Metilglioxal: uma toxina endógena?

Detalhes bibliográficos
Autor(a) principal: Sartori,Adriano
Data de Publicação: 2010
Outros Autores: Bechara,Etelvino José Henriques
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010001000032
Resumo: Methylglyoxal is a very reactive α-oxoaldehyde putatively produced by glycolysis, cytochrome P450-catalyzed acetone oxidation and aminoacetone oxidation. Methylglyoxal has been pointed as a substrate for the glyoxalase system ultimately energy-yielding pyruvate, but methylglyoxal is also a toxicant involved in protein aggregation and DNA modification. Controversial hypothesis on methylglyoxal as an anticancer agent, an energy-yielding glycolysis intermediates, and as a regulator of cell division have also been proposed. Methylglyoxal research focuses now on unveiling its biological properties and on the discovery of drugs capable to inhibit its toxic effects, principally in diabetes.
id SBQ-3_e0b4d3f2467e796ce05d52cfc1e4898b
oai_identifier_str oai:scielo:S0100-40422010001000032
network_acronym_str SBQ-3
network_name_str Química Nova (Online)
repository_id_str
spelling Metilglioxal: uma toxina endógena?KeywordsmethylglyoxalglyoxalasesdiabetesMethylglyoxal is a very reactive α-oxoaldehyde putatively produced by glycolysis, cytochrome P450-catalyzed acetone oxidation and aminoacetone oxidation. Methylglyoxal has been pointed as a substrate for the glyoxalase system ultimately energy-yielding pyruvate, but methylglyoxal is also a toxicant involved in protein aggregation and DNA modification. Controversial hypothesis on methylglyoxal as an anticancer agent, an energy-yielding glycolysis intermediates, and as a regulator of cell division have also been proposed. Methylglyoxal research focuses now on unveiling its biological properties and on the discovery of drugs capable to inhibit its toxic effects, principally in diabetes.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010001000032Química Nova v.33 n.10 2010reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422010001000032info:eu-repo/semantics/openAccessSartori,AdrianoBechara,Etelvino José Henriquespor2010-12-16T00:00:00Zoai:scielo:S0100-40422010001000032Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2010-12-16T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Metilglioxal: uma toxina endógena?
title Metilglioxal: uma toxina endógena?
spellingShingle Metilglioxal: uma toxina endógena?
Sartori,Adriano
Keywords
methylglyoxal
glyoxalases
diabetes
title_short Metilglioxal: uma toxina endógena?
title_full Metilglioxal: uma toxina endógena?
title_fullStr Metilglioxal: uma toxina endógena?
title_full_unstemmed Metilglioxal: uma toxina endógena?
title_sort Metilglioxal: uma toxina endógena?
author Sartori,Adriano
author_facet Sartori,Adriano
Bechara,Etelvino José Henriques
author_role author
author2 Bechara,Etelvino José Henriques
author2_role author
dc.contributor.author.fl_str_mv Sartori,Adriano
Bechara,Etelvino José Henriques
dc.subject.por.fl_str_mv Keywords
methylglyoxal
glyoxalases
diabetes
topic Keywords
methylglyoxal
glyoxalases
diabetes
description Methylglyoxal is a very reactive α-oxoaldehyde putatively produced by glycolysis, cytochrome P450-catalyzed acetone oxidation and aminoacetone oxidation. Methylglyoxal has been pointed as a substrate for the glyoxalase system ultimately energy-yielding pyruvate, but methylglyoxal is also a toxicant involved in protein aggregation and DNA modification. Controversial hypothesis on methylglyoxal as an anticancer agent, an energy-yielding glycolysis intermediates, and as a regulator of cell division have also been proposed. Methylglyoxal research focuses now on unveiling its biological properties and on the discovery of drugs capable to inhibit its toxic effects, principally in diabetes.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010001000032
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010001000032
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422010001000032
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.33 n.10 2010
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
_version_ 1750318111503941632

Registros relacionados