Effect of metal ions on the in vitro availability of enoxacin, its in vivo implications, kinetic and antibacterial studies
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000200003 |
Resumo: | The present paper describes the effect of metals ions on the in vitro availability of enoxacin (a second generation quinolone antibiotic) owing to drug-metal interaction. These interaction studies were performed at 37 °C in different pH environments simulating human body compartments and were studied by UV spectroscopic technique. In order to determine the probability of these reactions different kinetic parameters (dissolution constants (K) and free energy change (ΔG)) for these reactions were also calculated. It is proposed that the structure of enoxacin contains various electron donating sites which facilitate its binding with metallic cations forming chelates. Hence taking food products, nutritional supplements or multivitamins containing multivalent cations at the same time as enoxacin, could reduce the absorption of the drug into the circulation and thus would decrease the effectiveness of the drug. In addition, the MIC of enoxacin for various microorganisms before and after interaction with metal ions was calculated which in most cases was increased which possibly could impair the clinical efficacy of the drug. |
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Effect of metal ions on the in vitro availability of enoxacin, its in vivo implications, kinetic and antibacterial studiesmetal interactionenoxacinUV spectroscopyThe present paper describes the effect of metals ions on the in vitro availability of enoxacin (a second generation quinolone antibiotic) owing to drug-metal interaction. These interaction studies were performed at 37 °C in different pH environments simulating human body compartments and were studied by UV spectroscopic technique. In order to determine the probability of these reactions different kinetic parameters (dissolution constants (K) and free energy change (ΔG)) for these reactions were also calculated. It is proposed that the structure of enoxacin contains various electron donating sites which facilitate its binding with metallic cations forming chelates. Hence taking food products, nutritional supplements or multivitamins containing multivalent cations at the same time as enoxacin, could reduce the absorption of the drug into the circulation and thus would decrease the effectiveness of the drug. In addition, the MIC of enoxacin for various microorganisms before and after interaction with metal ions was calculated which in most cases was increased which possibly could impair the clinical efficacy of the drug.Sociedade Brasileira de Química2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000200003Química Nova v.34 n.2 2011reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422011000200003info:eu-repo/semantics/openAccessSultana,NajmaHumza,ErumArayne,Muhammad SaeedHaroon,Uroojeng2011-03-14T00:00:00Zoai:scielo:S0100-40422011000200003Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-03-14T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Effect of metal ions on the in vitro availability of enoxacin, its in vivo implications, kinetic and antibacterial studies |
title |
Effect of metal ions on the in vitro availability of enoxacin, its in vivo implications, kinetic and antibacterial studies |
spellingShingle |
Effect of metal ions on the in vitro availability of enoxacin, its in vivo implications, kinetic and antibacterial studies Sultana,Najma metal interaction enoxacin UV spectroscopy |
title_short |
Effect of metal ions on the in vitro availability of enoxacin, its in vivo implications, kinetic and antibacterial studies |
title_full |
Effect of metal ions on the in vitro availability of enoxacin, its in vivo implications, kinetic and antibacterial studies |
title_fullStr |
Effect of metal ions on the in vitro availability of enoxacin, its in vivo implications, kinetic and antibacterial studies |
title_full_unstemmed |
Effect of metal ions on the in vitro availability of enoxacin, its in vivo implications, kinetic and antibacterial studies |
title_sort |
Effect of metal ions on the in vitro availability of enoxacin, its in vivo implications, kinetic and antibacterial studies |
author |
Sultana,Najma |
author_facet |
Sultana,Najma Humza,Erum Arayne,Muhammad Saeed Haroon,Urooj |
author_role |
author |
author2 |
Humza,Erum Arayne,Muhammad Saeed Haroon,Urooj |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Sultana,Najma Humza,Erum Arayne,Muhammad Saeed Haroon,Urooj |
dc.subject.por.fl_str_mv |
metal interaction enoxacin UV spectroscopy |
topic |
metal interaction enoxacin UV spectroscopy |
description |
The present paper describes the effect of metals ions on the in vitro availability of enoxacin (a second generation quinolone antibiotic) owing to drug-metal interaction. These interaction studies were performed at 37 °C in different pH environments simulating human body compartments and were studied by UV spectroscopic technique. In order to determine the probability of these reactions different kinetic parameters (dissolution constants (K) and free energy change (ΔG)) for these reactions were also calculated. It is proposed that the structure of enoxacin contains various electron donating sites which facilitate its binding with metallic cations forming chelates. Hence taking food products, nutritional supplements or multivitamins containing multivalent cations at the same time as enoxacin, could reduce the absorption of the drug into the circulation and thus would decrease the effectiveness of the drug. In addition, the MIC of enoxacin for various microorganisms before and after interaction with metal ions was calculated which in most cases was increased which possibly could impair the clinical efficacy of the drug. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000200003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000200003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-40422011000200003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.34 n.2 2011 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318111819563008 |