Nanoemulsões como sistemas de liberação parenteral de fármacos

Detalhes bibliográficos
Autor(a) principal: Bruxel, Fernanda
Data de Publicação: 2012
Outros Autores: Laux, Manoela, Wild, Luisa Bartmann, Fraga, Michelle, Koester, Leticia Scherer, Teixeira, Helder Ferreira
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/72932
Resumo: Lipid nanoemulsions have recently been proposed as parenteral delivery systems for poorly-soluble drugs. These systems consist of nanoscale oil/water dispersions stabilized by an appropriate surfactant system in which the drug is incorporated into the oil core and/or adsorbed at the interface. This article reviews technological aspects of such nanosystems, including their composition, preparation methods, and physicochemical properties. From this review, it was possible to identify five groups of nanoemulsions based on their composition. Biopharmaceutical aspects of formulations containing some commercially available drugs (diazepam, propofol, dexamethasone, etomidate, flurbiprofen and prostaglandin E1) were then discussed.
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spelling Bruxel, FernandaLaux, ManoelaWild, Luisa BartmannFraga, MichelleKoester, Leticia SchererTeixeira, Helder Ferreira2013-07-02T01:43:45Z20120100-4042http://hdl.handle.net/10183/72932000873372Lipid nanoemulsions have recently been proposed as parenteral delivery systems for poorly-soluble drugs. These systems consist of nanoscale oil/water dispersions stabilized by an appropriate surfactant system in which the drug is incorporated into the oil core and/or adsorbed at the interface. This article reviews technological aspects of such nanosystems, including their composition, preparation methods, and physicochemical properties. From this review, it was possible to identify five groups of nanoemulsions based on their composition. Biopharmaceutical aspects of formulations containing some commercially available drugs (diazepam, propofol, dexamethasone, etomidate, flurbiprofen and prostaglandin E1) were then discussed.application/pdfporQuímica nova. São Paulo: Sociedade Brasileira de Química, 1978-. Vol. 35, n. 9 (2012), p. 1827-1840NanoemulsõesLiberação controlada de fármacosMedicação parenteralEmulsionParenteralDrugNanoemulsões como sistemas de liberação parenteral de fármacosNanoemulsions as parenteral drug delivery systems info:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000873372.pdf000873372.pdfTexto completoapplication/pdf515716http://www.lume.ufrgs.br/bitstream/10183/72932/1/000873372.pdfc82bdbf46da489c0fd4db77d8f4774f3MD51TEXT000873372.pdf.txt000873372.pdf.txtExtracted Texttext/plain78757http://www.lume.ufrgs.br/bitstream/10183/72932/2/000873372.pdf.txtefbd61ce626abe19226085b6423a3dc2MD52THUMBNAIL000873372.pdf.jpg000873372.pdf.jpgGenerated Thumbnailimage/jpeg1895http://www.lume.ufrgs.br/bitstream/10183/72932/3/000873372.pdf.jpgd5ec311f35d45b0ce97e644468101240MD5310183/729322023-02-02 05:49:45.157322oai:www.lume.ufrgs.br:10183/72932Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-02-02T07:49:45Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Nanoemulsões como sistemas de liberação parenteral de fármacos
dc.title.alternative.en.fl_str_mv Nanoemulsions as parenteral drug delivery systems
title Nanoemulsões como sistemas de liberação parenteral de fármacos
spellingShingle Nanoemulsões como sistemas de liberação parenteral de fármacos
Bruxel, Fernanda
Nanoemulsões
Liberação controlada de fármacos
Medicação parenteral
Emulsion
Parenteral
Drug
title_short Nanoemulsões como sistemas de liberação parenteral de fármacos
title_full Nanoemulsões como sistemas de liberação parenteral de fármacos
title_fullStr Nanoemulsões como sistemas de liberação parenteral de fármacos
title_full_unstemmed Nanoemulsões como sistemas de liberação parenteral de fármacos
title_sort Nanoemulsões como sistemas de liberação parenteral de fármacos
author Bruxel, Fernanda
author_facet Bruxel, Fernanda
Laux, Manoela
Wild, Luisa Bartmann
Fraga, Michelle
Koester, Leticia Scherer
Teixeira, Helder Ferreira
author_role author
author2 Laux, Manoela
Wild, Luisa Bartmann
Fraga, Michelle
Koester, Leticia Scherer
Teixeira, Helder Ferreira
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bruxel, Fernanda
Laux, Manoela
Wild, Luisa Bartmann
Fraga, Michelle
Koester, Leticia Scherer
Teixeira, Helder Ferreira
dc.subject.por.fl_str_mv Nanoemulsões
Liberação controlada de fármacos
Medicação parenteral
topic Nanoemulsões
Liberação controlada de fármacos
Medicação parenteral
Emulsion
Parenteral
Drug
dc.subject.eng.fl_str_mv Emulsion
Parenteral
Drug
description Lipid nanoemulsions have recently been proposed as parenteral delivery systems for poorly-soluble drugs. These systems consist of nanoscale oil/water dispersions stabilized by an appropriate surfactant system in which the drug is incorporated into the oil core and/or adsorbed at the interface. This article reviews technological aspects of such nanosystems, including their composition, preparation methods, and physicochemical properties. From this review, it was possible to identify five groups of nanoemulsions based on their composition. Biopharmaceutical aspects of formulations containing some commercially available drugs (diazepam, propofol, dexamethasone, etomidate, flurbiprofen and prostaglandin E1) were then discussed.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2013-07-02T01:43:45Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/72932
dc.identifier.issn.pt_BR.fl_str_mv 0100-4042
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dc.language.iso.fl_str_mv por
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dc.relation.ispartof.pt_BR.fl_str_mv Química nova. São Paulo: Sociedade Brasileira de Química, 1978-. Vol. 35, n. 9 (2012), p. 1827-1840
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