Cytotoxicity and Antibacterial Activity of Silver Complexes Bearing Semicarbazones and Triphenylphosphine
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/slct.202004093 http://hdl.handle.net/11449/206948 |
Resumo: | The present work aimed to evaluate the biological activities of the silver (I) complexes, with the formulae [Ag(L)(PPh3)2]+ and [Ag(L)2]+ (L=(E)-2-((E)-3-phenylallylidene) hydrazine-1-carboxamide – CSC and (2E)-2-[(3E)-4-phenylbut-3-en-2-ylidene]-hydrazinecarboxamide – BSC). Four new silver(I) compounds were synthesized and characterized by NMR 1H, 13C-{1H}, 31P, IR, and UV-Vis spectroscopies, molar conductivity, and elemental analysis (CNH). High cytotoxicity was found for all complexes being more active than cisplatin in the tested cell lines. The antibacterial assay demonstrated that the compounds without phosphine groups presented high levels of inhibition (80 %) at 70.4 uM against the Gram-positive and Gram-negative bacteria strains. The DNA interactions were investigated by UV-Vis DNA titration, electrophoresis, and circular dichroism experiments. Data showed that the compounds did not interact with DNA in the tested conditions. However, the compounds have provided important information about the structural features that are needed in order to design new silver (I) complexes with biological activities. |
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Cytotoxicity and Antibacterial Activity of Silver Complexes Bearing Semicarbazones and TriphenylphosphineAntibacterialAntiproliferationDNA interactionNMR spectroscopySilver (I)The present work aimed to evaluate the biological activities of the silver (I) complexes, with the formulae [Ag(L)(PPh3)2]+ and [Ag(L)2]+ (L=(E)-2-((E)-3-phenylallylidene) hydrazine-1-carboxamide – CSC and (2E)-2-[(3E)-4-phenylbut-3-en-2-ylidene]-hydrazinecarboxamide – BSC). Four new silver(I) compounds were synthesized and characterized by NMR 1H, 13C-{1H}, 31P, IR, and UV-Vis spectroscopies, molar conductivity, and elemental analysis (CNH). High cytotoxicity was found for all complexes being more active than cisplatin in the tested cell lines. The antibacterial assay demonstrated that the compounds without phosphine groups presented high levels of inhibition (80 %) at 70.4 uM against the Gram-positive and Gram-negative bacteria strains. The DNA interactions were investigated by UV-Vis DNA titration, electrophoresis, and circular dichroism experiments. Data showed that the compounds did not interact with DNA in the tested conditions. However, the compounds have provided important information about the structural features that are needed in order to design new silver (I) complexes with biological activities.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Chemistry Department Federal University of São Carlos Rod. Washington Luis Km 235Department of Analytical Chemistry Physicochemical and Inorganic Chemistry. UNESP – Univ Estadual Paulista Institute of Chemistry Av. Prof. Francisco Degni 55Department of Biochemistry and Organic Chemistry. UNESP – Univ Estadual Paulista Institute of Chemistry Av. Prof. Francisco Degni 55Department of Analytical Chemistry Physicochemical and Inorganic Chemistry. UNESP – Univ Estadual Paulista Institute of Chemistry Av. Prof. Francisco Degni 55Department of Biochemistry and Organic Chemistry. UNESP – Univ Estadual Paulista Institute of Chemistry Av. Prof. Francisco Degni 55FAPESP: 2018/03018-1FAPESP: 2019/17584-1FAPESP: FAPESP 2019/11242-1Km 235Universidade Estadual Paulista (Unesp)Almeida, Vitor Y. G.Rocha, Josias S.Felix, Débora P.Oliveira, Gabriela P.Lima, Mauro A.Farias, Renan L. [UNESP]Zanetti, Renan D. [UNESP]Netto, Adelino V. G. [UNESP]Zambom, Carolina R. [UNESP]Garrido, Saulo S. [UNESP]Rocha, Fillipe V.2021-06-25T10:46:33Z2021-06-25T10:46:33Z2020-12-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14559-14563http://dx.doi.org/10.1002/slct.202004093ChemistrySelect, v. 5, n. 46, p. 14559-14563, 2020.2365-6549http://hdl.handle.net/11449/20694810.1002/slct.2020040932-s2.0-85097440819Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengChemistrySelectinfo:eu-repo/semantics/openAccess2021-10-23T15:48:27Zoai:repositorio.unesp.br:11449/206948Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:46:09.883155Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cytotoxicity and Antibacterial Activity of Silver Complexes Bearing Semicarbazones and Triphenylphosphine |
title |
Cytotoxicity and Antibacterial Activity of Silver Complexes Bearing Semicarbazones and Triphenylphosphine |
spellingShingle |
Cytotoxicity and Antibacterial Activity of Silver Complexes Bearing Semicarbazones and Triphenylphosphine Almeida, Vitor Y. G. Antibacterial Antiproliferation DNA interaction NMR spectroscopy Silver (I) |
title_short |
Cytotoxicity and Antibacterial Activity of Silver Complexes Bearing Semicarbazones and Triphenylphosphine |
title_full |
Cytotoxicity and Antibacterial Activity of Silver Complexes Bearing Semicarbazones and Triphenylphosphine |
title_fullStr |
Cytotoxicity and Antibacterial Activity of Silver Complexes Bearing Semicarbazones and Triphenylphosphine |
title_full_unstemmed |
Cytotoxicity and Antibacterial Activity of Silver Complexes Bearing Semicarbazones and Triphenylphosphine |
title_sort |
Cytotoxicity and Antibacterial Activity of Silver Complexes Bearing Semicarbazones and Triphenylphosphine |
author |
Almeida, Vitor Y. G. |
author_facet |
Almeida, Vitor Y. G. Rocha, Josias S. Felix, Débora P. Oliveira, Gabriela P. Lima, Mauro A. Farias, Renan L. [UNESP] Zanetti, Renan D. [UNESP] Netto, Adelino V. G. [UNESP] Zambom, Carolina R. [UNESP] Garrido, Saulo S. [UNESP] Rocha, Fillipe V. |
author_role |
author |
author2 |
Rocha, Josias S. Felix, Débora P. Oliveira, Gabriela P. Lima, Mauro A. Farias, Renan L. [UNESP] Zanetti, Renan D. [UNESP] Netto, Adelino V. G. [UNESP] Zambom, Carolina R. [UNESP] Garrido, Saulo S. [UNESP] Rocha, Fillipe V. |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Km 235 Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Almeida, Vitor Y. G. Rocha, Josias S. Felix, Débora P. Oliveira, Gabriela P. Lima, Mauro A. Farias, Renan L. [UNESP] Zanetti, Renan D. [UNESP] Netto, Adelino V. G. [UNESP] Zambom, Carolina R. [UNESP] Garrido, Saulo S. [UNESP] Rocha, Fillipe V. |
dc.subject.por.fl_str_mv |
Antibacterial Antiproliferation DNA interaction NMR spectroscopy Silver (I) |
topic |
Antibacterial Antiproliferation DNA interaction NMR spectroscopy Silver (I) |
description |
The present work aimed to evaluate the biological activities of the silver (I) complexes, with the formulae [Ag(L)(PPh3)2]+ and [Ag(L)2]+ (L=(E)-2-((E)-3-phenylallylidene) hydrazine-1-carboxamide – CSC and (2E)-2-[(3E)-4-phenylbut-3-en-2-ylidene]-hydrazinecarboxamide – BSC). Four new silver(I) compounds were synthesized and characterized by NMR 1H, 13C-{1H}, 31P, IR, and UV-Vis spectroscopies, molar conductivity, and elemental analysis (CNH). High cytotoxicity was found for all complexes being more active than cisplatin in the tested cell lines. The antibacterial assay demonstrated that the compounds without phosphine groups presented high levels of inhibition (80 %) at 70.4 uM against the Gram-positive and Gram-negative bacteria strains. The DNA interactions were investigated by UV-Vis DNA titration, electrophoresis, and circular dichroism experiments. Data showed that the compounds did not interact with DNA in the tested conditions. However, the compounds have provided important information about the structural features that are needed in order to design new silver (I) complexes with biological activities. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-11 2021-06-25T10:46:33Z 2021-06-25T10:46:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/slct.202004093 ChemistrySelect, v. 5, n. 46, p. 14559-14563, 2020. 2365-6549 http://hdl.handle.net/11449/206948 10.1002/slct.202004093 2-s2.0-85097440819 |
url |
http://dx.doi.org/10.1002/slct.202004093 http://hdl.handle.net/11449/206948 |
identifier_str_mv |
ChemistrySelect, v. 5, n. 46, p. 14559-14563, 2020. 2365-6549 10.1002/slct.202004093 2-s2.0-85097440819 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
ChemistrySelect |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
14559-14563 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128414480072704 |