Alendronato de sódio: metodologias para análise quantitativa

Detalhes bibliográficos
Autor(a) principal: Ribeiro,Ana Ferreira
Data de Publicação: 2005
Outros Autores: Volpato,Nadia Maria
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000500024
Resumo: This paper presents a review of some published proposals for the analysis of sodium alendronate. The drug is an aminobisphosphonate compound used to inhibit the osteoclastic resorption of bone, and different methods were developed for its quantitative determination. These methodologies employed reversed-phase or ion-exchange HPLC analysis, both associated with different detectors: UV and fluorescence detection after derivatization of the drug, conductivity and refractive index detectors, as well as the indirect UV detection. Titrimetry and spectrophotometry (with previous complexation of the drug), which are simpler procedures, were also described, but they showed poor specificity when compared to liquid chromatography.
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spelling Alendronato de sódio: metodologias para análise quantitativasodium alendronateHPLC analysisderivatizationThis paper presents a review of some published proposals for the analysis of sodium alendronate. The drug is an aminobisphosphonate compound used to inhibit the osteoclastic resorption of bone, and different methods were developed for its quantitative determination. These methodologies employed reversed-phase or ion-exchange HPLC analysis, both associated with different detectors: UV and fluorescence detection after derivatization of the drug, conductivity and refractive index detectors, as well as the indirect UV detection. Titrimetry and spectrophotometry (with previous complexation of the drug), which are simpler procedures, were also described, but they showed poor specificity when compared to liquid chromatography.Sociedade Brasileira de Química2005-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000500024Química Nova v.28 n.5 2005reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422005000500024info:eu-repo/semantics/openAccessRibeiro,Ana FerreiraVolpato,Nadia Mariapor2005-09-23T00:00:00Zoai:scielo:S0100-40422005000500024Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2005-09-23T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Alendronato de sódio: metodologias para análise quantitativa
title Alendronato de sódio: metodologias para análise quantitativa
spellingShingle Alendronato de sódio: metodologias para análise quantitativa
Ribeiro,Ana Ferreira
sodium alendronate
HPLC analysis
derivatization
title_short Alendronato de sódio: metodologias para análise quantitativa
title_full Alendronato de sódio: metodologias para análise quantitativa
title_fullStr Alendronato de sódio: metodologias para análise quantitativa
title_full_unstemmed Alendronato de sódio: metodologias para análise quantitativa
title_sort Alendronato de sódio: metodologias para análise quantitativa
author Ribeiro,Ana Ferreira
author_facet Ribeiro,Ana Ferreira
Volpato,Nadia Maria
author_role author
author2 Volpato,Nadia Maria
author2_role author
dc.contributor.author.fl_str_mv Ribeiro,Ana Ferreira
Volpato,Nadia Maria
dc.subject.por.fl_str_mv sodium alendronate
HPLC analysis
derivatization
topic sodium alendronate
HPLC analysis
derivatization
description This paper presents a review of some published proposals for the analysis of sodium alendronate. The drug is an aminobisphosphonate compound used to inhibit the osteoclastic resorption of bone, and different methods were developed for its quantitative determination. These methodologies employed reversed-phase or ion-exchange HPLC analysis, both associated with different detectors: UV and fluorescence detection after derivatization of the drug, conductivity and refractive index detectors, as well as the indirect UV detection. Titrimetry and spectrophotometry (with previous complexation of the drug), which are simpler procedures, were also described, but they showed poor specificity when compared to liquid chromatography.
publishDate 2005
dc.date.none.fl_str_mv 2005-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000500024
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000500024
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422005000500024
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.28 n.5 2005
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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