Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000200019 |
Resumo: | Proteases catalyze the hydrolysis of peptide bonds of proteins and peptides to produce smaller peptides and free amino acids. These enzymes are involved in physiologic processes such as blood coagulation and cellular death, and are related to life cycle of several viruses, such as hepatitis C, dengue, and AIDS. These features make most of proteases very important therapeutic targets for new pharmaceutical compounds. The development of peptidemimetics with improved pharmacokinetic properties is driving extensive research in the field of viral protease inhibitors. The present paper aims to highlight the design and synthesis of peptidemimetics that are able to inhibit viral proteases related to hepatitis C, dengue, and AIDS. |
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Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticosviral proteasespeptidemimeticsinhibitorsProteases catalyze the hydrolysis of peptide bonds of proteins and peptides to produce smaller peptides and free amino acids. These enzymes are involved in physiologic processes such as blood coagulation and cellular death, and are related to life cycle of several viruses, such as hepatitis C, dengue, and AIDS. These features make most of proteases very important therapeutic targets for new pharmaceutical compounds. The development of peptidemimetics with improved pharmacokinetic properties is driving extensive research in the field of viral protease inhibitors. The present paper aims to highlight the design and synthesis of peptidemimetics that are able to inhibit viral proteases related to hepatitis C, dengue, and AIDS.Sociedade Brasileira de Química2014-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000200019Química Nova v.37 n.2 2014reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0100-4042.20140052info:eu-repo/semantics/openAccessMuri,Estela Maris Freitaspor2014-04-29T00:00:00Zoai:scielo:S0100-40422014000200019Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2014-04-29T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos |
title |
Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos |
spellingShingle |
Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos Muri,Estela Maris Freitas viral proteases peptidemimetics inhibitors |
title_short |
Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos |
title_full |
Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos |
title_fullStr |
Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos |
title_full_unstemmed |
Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos |
title_sort |
Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos |
author |
Muri,Estela Maris Freitas |
author_facet |
Muri,Estela Maris Freitas |
author_role |
author |
dc.contributor.author.fl_str_mv |
Muri,Estela Maris Freitas |
dc.subject.por.fl_str_mv |
viral proteases peptidemimetics inhibitors |
topic |
viral proteases peptidemimetics inhibitors |
description |
Proteases catalyze the hydrolysis of peptide bonds of proteins and peptides to produce smaller peptides and free amino acids. These enzymes are involved in physiologic processes such as blood coagulation and cellular death, and are related to life cycle of several viruses, such as hepatitis C, dengue, and AIDS. These features make most of proteases very important therapeutic targets for new pharmaceutical compounds. The development of peptidemimetics with improved pharmacokinetic properties is driving extensive research in the field of viral protease inhibitors. The present paper aims to highlight the design and synthesis of peptidemimetics that are able to inhibit viral proteases related to hepatitis C, dengue, and AIDS. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000200019 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000200019 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
10.5935/0100-4042.20140052 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.37 n.2 2014 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318115532570624 |