). The mutagenicity of reaction mixtures formed by sodium nitrite and selected sulfa-drugs (sulfathiazole, HST; phtalylsulfathiazole, PhST; complex Co(II)-sulfathiazole, Co(II)-ST) in acidic medium was evaluated using the Salmonella typhimurium reverse mutation assay (Ames test), with TA98 and TA 100 strains. The reactions were carried out at room temperature, with a mole ratio [nitrite]/[sulfa-drug] > 1. The three reaction mixtures showed mutagenic effects in the considered range.
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spelling Reaction mixtures formed by nitrite and selected sulfa-drugs showed mutagenicity in acidic mediumnitritesulfa-drugsmutagenicityNitrite, which is present in preserved meat and can be produced in the oral cavity by reduction of nitrate taken from vegetables, could react in stomach with nitrosatable drugs, giving genotoxic-carcinogenic N-nitroso compounds (NOC). The mutagenicity of reaction mixtures formed by sodium nitrite and selected sulfa-drugs (sulfathiazole, HST; phtalylsulfathiazole, PhST; complex Co(II)-sulfathiazole, Co(II)-ST) in acidic medium was evaluated using the Salmonella typhimurium reverse mutation assay (Ames test), with TA98 and TA 100 strains. The reactions were carried out at room temperature, with a mole ratio [nitrite]/[sulfa-drug] > 1. The three reaction mixtures showed mutagenic effects in the considered range.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500013Química Nova v.32 n.5 2009reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422009000500013info:eu-repo/semantics/openAccessTrossero,ClaudiaPontoriero,AnaHure,EstelaMonti,LauraGorr,CarolinaMosconi,NataliaRizzotto,MarcelaCaffarena,Gracielaeng2009-07-30T00:00:00Zoai:scielo:S0100-40422009000500013Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2009-07-30T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Reaction mixtures formed by nitrite and selected sulfa-drugs showed mutagenicity in acidic medium
title Reaction mixtures formed by nitrite and selected sulfa-drugs showed mutagenicity in acidic medium
spellingShingle Reaction mixtures formed by nitrite and selected sulfa-drugs showed mutagenicity in acidic medium
Trossero,Claudia
nitrite
sulfa-drugs
mutagenicity
title_short Reaction mixtures formed by nitrite and selected sulfa-drugs showed mutagenicity in acidic medium
title_full Reaction mixtures formed by nitrite and selected sulfa-drugs showed mutagenicity in acidic medium
title_fullStr Reaction mixtures formed by nitrite and selected sulfa-drugs showed mutagenicity in acidic medium
title_full_unstemmed Reaction mixtures formed by nitrite and selected sulfa-drugs showed mutagenicity in acidic medium
title_sort Reaction mixtures formed by nitrite and selected sulfa-drugs showed mutagenicity in acidic medium
author Trossero,Claudia
author_facet Trossero,Claudia
Pontoriero,Ana
Hure,Estela
Monti,Laura
Gorr,Carolina
Mosconi,Natalia
Rizzotto,Marcela
Caffarena,Graciela
author_role author
author2 Pontoriero,Ana
Hure,Estela
Monti,Laura
Gorr,Carolina
Mosconi,Natalia
Rizzotto,Marcela
Caffarena,Graciela
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Trossero,Claudia
Pontoriero,Ana
Hure,Estela
Monti,Laura
Gorr,Carolina
Mosconi,Natalia
Rizzotto,Marcela
Caffarena,Graciela
dc.subject.por.fl_str_mv nitrite
sulfa-drugs
mutagenicity
topic nitrite
sulfa-drugs
mutagenicity
description Nitrite, which is present in preserved meat and can be produced in the oral cavity by reduction of nitrate taken from vegetables, could react in stomach with nitrosatable drugs, giving genotoxic-carcinogenic N-nitroso compounds (NOC). The mutagenicity of reaction mixtures formed by sodium nitrite and selected sulfa-drugs (sulfathiazole, HST; phtalylsulfathiazole, PhST; complex Co(II)-sulfathiazole, Co(II)-ST) in acidic medium was evaluated using the Salmonella typhimurium reverse mutation assay (Ames test), with TA98 and TA 100 strains. The reactions were carried out at room temperature, with a mole ratio [nitrite]/[sulfa-drug] > 1. The three reaction mixtures showed mutagenic effects in the considered range.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422009000500013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.32 n.5 2009
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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