Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate

Detalhes bibliográficos
Autor(a) principal: Silva,Breno de Carvalho e
Data de Publicação: 2005
Outros Autores: Campos,Lígia Maria Moreira de, Pianetti,Gerson Antônio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000100011
Resumo: A simple and rapid precipitation titration method was developed and validated to determine sulfate ion content in indinavir sulfate raw material. 0.1 mol L-1 lead nitrate volumetric solution was used as titrant employing potentiometric endpoint determination using a lead-specific electrode. The United States Pharmacopoeia Forum indicates a potentiometric method for sulfate ion quantitation using 0.1 mol L-1 lead perchlorate as titrant. Both methods were validated concerning linearity, precision and accuracy, yielding good results. The sulfate ion content found by the two validated methods was compared by the statistical t-student test, indicating that there was no statistically significant difference between the methods.
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spelling Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfateindinavir sulfatetitrationsulfate ion contentA simple and rapid precipitation titration method was developed and validated to determine sulfate ion content in indinavir sulfate raw material. 0.1 mol L-1 lead nitrate volumetric solution was used as titrant employing potentiometric endpoint determination using a lead-specific electrode. The United States Pharmacopoeia Forum indicates a potentiometric method for sulfate ion quantitation using 0.1 mol L-1 lead perchlorate as titrant. Both methods were validated concerning linearity, precision and accuracy, yielding good results. The sulfate ion content found by the two validated methods was compared by the statistical t-student test, indicating that there was no statistically significant difference between the methods.Sociedade Brasileira de Química2005-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000100011Química Nova v.28 n.1 2005reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422005000100011info:eu-repo/semantics/openAccessSilva,Breno de Carvalho eCampos,Lígia Maria Moreira dePianetti,Gerson Antônioeng2005-02-23T00:00:00Zoai:scielo:S0100-40422005000100011Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2005-02-23T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate
title Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate
spellingShingle Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate
Silva,Breno de Carvalho e
indinavir sulfate
titration
sulfate ion content
title_short Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate
title_full Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate
title_fullStr Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate
title_full_unstemmed Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate
title_sort Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate
author Silva,Breno de Carvalho e
author_facet Silva,Breno de Carvalho e
Campos,Lígia Maria Moreira de
Pianetti,Gerson Antônio
author_role author
author2 Campos,Lígia Maria Moreira de
Pianetti,Gerson Antônio
author2_role author
author
dc.contributor.author.fl_str_mv Silva,Breno de Carvalho e
Campos,Lígia Maria Moreira de
Pianetti,Gerson Antônio
dc.subject.por.fl_str_mv indinavir sulfate
titration
sulfate ion content
topic indinavir sulfate
titration
sulfate ion content
description A simple and rapid precipitation titration method was developed and validated to determine sulfate ion content in indinavir sulfate raw material. 0.1 mol L-1 lead nitrate volumetric solution was used as titrant employing potentiometric endpoint determination using a lead-specific electrode. The United States Pharmacopoeia Forum indicates a potentiometric method for sulfate ion quantitation using 0.1 mol L-1 lead perchlorate as titrant. Both methods were validated concerning linearity, precision and accuracy, yielding good results. The sulfate ion content found by the two validated methods was compared by the statistical t-student test, indicating that there was no statistically significant difference between the methods.
publishDate 2005
dc.date.none.fl_str_mv 2005-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000100011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000100011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422005000100011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.28 n.1 2005
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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