Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms

Detalhes bibliográficos
Autor(a) principal: Ourique,Aline Ferreira
Data de Publicação: 2012
Outros Autores: Contri,Renata Vidor, Guterres,Silvia Stanisçuaski, Beck,Ruy Carlos Ruver, Pohlmann,Adriana Raffin, Melero,Ana, Schaefer,Ulrich F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400030
Resumo: A reliable method using LC-UV to assay mometasone furoate (MF) in creams or nasal sprays using the same chromatographic conditions was set up. Methanol:water 80:20 (v/v) (1.0 mL min-1) was used as mobile phase. MF was detected at 248 nm and analyzed in a concentration range from 1.0 to 20.0 µg mL-1. The method provided acceptable theoretical plates, peak simmetry, peak tailing factor and peak resolution a short run (5 min). The method showed specificity, good linearity (r = 0.9999) and the quantification limit was 0.379 µg mL-1. Furthermore, the method was precise (RSD < 2.0%), accurate (recovery &gt; 97%) and robust.
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spelling Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage formspharmaceuticalsliquid chromatographymometasoneA reliable method using LC-UV to assay mometasone furoate (MF) in creams or nasal sprays using the same chromatographic conditions was set up. Methanol:water 80:20 (v/v) (1.0 mL min-1) was used as mobile phase. MF was detected at 248 nm and analyzed in a concentration range from 1.0 to 20.0 µg mL-1. The method provided acceptable theoretical plates, peak simmetry, peak tailing factor and peak resolution a short run (5 min). The method showed specificity, good linearity (r = 0.9999) and the quantification limit was 0.379 µg mL-1. Furthermore, the method was precise (RSD < 2.0%), accurate (recovery &gt; 97%) and robust.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400030Química Nova v.35 n.4 2012reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422012000400030info:eu-repo/semantics/openAccessOurique,Aline FerreiraContri,Renata VidorGuterres,Silvia StanisçuaskiBeck,Ruy Carlos RuverPohlmann,Adriana RaffinMelero,AnaSchaefer,Ulrich F.eng2012-05-25T00:00:00Zoai:scielo:S0100-40422012000400030Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2012-05-25T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
title Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
spellingShingle Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
Ourique,Aline Ferreira
pharmaceuticals
liquid chromatography
mometasone
title_short Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
title_full Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
title_fullStr Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
title_full_unstemmed Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
title_sort Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
author Ourique,Aline Ferreira
author_facet Ourique,Aline Ferreira
Contri,Renata Vidor
Guterres,Silvia Stanisçuaski
Beck,Ruy Carlos Ruver
Pohlmann,Adriana Raffin
Melero,Ana
Schaefer,Ulrich F.
author_role author
author2 Contri,Renata Vidor
Guterres,Silvia Stanisçuaski
Beck,Ruy Carlos Ruver
Pohlmann,Adriana Raffin
Melero,Ana
Schaefer,Ulrich F.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ourique,Aline Ferreira
Contri,Renata Vidor
Guterres,Silvia Stanisçuaski
Beck,Ruy Carlos Ruver
Pohlmann,Adriana Raffin
Melero,Ana
Schaefer,Ulrich F.
dc.subject.por.fl_str_mv pharmaceuticals
liquid chromatography
mometasone
topic pharmaceuticals
liquid chromatography
mometasone
description A reliable method using LC-UV to assay mometasone furoate (MF) in creams or nasal sprays using the same chromatographic conditions was set up. Methanol:water 80:20 (v/v) (1.0 mL min-1) was used as mobile phase. MF was detected at 248 nm and analyzed in a concentration range from 1.0 to 20.0 µg mL-1. The method provided acceptable theoretical plates, peak simmetry, peak tailing factor and peak resolution a short run (5 min). The method showed specificity, good linearity (r = 0.9999) and the quantification limit was 0.379 µg mL-1. Furthermore, the method was precise (RSD < 2.0%), accurate (recovery &gt; 97%) and robust.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400030
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400030
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422012000400030
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.35 n.4 2012
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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