High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles

Detalhes bibliográficos
Autor(a) principal: Cruz,Letícia
Data de Publicação: 2009
Outros Autores: Assumpção,Evelise, Guterres,Sílvia Stanisçuaski, Pohlmann,Adriana Raffin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500016
Resumo: The hydrophilic drug sodium alendronate was encapsulated in blended microparticles of Eudragit® S100 and Methocel® F4M or Methocel® K100LV. Both formulations prepared by spray-drying showed spherical collapsed shape and smooth surface, encapsulation efficiencies of 85 and 82% and mean diameters of 11.7 and 8.4 µm, respectively. At pH 1.2, in vitro dissolution studies showed good gastro-resistance for both formulations. At pH 6.8, the sodium alendronate release from the microparticles was delayed and was controlled by Fickian diffusion. In conclusion, the prepared microparticles showed high encapsulation efficiency of sodium alendronate presenting gastro-resistance and sustained release suitable for its oral administration.
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spelling High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticleshydrophilic drugsodium alendronatemicroparticlesThe hydrophilic drug sodium alendronate was encapsulated in blended microparticles of Eudragit® S100 and Methocel® F4M or Methocel® K100LV. Both formulations prepared by spray-drying showed spherical collapsed shape and smooth surface, encapsulation efficiencies of 85 and 82% and mean diameters of 11.7 and 8.4 µm, respectively. At pH 1.2, in vitro dissolution studies showed good gastro-resistance for both formulations. At pH 6.8, the sodium alendronate release from the microparticles was delayed and was controlled by Fickian diffusion. In conclusion, the prepared microparticles showed high encapsulation efficiency of sodium alendronate presenting gastro-resistance and sustained release suitable for its oral administration.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500016Química Nova v.32 n.5 2009reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422009000500016info:eu-repo/semantics/openAccessCruz,LetíciaAssumpção,EveliseGuterres,Sílvia StanisçuaskiPohlmann,Adriana Raffineng2009-07-30T00:00:00Zoai:scielo:S0100-40422009000500016Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2009-07-30T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles
title High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles
spellingShingle High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles
Cruz,Letícia
hydrophilic drug
sodium alendronate
microparticles
title_short High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles
title_full High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles
title_fullStr High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles
title_full_unstemmed High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles
title_sort High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles
author Cruz,Letícia
author_facet Cruz,Letícia
Assumpção,Evelise
Guterres,Sílvia Stanisçuaski
Pohlmann,Adriana Raffin
author_role author
author2 Assumpção,Evelise
Guterres,Sílvia Stanisçuaski
Pohlmann,Adriana Raffin
author2_role author
author
author
dc.contributor.author.fl_str_mv Cruz,Letícia
Assumpção,Evelise
Guterres,Sílvia Stanisçuaski
Pohlmann,Adriana Raffin
dc.subject.por.fl_str_mv hydrophilic drug
sodium alendronate
microparticles
topic hydrophilic drug
sodium alendronate
microparticles
description The hydrophilic drug sodium alendronate was encapsulated in blended microparticles of Eudragit® S100 and Methocel® F4M or Methocel® K100LV. Both formulations prepared by spray-drying showed spherical collapsed shape and smooth surface, encapsulation efficiencies of 85 and 82% and mean diameters of 11.7 and 8.4 µm, respectively. At pH 1.2, in vitro dissolution studies showed good gastro-resistance for both formulations. At pH 6.8, the sodium alendronate release from the microparticles was delayed and was controlled by Fickian diffusion. In conclusion, the prepared microparticles showed high encapsulation efficiency of sodium alendronate presenting gastro-resistance and sustained release suitable for its oral administration.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422009000500016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.32 n.5 2009
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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