High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500016 |
Resumo: | The hydrophilic drug sodium alendronate was encapsulated in blended microparticles of Eudragit® S100 and Methocel® F4M or Methocel® K100LV. Both formulations prepared by spray-drying showed spherical collapsed shape and smooth surface, encapsulation efficiencies of 85 and 82% and mean diameters of 11.7 and 8.4 µm, respectively. At pH 1.2, in vitro dissolution studies showed good gastro-resistance for both formulations. At pH 6.8, the sodium alendronate release from the microparticles was delayed and was controlled by Fickian diffusion. In conclusion, the prepared microparticles showed high encapsulation efficiency of sodium alendronate presenting gastro-resistance and sustained release suitable for its oral administration. |
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High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticleshydrophilic drugsodium alendronatemicroparticlesThe hydrophilic drug sodium alendronate was encapsulated in blended microparticles of Eudragit® S100 and Methocel® F4M or Methocel® K100LV. Both formulations prepared by spray-drying showed spherical collapsed shape and smooth surface, encapsulation efficiencies of 85 and 82% and mean diameters of 11.7 and 8.4 µm, respectively. At pH 1.2, in vitro dissolution studies showed good gastro-resistance for both formulations. At pH 6.8, the sodium alendronate release from the microparticles was delayed and was controlled by Fickian diffusion. In conclusion, the prepared microparticles showed high encapsulation efficiency of sodium alendronate presenting gastro-resistance and sustained release suitable for its oral administration.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500016Química Nova v.32 n.5 2009reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422009000500016info:eu-repo/semantics/openAccessCruz,LetíciaAssumpção,EveliseGuterres,Sílvia StanisçuaskiPohlmann,Adriana Raffineng2009-07-30T00:00:00Zoai:scielo:S0100-40422009000500016Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2009-07-30T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles |
title |
High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles |
spellingShingle |
High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles Cruz,Letícia hydrophilic drug sodium alendronate microparticles |
title_short |
High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles |
title_full |
High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles |
title_fullStr |
High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles |
title_full_unstemmed |
High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles |
title_sort |
High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles |
author |
Cruz,Letícia |
author_facet |
Cruz,Letícia Assumpção,Evelise Guterres,Sílvia Stanisçuaski Pohlmann,Adriana Raffin |
author_role |
author |
author2 |
Assumpção,Evelise Guterres,Sílvia Stanisçuaski Pohlmann,Adriana Raffin |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Cruz,Letícia Assumpção,Evelise Guterres,Sílvia Stanisçuaski Pohlmann,Adriana Raffin |
dc.subject.por.fl_str_mv |
hydrophilic drug sodium alendronate microparticles |
topic |
hydrophilic drug sodium alendronate microparticles |
description |
The hydrophilic drug sodium alendronate was encapsulated in blended microparticles of Eudragit® S100 and Methocel® F4M or Methocel® K100LV. Both formulations prepared by spray-drying showed spherical collapsed shape and smooth surface, encapsulation efficiencies of 85 and 82% and mean diameters of 11.7 and 8.4 µm, respectively. At pH 1.2, in vitro dissolution studies showed good gastro-resistance for both formulations. At pH 6.8, the sodium alendronate release from the microparticles was delayed and was controlled by Fickian diffusion. In conclusion, the prepared microparticles showed high encapsulation efficiency of sodium alendronate presenting gastro-resistance and sustained release suitable for its oral administration. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-40422009000500016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.32 n.5 2009 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318109144645632 |