Nanoemulsões como sistemas de liberação parenteral de fármacos

Detalhes bibliográficos
Autor(a) principal: Bruxel,Fernanda
Data de Publicação: 2012
Outros Autores: Laux,Manoela, Wild,Luisa Bartmann, Fraga,Michelle, Koester,Letícia S., Teixeira,Helder F.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000900023
Resumo: Lipid nanoemulsions have recently been proposed as parenteral delivery systems for poorly-soluble drugs. These systems consist of nanoscale oil/water dispersions stabilized by an appropriate surfactant system in which the drug is incorporated into the oil core and/or adsorbed at the interface. This article reviews technological aspects of such nanosystems, including their composition, preparation methods, and physicochemical properties. From this review, it was possible to identify five groups of nanoemulsions based on their composition. Biopharmaceutical aspects of formulations containing some commercially available drugs (diazepam, propofol, dexamethasone, etomidate, flurbiprofen and prostaglandin E1) were then discussed.
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spelling Nanoemulsões como sistemas de liberação parenteral de fármacosemulsionparenteraldrugLipid nanoemulsions have recently been proposed as parenteral delivery systems for poorly-soluble drugs. These systems consist of nanoscale oil/water dispersions stabilized by an appropriate surfactant system in which the drug is incorporated into the oil core and/or adsorbed at the interface. This article reviews technological aspects of such nanosystems, including their composition, preparation methods, and physicochemical properties. From this review, it was possible to identify five groups of nanoemulsions based on their composition. Biopharmaceutical aspects of formulations containing some commercially available drugs (diazepam, propofol, dexamethasone, etomidate, flurbiprofen and prostaglandin E1) were then discussed.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000900023Química Nova v.35 n.9 2012reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422012000900023info:eu-repo/semantics/openAccessBruxel,FernandaLaux,ManoelaWild,Luisa BartmannFraga,MichelleKoester,Letícia S.Teixeira,Helder F.por2012-10-05T00:00:00Zoai:scielo:S0100-40422012000900023Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2012-10-05T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Nanoemulsões como sistemas de liberação parenteral de fármacos
title Nanoemulsões como sistemas de liberação parenteral de fármacos
spellingShingle Nanoemulsões como sistemas de liberação parenteral de fármacos
Bruxel,Fernanda
emulsion
parenteral
drug
title_short Nanoemulsões como sistemas de liberação parenteral de fármacos
title_full Nanoemulsões como sistemas de liberação parenteral de fármacos
title_fullStr Nanoemulsões como sistemas de liberação parenteral de fármacos
title_full_unstemmed Nanoemulsões como sistemas de liberação parenteral de fármacos
title_sort Nanoemulsões como sistemas de liberação parenteral de fármacos
author Bruxel,Fernanda
author_facet Bruxel,Fernanda
Laux,Manoela
Wild,Luisa Bartmann
Fraga,Michelle
Koester,Letícia S.
Teixeira,Helder F.
author_role author
author2 Laux,Manoela
Wild,Luisa Bartmann
Fraga,Michelle
Koester,Letícia S.
Teixeira,Helder F.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bruxel,Fernanda
Laux,Manoela
Wild,Luisa Bartmann
Fraga,Michelle
Koester,Letícia S.
Teixeira,Helder F.
dc.subject.por.fl_str_mv emulsion
parenteral
drug
topic emulsion
parenteral
drug
description Lipid nanoemulsions have recently been proposed as parenteral delivery systems for poorly-soluble drugs. These systems consist of nanoscale oil/water dispersions stabilized by an appropriate surfactant system in which the drug is incorporated into the oil core and/or adsorbed at the interface. This article reviews technological aspects of such nanosystems, including their composition, preparation methods, and physicochemical properties. From this review, it was possible to identify five groups of nanoemulsions based on their composition. Biopharmaceutical aspects of formulations containing some commercially available drugs (diazepam, propofol, dexamethasone, etomidate, flurbiprofen and prostaglandin E1) were then discussed.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000900023
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000900023
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422012000900023
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.35 n.9 2012
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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