Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos

Detalhes bibliográficos
Autor(a) principal: Muri,Estela Maris Freitas
Data de Publicação: 2014
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000200019
Resumo: Proteases catalyze the hydrolysis of peptide bonds of proteins and peptides to produce smaller peptides and free amino acids. These enzymes are involved in physiologic processes such as blood coagulation and cellular death, and are related to life cycle of several viruses, such as hepatitis C, dengue, and AIDS. These features make most of proteases very important therapeutic targets for new pharmaceutical compounds. The development of peptidemimetics with improved pharmacokinetic properties is driving extensive research in the field of viral protease inhibitors. The present paper aims to highlight the design and synthesis of peptidemimetics that are able to inhibit viral proteases related to hepatitis C, dengue, and AIDS.
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spelling Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticosviral proteasespeptidemimeticsinhibitorsProteases catalyze the hydrolysis of peptide bonds of proteins and peptides to produce smaller peptides and free amino acids. These enzymes are involved in physiologic processes such as blood coagulation and cellular death, and are related to life cycle of several viruses, such as hepatitis C, dengue, and AIDS. These features make most of proteases very important therapeutic targets for new pharmaceutical compounds. The development of peptidemimetics with improved pharmacokinetic properties is driving extensive research in the field of viral protease inhibitors. The present paper aims to highlight the design and synthesis of peptidemimetics that are able to inhibit viral proteases related to hepatitis C, dengue, and AIDS.Sociedade Brasileira de Química2014-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000200019Química Nova v.37 n.2 2014reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0100-4042.20140052info:eu-repo/semantics/openAccessMuri,Estela Maris Freitaspor2014-04-29T00:00:00Zoai:scielo:S0100-40422014000200019Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2014-04-29T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos
title Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos
spellingShingle Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos
Muri,Estela Maris Freitas
viral proteases
peptidemimetics
inhibitors
title_short Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos
title_full Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos
title_fullStr Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos
title_full_unstemmed Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos
title_sort Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos
author Muri,Estela Maris Freitas
author_facet Muri,Estela Maris Freitas
author_role author
dc.contributor.author.fl_str_mv Muri,Estela Maris Freitas
dc.subject.por.fl_str_mv viral proteases
peptidemimetics
inhibitors
topic viral proteases
peptidemimetics
inhibitors
description Proteases catalyze the hydrolysis of peptide bonds of proteins and peptides to produce smaller peptides and free amino acids. These enzymes are involved in physiologic processes such as blood coagulation and cellular death, and are related to life cycle of several viruses, such as hepatitis C, dengue, and AIDS. These features make most of proteases very important therapeutic targets for new pharmaceutical compounds. The development of peptidemimetics with improved pharmacokinetic properties is driving extensive research in the field of viral protease inhibitors. The present paper aims to highlight the design and synthesis of peptidemimetics that are able to inhibit viral proteases related to hepatitis C, dengue, and AIDS.
publishDate 2014
dc.date.none.fl_str_mv 2014-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000200019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000200019
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.5935/0100-4042.20140052
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.37 n.2 2014
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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